Frequency of Aberrant Promoter Methylation of P15(Ink4b) and O-6-Methylguanine-Dna Methyltransferase Genes in B-Cell Non-Hodgkin Lymphoma: a Pilot Study
2010
Autori
Kurtovic, Nada KraguljacKrajnović, Milena M.
Dimitrijević, Bogomir B.
Mihaljevic, Biljana
Gotić, Mirjana
Krtolica-Žikić, Koviljka
Članak u časopisu
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The methylation status of the target promoter sequences of p15(INK4B) (p15) and O-6-methylguanine-DNA methyltransferase (MGMT) genes was studied by methylation-specific PCR in 10 adult patients with de novo B-cell non-Hodgkin lymphoma (B-NHL). The aberrant hypermethylation of the p15 gene was more frequent (50%) compared to the hypermethylation of the MGMT gene (30%), and was detected in different types of B-NHL in both genes. Hypermethylation of the MGMT gene occurred exclusively in association with the hypermethylation of the p15 gene. All lymphoma patients with hypermethylation of the p15 and/or MGMT genes had a higher clinical stage of the disease (IV - V). We show the association of anemia and/or thrombocytopenia with the hypermethylation of the p15 gene, ascribing the p15 gene as a potential prognostic marker in B-NHL. Comethylation of MGMT with the p15 gene represents a novel finding and presents both genes as candidates for future studies of the hypermethylation profiles of B-N...HL.
Ključne reči:
Methylation status / p15(INK4B) / O-6-methylguanine-DNA methyltransferase / B-cell non-Hodgkin lymphomaIzvor:
Archives of Biological Sciences, 2010, 62, 2, 211-221Finansiranje / projekti:
- Ministry of Science and Technology of the Republic of Serbia [143010]
DOI: 10.2298/ABS1002211K
ISSN: 0354-4664
WoS: 000280017400002
Scopus: 2-s2.0-77955148901
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Kurtovic, Nada Kraguljac AU - Krajnović, Milena M. AU - Dimitrijević, Bogomir B. AU - Mihaljevic, Biljana AU - Gotić, Mirjana AU - Krtolica-Žikić, Koviljka PY - 2010 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4045 AB - The methylation status of the target promoter sequences of p15(INK4B) (p15) and O-6-methylguanine-DNA methyltransferase (MGMT) genes was studied by methylation-specific PCR in 10 adult patients with de novo B-cell non-Hodgkin lymphoma (B-NHL). The aberrant hypermethylation of the p15 gene was more frequent (50%) compared to the hypermethylation of the MGMT gene (30%), and was detected in different types of B-NHL in both genes. Hypermethylation of the MGMT gene occurred exclusively in association with the hypermethylation of the p15 gene. All lymphoma patients with hypermethylation of the p15 and/or MGMT genes had a higher clinical stage of the disease (IV - V). We show the association of anemia and/or thrombocytopenia with the hypermethylation of the p15 gene, ascribing the p15 gene as a potential prognostic marker in B-NHL. Comethylation of MGMT with the p15 gene represents a novel finding and presents both genes as candidates for future studies of the hypermethylation profiles of B-NHL. T2 - Archives of Biological Sciences T1 - Frequency of Aberrant Promoter Methylation of P15(Ink4b) and O-6-Methylguanine-Dna Methyltransferase Genes in B-Cell Non-Hodgkin Lymphoma: a Pilot Study VL - 62 IS - 2 SP - 211 EP - 221 DO - 10.2298/ABS1002211K ER -
@article{ author = "Kurtovic, Nada Kraguljac and Krajnović, Milena M. and Dimitrijević, Bogomir B. and Mihaljevic, Biljana and Gotić, Mirjana and Krtolica-Žikić, Koviljka", year = "2010", abstract = "The methylation status of the target promoter sequences of p15(INK4B) (p15) and O-6-methylguanine-DNA methyltransferase (MGMT) genes was studied by methylation-specific PCR in 10 adult patients with de novo B-cell non-Hodgkin lymphoma (B-NHL). The aberrant hypermethylation of the p15 gene was more frequent (50%) compared to the hypermethylation of the MGMT gene (30%), and was detected in different types of B-NHL in both genes. Hypermethylation of the MGMT gene occurred exclusively in association with the hypermethylation of the p15 gene. All lymphoma patients with hypermethylation of the p15 and/or MGMT genes had a higher clinical stage of the disease (IV - V). We show the association of anemia and/or thrombocytopenia with the hypermethylation of the p15 gene, ascribing the p15 gene as a potential prognostic marker in B-NHL. Comethylation of MGMT with the p15 gene represents a novel finding and presents both genes as candidates for future studies of the hypermethylation profiles of B-NHL.", journal = "Archives of Biological Sciences", title = "Frequency of Aberrant Promoter Methylation of P15(Ink4b) and O-6-Methylguanine-Dna Methyltransferase Genes in B-Cell Non-Hodgkin Lymphoma: a Pilot Study", volume = "62", number = "2", pages = "211-221", doi = "10.2298/ABS1002211K" }
Kurtovic, N. K., Krajnović, M. M., Dimitrijević, B. B., Mihaljevic, B., Gotić, M.,& Krtolica-Žikić, K.. (2010). Frequency of Aberrant Promoter Methylation of P15(Ink4b) and O-6-Methylguanine-Dna Methyltransferase Genes in B-Cell Non-Hodgkin Lymphoma: a Pilot Study. in Archives of Biological Sciences, 62(2), 211-221. https://doi.org/10.2298/ABS1002211K
Kurtovic NK, Krajnović MM, Dimitrijević BB, Mihaljevic B, Gotić M, Krtolica-Žikić K. Frequency of Aberrant Promoter Methylation of P15(Ink4b) and O-6-Methylguanine-Dna Methyltransferase Genes in B-Cell Non-Hodgkin Lymphoma: a Pilot Study. in Archives of Biological Sciences. 2010;62(2):211-221. doi:10.2298/ABS1002211K .
Kurtovic, Nada Kraguljac, Krajnović, Milena M., Dimitrijević, Bogomir B., Mihaljevic, Biljana, Gotić, Mirjana, Krtolica-Žikić, Koviljka, "Frequency of Aberrant Promoter Methylation of P15(Ink4b) and O-6-Methylguanine-Dna Methyltransferase Genes in B-Cell Non-Hodgkin Lymphoma: a Pilot Study" in Archives of Biological Sciences, 62, no. 2 (2010):211-221, https://doi.org/10.2298/ABS1002211K . .