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Preparation, crystal structure and antibacterial activity of condensation products of usnic acid and acyl hydrazides
dc.creator | Sladić, Dušan | |
dc.creator | Beljanski, Vladimir | |
dc.creator | Prelesnik, Bogdan | |
dc.creator | Bogdanović, Goran | |
dc.creator | Ivanović, Ivana | |
dc.creator | Anđelković, Katarina | |
dc.date.issued | 1998 | |
dc.identifier.issn | 0352-5139 | |
dc.description.abstract | Three condensation products of usnic acid with the hydrazides of α-naphthoic, caprylic, and oxamic acids, respectively, have been prepared and characterized by spectrometric methods. A reassignment of the 13C-NMR spectral data of usnic acid has been done. The crystal structure of usnic acid 11-[(1-naphthoyl)hydrazone] ethanol solvate (1:1) has been determined. This substance crystallizes in the monoclinic crystal system, the space group P21, with the unit cell dimensiones a = 7.7365(7) Å, b = 19.632(2) Å, c = 9.4150(15) Å, β = 108.830(11)° V = 1405.0(4) Å3, and Z = 2. At the end of the structure analysis R = 0.055, Rw = 0.052 and S = 0.89. The antibacterial activities of the compounds have been evaluated. The greatest activity against Staphylococcus aureus was found for usnic acid, somewhat lower for the derivatives with hydrazides of α-naphthoic and caprylic acid, and much lower for the derivative with semioxamazide. The activities of these compounds probably depend on their lipophilicity. | en |
dc.rights | restrictedAccess | |
dc.source | Journal of the Serbian Chemical Society | |
dc.subject | Usnic acid derivatives | en |
dc.subject | NMR spectra | en |
dc.subject | Crystal structure | en |
dc.subject | Biological activity | en |
dc.subject | Acyl hydrazides | en |
dc.title | Preparation, crystal structure and antibacterial activity of condensation products of usnic acid and acyl hydrazides | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.volume | 63 | |
dc.citation.issue | 3 | |
dc.citation.spage | 171 | |
dc.citation.epage | 182 | |
dc.identifier.wos | 000072976900002 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-0032331613 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_vinar_43 |
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