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Application of the EIIP/ISM bioinformatics concept in development of new drugs
(Current Medicinal Chemistry, 2007)
The development of a new therapeutic drug is a complex, lengthy and expensive process. On average, only one out of 10,000 - 30,000 originally synthesized compounds will clear all the hurdles on the way to becoming a ...
Involvement of the ADAM 12 in Thrombin-Induced Rats VSMCs Proliferation
(Current Medicinal Chemistry, 2011)
Cardiovascular disease is the largest single cause of mortality and its major underlying pathology is atherosclerosis. The proliferation of vascular smooth muscle cells (VSMCs) is a key event in the pathogenesis of the ...