Thrombocytopenia in Patients With Chronic Hepatitis C: A Possible Role of HCV on Platelet Progenitor Cell Maturation
Nema prikaza
Autori
El Barbary, Magdy A.Saad, Alaa Eldin M.
Attia, Fadia M.
Mandour, Magda I.
Haidara, Mohamed A.
Dallak, Mohammad M.
Isenović, Esma R.
Članak u časopisu
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
A total of 30 patients with chronic hepatitis C (HCV) thrombocytopenia (TP) and 20 healthy controls were studied. Both groups were subjected to complete medical history, clinical examination in addition to assessment of hepatitis markers: level of thrombopoietin (Tpo), Geimsa-stained bone marrow smears, and in vitro short-term megakaryocytic progenitors culture (CFU-MK). Serum Tpo level was significantly elevated in patients with TP HCV. Short-term CFU-MK showed an evident depression in the colony-forming unit-megakaryocyte (CFU-meg). There is a positive correlation between the number of CFU-meg and the platelet count and between serum Tpo level and prothrombin time, transaminase, albumin, and the Child Pugh score of liver disease; a negative correlation between serum Tpo level and the number of CFU-meg and between serum Tpo level and the platelet count. Thus, the level of Tpo could be an indicator of intact functional response of the hepatocytes.
Ključne reči:
short-term megakaryocytic progenitors culture (CFU-MK) / thrombopoietin / hepatitis C / thrombocytopeniaIzvor:
Angiology, 2010, 61, 3, 304-313Finansiranje / projekti:
- Ministry of Science, Republic of Serbia [143030]
DOI: 10.1177/0003319709343178
ISSN: 0003-3197
PubMed: 19689996
WoS: 000275737700013
Scopus: 2-s2.0-77949900771
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - El Barbary, Magdy A. AU - Saad, Alaa Eldin M. AU - Attia, Fadia M. AU - Mandour, Magda I. AU - Haidara, Mohamed A. AU - Dallak, Mohammad M. AU - Isenović, Esma R. PY - 2010 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3932 AB - A total of 30 patients with chronic hepatitis C (HCV) thrombocytopenia (TP) and 20 healthy controls were studied. Both groups were subjected to complete medical history, clinical examination in addition to assessment of hepatitis markers: level of thrombopoietin (Tpo), Geimsa-stained bone marrow smears, and in vitro short-term megakaryocytic progenitors culture (CFU-MK). Serum Tpo level was significantly elevated in patients with TP HCV. Short-term CFU-MK showed an evident depression in the colony-forming unit-megakaryocyte (CFU-meg). There is a positive correlation between the number of CFU-meg and the platelet count and between serum Tpo level and prothrombin time, transaminase, albumin, and the Child Pugh score of liver disease; a negative correlation between serum Tpo level and the number of CFU-meg and between serum Tpo level and the platelet count. Thus, the level of Tpo could be an indicator of intact functional response of the hepatocytes. T2 - Angiology T1 - Thrombocytopenia in Patients With Chronic Hepatitis C: A Possible Role of HCV on Platelet Progenitor Cell Maturation VL - 61 IS - 3 SP - 304 EP - 313 DO - 10.1177/0003319709343178 ER -
@article{ author = "El Barbary, Magdy A. and Saad, Alaa Eldin M. and Attia, Fadia M. and Mandour, Magda I. and Haidara, Mohamed A. and Dallak, Mohammad M. and Isenović, Esma R.", year = "2010", abstract = "A total of 30 patients with chronic hepatitis C (HCV) thrombocytopenia (TP) and 20 healthy controls were studied. Both groups were subjected to complete medical history, clinical examination in addition to assessment of hepatitis markers: level of thrombopoietin (Tpo), Geimsa-stained bone marrow smears, and in vitro short-term megakaryocytic progenitors culture (CFU-MK). Serum Tpo level was significantly elevated in patients with TP HCV. Short-term CFU-MK showed an evident depression in the colony-forming unit-megakaryocyte (CFU-meg). There is a positive correlation between the number of CFU-meg and the platelet count and between serum Tpo level and prothrombin time, transaminase, albumin, and the Child Pugh score of liver disease; a negative correlation between serum Tpo level and the number of CFU-meg and between serum Tpo level and the platelet count. Thus, the level of Tpo could be an indicator of intact functional response of the hepatocytes.", journal = "Angiology", title = "Thrombocytopenia in Patients With Chronic Hepatitis C: A Possible Role of HCV on Platelet Progenitor Cell Maturation", volume = "61", number = "3", pages = "304-313", doi = "10.1177/0003319709343178" }
El Barbary, M. A., Saad, A. E. M., Attia, F. M., Mandour, M. I., Haidara, M. A., Dallak, M. M.,& Isenović, E. R.. (2010). Thrombocytopenia in Patients With Chronic Hepatitis C: A Possible Role of HCV on Platelet Progenitor Cell Maturation. in Angiology, 61(3), 304-313. https://doi.org/10.1177/0003319709343178
El Barbary MA, Saad AEM, Attia FM, Mandour MI, Haidara MA, Dallak MM, Isenović ER. Thrombocytopenia in Patients With Chronic Hepatitis C: A Possible Role of HCV on Platelet Progenitor Cell Maturation. in Angiology. 2010;61(3):304-313. doi:10.1177/0003319709343178 .
El Barbary, Magdy A., Saad, Alaa Eldin M., Attia, Fadia M., Mandour, Magda I., Haidara, Mohamed A., Dallak, Mohammad M., Isenović, Esma R., "Thrombocytopenia in Patients With Chronic Hepatitis C: A Possible Role of HCV on Platelet Progenitor Cell Maturation" in Angiology, 61, no. 3 (2010):304-313, https://doi.org/10.1177/0003319709343178 . .