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Catheter-Based Renal Sympathetic Denervation for Resistant Hypertension Durability of Blood Pressure Reduction Out to 24 Months
dc.creator | Sadowski, Jerzy | |
dc.creator | Bartus, Krzysztof | |
dc.creator | Kapelak, Boguslaw | |
dc.creator | Rocha-Singh, Krishna J. | |
dc.creator | Katholi, Richard E. | |
dc.creator | Witkowski, Adam | |
dc.creator | Kadziela, Jacek | |
dc.creator | Januszewicz, Andrzej | |
dc.creator | Prejbisz, Aleksander | |
dc.creator | Walton, Anthony S. | |
dc.creator | Sievert, Horst | |
dc.creator | Id, Dani | |
dc.creator | Wunderlich, Nina | |
dc.creator | Whitbourn, Robert | |
dc.creator | Rump, Lars Christian | |
dc.creator | Vonend, Oliver | |
dc.creator | Saleh, Andreas | |
dc.creator | Thambar, Suku | |
dc.creator | Nanra, Ranjit | |
dc.creator | Zeller, Thomas | |
dc.creator | Erglis, Andrejs | |
dc.creator | Sagic, Dragan | |
dc.creator | Bošković, Srdjan | |
dc.creator | Brachmann, Johannes | |
dc.creator | Schmidt, Martin | |
dc.creator | Wenzel, Ulrich O. | |
dc.creator | Bart, Bradley A. | |
dc.creator | Schmieder, Roland E. | |
dc.creator | Scheinert, Dierk | |
dc.creator | Boergel, Jan | |
dc.creator | Straley, Craig | |
dc.creator | Symplicity HTN-1 Investigators | |
dc.date.accessioned | 2018-03-01T21:41:21Z | |
dc.date.available | 2018-03-01T21:41:21Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 0194-911X | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/4283 | |
dc.description.abstract | Renal sympathetic hyperactivity is seminal in the maintenance and progression of hypertension. Catheter-based renal sympathetic denervation has been shown to significantly reduce blood pressure (BP) in patients with hypertension. Durability of effect beyond 1 year using this novel technique has never been reported. A cohort of 45 patients with resistant hypertension (systolic BP GT = 160 mm Hg on GT = 3 antihypertension drugs, including a diuretic) has been originally published. Herein, we report longer-term follow-up data on these and a larger group of similar patients subsequently treated with catheter-based renal denervation in a nonrandomized manner. We treated 153 patients with catheter-based renal sympathetic denervation at 19 centers in Australia, Europe, and the United States. Mean age was 57 +/- 11 years, 39% were women, 31% were diabetic, and 22% had coronary artery disease. Baseline values included mean office BP of 176/98 +/- 17/15 mm Hg, mean of 5 antihypertension medications, and an estimated glomerular filtration rate of 83 +/- 20 mL/min per 1.73 m(2). The median time from first to last radiofrequency energy ablation was 38 minutes. The procedure was without complication in 97% of patients (149 of 153). The 4 acute procedural complications included 3 groin pseudoaneurysms and 1 renal artery dissection, all managed without further sequelae. Postprocedure office BPs were reduced by 20/10, 24/11, 25/11, 23/11, 26/14, and 32/14 mm Hg at 1, 3, 6, 12, 18, and 24 months, respectively. In conclusion, in patients with resistant hypertension, catheter-based renal sympathetic denervation results in a substantial reduction in BP sustained out to GT = 2 years of follow-up, without significant adverse events. (Hypertension. 2011;57:911-917.) | en |
dc.relation | Ardian, Inc. | |
dc.rights | openAccess | en |
dc.source | Hypertension | en |
dc.subject | hypertension | en |
dc.subject | blood pressure | en |
dc.subject | renal sympathetic denervation | en |
dc.title | Catheter-Based Renal Sympathetic Denervation for Resistant Hypertension Durability of Blood Pressure Reduction Out to 24 Months | en |
dc.type | article | en |
dcterms.abstract | Садоwски, Јерзy; Бартус, Крзyсзтоф; Капелак, Богуслаw; Роцха-Сингх, Крисхна Ј.; Катхоли, Рицхард Е.; Wиткоwски, Aдам; Кадзиела, Јацек; Јанусзеwицз, Aндрзеј; Прејбисз, Aлександер; Wалтон, Aнтхонy С.; Сиеверт, Хорст; Ид, Дани; Wундерлицх, Нина; Wхитбоурн, Роберт; Румп, Ларс Цхристиан; Воненд, Оливер; Салех, Aндреас; Тхамбар, Суку; Нанра, Рањит; Зеллер, Тхомас; Ерглис, Aндрејс; Сагиц, Драган; Босковиц, Срдјан; Брацхманн, Јоханнес; Сцхмидт, Мартин; Wензел, Улрицх О.; Барт, Брадлеy A.; Сцхмиедер, Роланд Е.; Сцхеинерт, Диерк; Боергел, Јан; Стралеy, Цраиг; Сyмплицитy ХТН-1 Инвестигаторс; | |
dc.citation.volume | 57 | |
dc.citation.issue | 5 | |
dc.citation.spage | 911 | |
dc.citation.epage | 917 | |
dc.identifier.wos | 000289730200017 | |
dc.identifier.doi | 10.1161/HYPERTENSIONAHA.110.163014 | |
dc.citation.rank | M21a | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-79955477242 | |
dc.identifier.fulltext | https://vinar.vin.bg.ac.rs//bitstream/id/12740/4279.pdf |