Plasma Levels of Matrix Metalloproteinase-8 in Patients With Carotid Atherosclerosis
Authorized Users Only
2010
Authors
Đurić, TamaraŽivković, Maja
Stanković, Aleksandra
Kolaković, Ana
Jekić, Đole
Selaković, Vesna
Alavantić, Dragan
Article (Published version)
Metadata
Show full item recordAbstract
Matrix metalloproteinases (MMPs) are involved in the remodeling of the extracellular matrix (ECM) in the arterial wall during atherogenesis. Collagens are the most abundant proteins in the ECM. MMP-8 is expressed by cells associated with the development of the atherosclerotic plaque. It cleaves collagen type I three times more potently than two other interstitial collagenases MMP-1 and MMP-13. The aim of this study was to investigate whether plasma MMP-8 values are associated with occurrence of carotid plaque (CP) and possible correlations with clinical and biochemical parameters in carotid atherosclerosis (CA) patients. Total plasma MMP-8 levels were quantified by ELISA in 63 patients with ultrasonographic evidence of CP presence and 12 controls. Plasma MMP-8 values were significantly higher in patients with CA compared with controls (median 23.36 ng/ml vs. 13.02 ng/ml, P LT 0.001) but they did not differ significantly according to gender, smoking and hypertensive status, associated d...iseases, and use of statins. Statistically significant positive correlations were observed between MMP-8 plasma values and C reactive protein (r=0.41, P=0.001), urea (r=0.50, P LT 0.001), aspartate transaminase (r=0.48, P=0.001), and creatinine levels (r=0.38, P=0.006). These results suggest association of MMP-8 plasma levels with occurrence of CP and correlation with certain biochemical markers. J. Clin. Lab. Anal. 24:246-251, 2010. (C) 2010 Wiley-Liss, Inc.
Keywords:
atherosclerosis / carotid plaque / collagenase / correlation / MMP-8Source:
Journal of Clinical Laboratory Analysis, 2010, 24, 4, 246-251Funding / projects:
- Genetska epidemiologija i farmakogenomika vaskularnih oboljenja (RS-MESTD-MPN2006-2010-145023)
DOI: 10.1002/jcla.20393
ISSN: 0887-8013
PubMed: 20626027
WoS: 000283412000006
Scopus: 2-s2.0-77955650034
Collections
Institution/Community
VinčaTY - JOUR AU - Đurić, Tamara AU - Živković, Maja AU - Stanković, Aleksandra AU - Kolaković, Ana AU - Jekić, Đole AU - Selaković, Vesna AU - Alavantić, Dragan PY - 2010 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4129 AB - Matrix metalloproteinases (MMPs) are involved in the remodeling of the extracellular matrix (ECM) in the arterial wall during atherogenesis. Collagens are the most abundant proteins in the ECM. MMP-8 is expressed by cells associated with the development of the atherosclerotic plaque. It cleaves collagen type I three times more potently than two other interstitial collagenases MMP-1 and MMP-13. The aim of this study was to investigate whether plasma MMP-8 values are associated with occurrence of carotid plaque (CP) and possible correlations with clinical and biochemical parameters in carotid atherosclerosis (CA) patients. Total plasma MMP-8 levels were quantified by ELISA in 63 patients with ultrasonographic evidence of CP presence and 12 controls. Plasma MMP-8 values were significantly higher in patients with CA compared with controls (median 23.36 ng/ml vs. 13.02 ng/ml, P LT 0.001) but they did not differ significantly according to gender, smoking and hypertensive status, associated diseases, and use of statins. Statistically significant positive correlations were observed between MMP-8 plasma values and C reactive protein (r=0.41, P=0.001), urea (r=0.50, P LT 0.001), aspartate transaminase (r=0.48, P=0.001), and creatinine levels (r=0.38, P=0.006). These results suggest association of MMP-8 plasma levels with occurrence of CP and correlation with certain biochemical markers. J. Clin. Lab. Anal. 24:246-251, 2010. (C) 2010 Wiley-Liss, Inc. T2 - Journal of Clinical Laboratory Analysis T1 - Plasma Levels of Matrix Metalloproteinase-8 in Patients With Carotid Atherosclerosis VL - 24 IS - 4 SP - 246 EP - 251 DO - 10.1002/jcla.20393 ER -
@article{ author = "Đurić, Tamara and Živković, Maja and Stanković, Aleksandra and Kolaković, Ana and Jekić, Đole and Selaković, Vesna and Alavantić, Dragan", year = "2010", abstract = "Matrix metalloproteinases (MMPs) are involved in the remodeling of the extracellular matrix (ECM) in the arterial wall during atherogenesis. Collagens are the most abundant proteins in the ECM. MMP-8 is expressed by cells associated with the development of the atherosclerotic plaque. It cleaves collagen type I three times more potently than two other interstitial collagenases MMP-1 and MMP-13. The aim of this study was to investigate whether plasma MMP-8 values are associated with occurrence of carotid plaque (CP) and possible correlations with clinical and biochemical parameters in carotid atherosclerosis (CA) patients. Total plasma MMP-8 levels were quantified by ELISA in 63 patients with ultrasonographic evidence of CP presence and 12 controls. Plasma MMP-8 values were significantly higher in patients with CA compared with controls (median 23.36 ng/ml vs. 13.02 ng/ml, P LT 0.001) but they did not differ significantly according to gender, smoking and hypertensive status, associated diseases, and use of statins. Statistically significant positive correlations were observed between MMP-8 plasma values and C reactive protein (r=0.41, P=0.001), urea (r=0.50, P LT 0.001), aspartate transaminase (r=0.48, P=0.001), and creatinine levels (r=0.38, P=0.006). These results suggest association of MMP-8 plasma levels with occurrence of CP and correlation with certain biochemical markers. J. Clin. Lab. Anal. 24:246-251, 2010. (C) 2010 Wiley-Liss, Inc.", journal = "Journal of Clinical Laboratory Analysis", title = "Plasma Levels of Matrix Metalloproteinase-8 in Patients With Carotid Atherosclerosis", volume = "24", number = "4", pages = "246-251", doi = "10.1002/jcla.20393" }
Đurić, T., Živković, M., Stanković, A., Kolaković, A., Jekić, Đ., Selaković, V.,& Alavantić, D.. (2010). Plasma Levels of Matrix Metalloproteinase-8 in Patients With Carotid Atherosclerosis. in Journal of Clinical Laboratory Analysis, 24(4), 246-251. https://doi.org/10.1002/jcla.20393
Đurić T, Živković M, Stanković A, Kolaković A, Jekić Đ, Selaković V, Alavantić D. Plasma Levels of Matrix Metalloproteinase-8 in Patients With Carotid Atherosclerosis. in Journal of Clinical Laboratory Analysis. 2010;24(4):246-251. doi:10.1002/jcla.20393 .
Đurić, Tamara, Živković, Maja, Stanković, Aleksandra, Kolaković, Ana, Jekić, Đole, Selaković, Vesna, Alavantić, Dragan, "Plasma Levels of Matrix Metalloproteinase-8 in Patients With Carotid Atherosclerosis" in Journal of Clinical Laboratory Analysis, 24, no. 4 (2010):246-251, https://doi.org/10.1002/jcla.20393 . .