Levels of sCD40 Ligand in Chronic and Acute Coronary Syndromes and its Relation to Angiographic Extent of Coronary Arterial Narrowing
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Fouad, Hanan H.Al-Dera, Husain
Bakhoum, Sameh W.
Rashed, Laila A.
Sayed, Rehab H.
Rateb, Moshira A.
Haidara, Mohamed A.
Soskić, Sanja S.
Isenović, Esma R.
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We determined the serum levels of soluble CD40 ligand (sCD4OL) in patients with chronic coronary artery disease (CAD) and acute coronary syndrome (ACS). Patients with unstable angina (UA) and myocardial infarction (MI) showed significantly higher levels (P LT .001) of sCD4OL compared with patients with stable angina (SA) and controls; particularly, high levels occurred in patients with UA (UA: 9.23 +/- 2.92, MI: 7.38 +/- 1.05, SA: 4.42 +/- 1.08; control: 4.01 +/- 0.87 ng/mL). There was no significant difference in sCD4OL levels between patients with UA and MI or between patients with SA and controls. Levels of sCD4OL did not show any significant correlation with peak creatine kinase (CK), CK-MB isoenzyme activity in patients with MI, troponin T serum levels in patients with UA or with culprit vessel (CV) complexity score (CVCS), type of CV lesion, or vessel score in patients with UA or MI. These results suggest that CD40L plays a pathogenic role in triggering ACS.
Keywords:
coronary artery disease / acute coronary syndrome / CD40 ligand / coronary angiogramSource:
Angiology, 2010, 61, 6, 567-573Funding / projects:
- Research Center, Faculty of Medicine, Cairo University, Egypt, Ministry of Science, Republic of Serbia [143030]
DOI: 10.1177/0003319709356785
ISSN: 0003-3197
PubMed: 20304868
WoS: 000279760800008
Scopus: 2-s2.0-77955020141
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VinčaTY - JOUR AU - Fouad, Hanan H. AU - Al-Dera, Husain AU - Bakhoum, Sameh W. AU - Rashed, Laila A. AU - Sayed, Rehab H. AU - Rateb, Moshira A. AU - Haidara, Mohamed A. AU - Soskić, Sanja S. AU - Isenović, Esma R. PY - 2010 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4039 AB - We determined the serum levels of soluble CD40 ligand (sCD4OL) in patients with chronic coronary artery disease (CAD) and acute coronary syndrome (ACS). Patients with unstable angina (UA) and myocardial infarction (MI) showed significantly higher levels (P LT .001) of sCD4OL compared with patients with stable angina (SA) and controls; particularly, high levels occurred in patients with UA (UA: 9.23 +/- 2.92, MI: 7.38 +/- 1.05, SA: 4.42 +/- 1.08; control: 4.01 +/- 0.87 ng/mL). There was no significant difference in sCD4OL levels between patients with UA and MI or between patients with SA and controls. Levels of sCD4OL did not show any significant correlation with peak creatine kinase (CK), CK-MB isoenzyme activity in patients with MI, troponin T serum levels in patients with UA or with culprit vessel (CV) complexity score (CVCS), type of CV lesion, or vessel score in patients with UA or MI. These results suggest that CD40L plays a pathogenic role in triggering ACS. T2 - Angiology T1 - Levels of sCD40 Ligand in Chronic and Acute Coronary Syndromes and its Relation to Angiographic Extent of Coronary Arterial Narrowing VL - 61 IS - 6 SP - 567 EP - 573 DO - 10.1177/0003319709356785 ER -
@article{ author = "Fouad, Hanan H. and Al-Dera, Husain and Bakhoum, Sameh W. and Rashed, Laila A. and Sayed, Rehab H. and Rateb, Moshira A. and Haidara, Mohamed A. and Soskić, Sanja S. and Isenović, Esma R.", year = "2010", abstract = "We determined the serum levels of soluble CD40 ligand (sCD4OL) in patients with chronic coronary artery disease (CAD) and acute coronary syndrome (ACS). Patients with unstable angina (UA) and myocardial infarction (MI) showed significantly higher levels (P LT .001) of sCD4OL compared with patients with stable angina (SA) and controls; particularly, high levels occurred in patients with UA (UA: 9.23 +/- 2.92, MI: 7.38 +/- 1.05, SA: 4.42 +/- 1.08; control: 4.01 +/- 0.87 ng/mL). There was no significant difference in sCD4OL levels between patients with UA and MI or between patients with SA and controls. Levels of sCD4OL did not show any significant correlation with peak creatine kinase (CK), CK-MB isoenzyme activity in patients with MI, troponin T serum levels in patients with UA or with culprit vessel (CV) complexity score (CVCS), type of CV lesion, or vessel score in patients with UA or MI. These results suggest that CD40L plays a pathogenic role in triggering ACS.", journal = "Angiology", title = "Levels of sCD40 Ligand in Chronic and Acute Coronary Syndromes and its Relation to Angiographic Extent of Coronary Arterial Narrowing", volume = "61", number = "6", pages = "567-573", doi = "10.1177/0003319709356785" }
Fouad, H. H., Al-Dera, H., Bakhoum, S. W., Rashed, L. A., Sayed, R. H., Rateb, M. A., Haidara, M. A., Soskić, S. S.,& Isenović, E. R.. (2010). Levels of sCD40 Ligand in Chronic and Acute Coronary Syndromes and its Relation to Angiographic Extent of Coronary Arterial Narrowing. in Angiology, 61(6), 567-573. https://doi.org/10.1177/0003319709356785
Fouad HH, Al-Dera H, Bakhoum SW, Rashed LA, Sayed RH, Rateb MA, Haidara MA, Soskić SS, Isenović ER. Levels of sCD40 Ligand in Chronic and Acute Coronary Syndromes and its Relation to Angiographic Extent of Coronary Arterial Narrowing. in Angiology. 2010;61(6):567-573. doi:10.1177/0003319709356785 .
Fouad, Hanan H., Al-Dera, Husain, Bakhoum, Sameh W., Rashed, Laila A., Sayed, Rehab H., Rateb, Moshira A., Haidara, Mohamed A., Soskić, Sanja S., Isenović, Esma R., "Levels of sCD40 Ligand in Chronic and Acute Coronary Syndromes and its Relation to Angiographic Extent of Coronary Arterial Narrowing" in Angiology, 61, no. 6 (2010):567-573, https://doi.org/10.1177/0003319709356785 . .
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