Involvement of the ADAM 12 in Thrombin-Induced Rats VSMCs Proliferation
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Аутори
Smiljanić, KatarinaDobutovic, B.
Obradović, Milan M.
Nikolić, Dragana
Marche, Pierre
Isenović, Esma R.
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Приказ свих података о документуАпстракт
Cardiovascular disease is the largest single cause of mortality and its major underlying pathology is atherosclerosis. The proliferation of vascular smooth muscle cells (VSMCs) is a key event in the pathogenesis of the various vascular diseases, including atherosclerosis and hypertension. Thrombin (Thr) is involved in the abnormal proliferation of VSMCs associated with atherosclerosis and hypertension. ADAMs (A Disintegrin And Metalloproteinase) are transmembrane metalloproteinases, belonging to the adamalysins group, that are distinct from matrix metalloproteinases (MMPs) in a way as they have an extracellular disintegrin domain and cytoplasmic domain that can associate with intracellular proteins. There is limited knowledge about the presence of ADAM metalloproteinase activity in Thr-induced VSMCs proliferation. Therefore, this review examines recent findings in signaling mechanisms employed by Thr in modulating the regulation of proliferation of VSMCs with particular emphasis on inv...olvement of ADAM 12 which has been identified as an important mediator of VSMCs hypertrophy and vascular diseases. These findings are critical for understanding the role of Thr in vascular biology and vascular diseases.
Кључне речи:
ADAM 12 / Atherosclerosis / Thrombin / Proliferation / VSMC / MMP / Cardiovascular diseases / Hypertension / Hypertrophy / Vascular diseasesИзвор:
Current Medicinal Chemistry, 2011, 18, 22, 3382-3386Финансирање / пројекти:
- Хормонска регулација експресије и активности азот оксид синтазе и натријум-калијумове пумпе у експерименталним моделима инсулинске резистенције, дијабетеса и кардиоваскуларних поремећаја (RS-MESTD-Basic Research (BR or ON)-173033)
- CNRS, University Pierre and Marie Curie, Pavle Savic [337-00-359/2005-01/16], Republic of France, Ministry of Foreign Affairs
DOI: 10.2174/092986711796504709
ISSN: 0929-8673
PubMed: 21728962
WoS: 000294405600013
Scopus: 2-s2.0-79961088085
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Институција/група
VinčaTY - JOUR AU - Smiljanić, Katarina AU - Dobutovic, B. AU - Obradović, Milan M. AU - Nikolić, Dragana AU - Marche, Pierre AU - Isenović, Esma R. PY - 2011 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4468 AB - Cardiovascular disease is the largest single cause of mortality and its major underlying pathology is atherosclerosis. The proliferation of vascular smooth muscle cells (VSMCs) is a key event in the pathogenesis of the various vascular diseases, including atherosclerosis and hypertension. Thrombin (Thr) is involved in the abnormal proliferation of VSMCs associated with atherosclerosis and hypertension. ADAMs (A Disintegrin And Metalloproteinase) are transmembrane metalloproteinases, belonging to the adamalysins group, that are distinct from matrix metalloproteinases (MMPs) in a way as they have an extracellular disintegrin domain and cytoplasmic domain that can associate with intracellular proteins. There is limited knowledge about the presence of ADAM metalloproteinase activity in Thr-induced VSMCs proliferation. Therefore, this review examines recent findings in signaling mechanisms employed by Thr in modulating the regulation of proliferation of VSMCs with particular emphasis on involvement of ADAM 12 which has been identified as an important mediator of VSMCs hypertrophy and vascular diseases. These findings are critical for understanding the role of Thr in vascular biology and vascular diseases. T2 - Current Medicinal Chemistry T1 - Involvement of the ADAM 12 in Thrombin-Induced Rats VSMCs Proliferation VL - 18 IS - 22 SP - 3382 EP - 3386 DO - 10.2174/092986711796504709 ER -
@article{ author = "Smiljanić, Katarina and Dobutovic, B. and Obradović, Milan M. and Nikolić, Dragana and Marche, Pierre and Isenović, Esma R.", year = "2011", abstract = "Cardiovascular disease is the largest single cause of mortality and its major underlying pathology is atherosclerosis. The proliferation of vascular smooth muscle cells (VSMCs) is a key event in the pathogenesis of the various vascular diseases, including atherosclerosis and hypertension. Thrombin (Thr) is involved in the abnormal proliferation of VSMCs associated with atherosclerosis and hypertension. ADAMs (A Disintegrin And Metalloproteinase) are transmembrane metalloproteinases, belonging to the adamalysins group, that are distinct from matrix metalloproteinases (MMPs) in a way as they have an extracellular disintegrin domain and cytoplasmic domain that can associate with intracellular proteins. There is limited knowledge about the presence of ADAM metalloproteinase activity in Thr-induced VSMCs proliferation. Therefore, this review examines recent findings in signaling mechanisms employed by Thr in modulating the regulation of proliferation of VSMCs with particular emphasis on involvement of ADAM 12 which has been identified as an important mediator of VSMCs hypertrophy and vascular diseases. These findings are critical for understanding the role of Thr in vascular biology and vascular diseases.", journal = "Current Medicinal Chemistry", title = "Involvement of the ADAM 12 in Thrombin-Induced Rats VSMCs Proliferation", volume = "18", number = "22", pages = "3382-3386", doi = "10.2174/092986711796504709" }
Smiljanić, K., Dobutovic, B., Obradović, M. M., Nikolić, D., Marche, P.,& Isenović, E. R.. (2011). Involvement of the ADAM 12 in Thrombin-Induced Rats VSMCs Proliferation. in Current Medicinal Chemistry, 18(22), 3382-3386. https://doi.org/10.2174/092986711796504709
Smiljanić K, Dobutovic B, Obradović MM, Nikolić D, Marche P, Isenović ER. Involvement of the ADAM 12 in Thrombin-Induced Rats VSMCs Proliferation. in Current Medicinal Chemistry. 2011;18(22):3382-3386. doi:10.2174/092986711796504709 .
Smiljanić, Katarina, Dobutovic, B., Obradović, Milan M., Nikolić, Dragana, Marche, Pierre, Isenović, Esma R., "Involvement of the ADAM 12 in Thrombin-Induced Rats VSMCs Proliferation" in Current Medicinal Chemistry, 18, no. 22 (2011):3382-3386, https://doi.org/10.2174/092986711796504709 . .