Diabetes and Antioxidants: Myth or Reality?
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Haidara, Mohamed A.Yassin, Hanaa Z.
Žakula, Zorica
Mikhailidis, Dimitri P.
Isenović, Esma R.
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Numerous studies have shown that increased oxidative stress (OxS) is present in diabetic patients. There is evidence that this OxS can be increased before complications associated with diabetes mellitus (DM) occur. However, the role and influence of OxS in the initiation and progression of DM remains the subject of debate. It has been suggested that in DM, OxS is caused by increased production of reactive oxygen species (ROS), and associated with reduction in antioxidant defenses and altered cellular redox status. Acute and chronic OxS which could enhance the development of complications associated with DM. This review considers recent findings on the role of antioxidants in controlling OxS and the incidence of DM with emphasis on animal and human studies.
Keywords:
Diabetes / oxidative stress / antioxidants / statinsSource:
Current Vascular Pharmacology, 2010, 8, 5, 661-672Funding / projects:
- Kasr Al-Aini Research Center, Ministry of Science, Serbia [143030B]
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VinčaTY - JOUR AU - Haidara, Mohamed A. AU - Yassin, Hanaa Z. AU - Žakula, Zorica AU - Mikhailidis, Dimitri P. AU - Isenović, Esma R. PY - 2010 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4112 AB - Numerous studies have shown that increased oxidative stress (OxS) is present in diabetic patients. There is evidence that this OxS can be increased before complications associated with diabetes mellitus (DM) occur. However, the role and influence of OxS in the initiation and progression of DM remains the subject of debate. It has been suggested that in DM, OxS is caused by increased production of reactive oxygen species (ROS), and associated with reduction in antioxidant defenses and altered cellular redox status. Acute and chronic OxS which could enhance the development of complications associated with DM. This review considers recent findings on the role of antioxidants in controlling OxS and the incidence of DM with emphasis on animal and human studies. T2 - Current Vascular Pharmacology T1 - Diabetes and Antioxidants: Myth or Reality? VL - 8 IS - 5 SP - 661 EP - 672 UR - https://hdl.handle.net/21.15107/rcub_vinar_4112 ER -
@article{ author = "Haidara, Mohamed A. and Yassin, Hanaa Z. and Žakula, Zorica and Mikhailidis, Dimitri P. and Isenović, Esma R.", year = "2010", abstract = "Numerous studies have shown that increased oxidative stress (OxS) is present in diabetic patients. There is evidence that this OxS can be increased before complications associated with diabetes mellitus (DM) occur. However, the role and influence of OxS in the initiation and progression of DM remains the subject of debate. It has been suggested that in DM, OxS is caused by increased production of reactive oxygen species (ROS), and associated with reduction in antioxidant defenses and altered cellular redox status. Acute and chronic OxS which could enhance the development of complications associated with DM. This review considers recent findings on the role of antioxidants in controlling OxS and the incidence of DM with emphasis on animal and human studies.", journal = "Current Vascular Pharmacology", title = "Diabetes and Antioxidants: Myth or Reality?", volume = "8", number = "5", pages = "661-672", url = "https://hdl.handle.net/21.15107/rcub_vinar_4112" }
Haidara, M. A., Yassin, H. Z., Žakula, Z., Mikhailidis, D. P.,& Isenović, E. R.. (2010). Diabetes and Antioxidants: Myth or Reality?. in Current Vascular Pharmacology, 8(5), 661-672. https://hdl.handle.net/21.15107/rcub_vinar_4112
Haidara MA, Yassin HZ, Žakula Z, Mikhailidis DP, Isenović ER. Diabetes and Antioxidants: Myth or Reality?. in Current Vascular Pharmacology. 2010;8(5):661-672. https://hdl.handle.net/21.15107/rcub_vinar_4112 .
Haidara, Mohamed A., Yassin, Hanaa Z., Žakula, Zorica, Mikhailidis, Dimitri P., Isenović, Esma R., "Diabetes and Antioxidants: Myth or Reality?" in Current Vascular Pharmacology, 8, no. 5 (2010):661-672, https://hdl.handle.net/21.15107/rcub_vinar_4112 .