Flavonoids as matrices for MALDI-TOF mass spectrometric analysis of transition metal complexes
No Thumbnail
Authors
Petković, MarijanaPetrović, Biljana
Savić, Jasmina
Bugarčić, Živadin D.
Dimitrić-Marković, Jasmina
Momić, Tatjana
Vasić, Vesna M.
Article
Metadata
Show full item recordAbstract
Matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a suitable method for the analysis of inorganic and organic compounds and biomolecules This makes. MALDI-TOF MS convenient for monitoring the interaction of metallo-drugs with biomolecules. Results presented in this manuscript demonstrate that flavonoids such as apigenin, kaempferol and luteolin are suitable for MALDI-TOF MS analysis of Pt(II), Pd(II), Pt(IV) and Ru(III) complexes, giving different signal-to-noise ratios of the analyte peak. The MALDI-TOF mass spectra of inorganic complexes acquired with these flavonoid matrices are easy to interpret and have some advantages over the application of other commonly used matrices: a low number of matrix peaks are detectable and the coordinative metal-ligand bond is, in most cases, preserved. On the other hand, flavonoids do not act as typical matrices, as their excess is not required for the acquisition of MALDI-TOF mass spectra of inorganic... complexes. (C) 2009 Elsevier B.V. All rights reserved.
Keywords:
Ru(III) complex / Pt-complex / Pd complex / MALDI-TOF MS / FlavonoidSource:
International Journal of Mass Spectrometry, 2010, 290, 1, 39-46Funding / projects:
DOI: 10.1016/j.ijms.2009.12.001
ISSN: 1387-3806
WoS: 000274702600006
Scopus: 2-s2.0-74149090447
Collections
Institution/Community
VinčaTY - JOUR AU - Petković, Marijana AU - Petrović, Biljana AU - Savić, Jasmina AU - Bugarčić, Živadin D. AU - Dimitrić-Marković, Jasmina AU - Momić, Tatjana AU - Vasić, Vesna M. PY - 2010 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3909 AB - Matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a suitable method for the analysis of inorganic and organic compounds and biomolecules This makes. MALDI-TOF MS convenient for monitoring the interaction of metallo-drugs with biomolecules. Results presented in this manuscript demonstrate that flavonoids such as apigenin, kaempferol and luteolin are suitable for MALDI-TOF MS analysis of Pt(II), Pd(II), Pt(IV) and Ru(III) complexes, giving different signal-to-noise ratios of the analyte peak. The MALDI-TOF mass spectra of inorganic complexes acquired with these flavonoid matrices are easy to interpret and have some advantages over the application of other commonly used matrices: a low number of matrix peaks are detectable and the coordinative metal-ligand bond is, in most cases, preserved. On the other hand, flavonoids do not act as typical matrices, as their excess is not required for the acquisition of MALDI-TOF mass spectra of inorganic complexes. (C) 2009 Elsevier B.V. All rights reserved. T2 - International Journal of Mass Spectrometry T1 - Flavonoids as matrices for MALDI-TOF mass spectrometric analysis of transition metal complexes VL - 290 IS - 1 SP - 39 EP - 46 DO - 10.1016/j.ijms.2009.12.001 ER -
@article{ author = "Petković, Marijana and Petrović, Biljana and Savić, Jasmina and Bugarčić, Živadin D. and Dimitrić-Marković, Jasmina and Momić, Tatjana and Vasić, Vesna M.", year = "2010", abstract = "Matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a suitable method for the analysis of inorganic and organic compounds and biomolecules This makes. MALDI-TOF MS convenient for monitoring the interaction of metallo-drugs with biomolecules. Results presented in this manuscript demonstrate that flavonoids such as apigenin, kaempferol and luteolin are suitable for MALDI-TOF MS analysis of Pt(II), Pd(II), Pt(IV) and Ru(III) complexes, giving different signal-to-noise ratios of the analyte peak. The MALDI-TOF mass spectra of inorganic complexes acquired with these flavonoid matrices are easy to interpret and have some advantages over the application of other commonly used matrices: a low number of matrix peaks are detectable and the coordinative metal-ligand bond is, in most cases, preserved. On the other hand, flavonoids do not act as typical matrices, as their excess is not required for the acquisition of MALDI-TOF mass spectra of inorganic complexes. (C) 2009 Elsevier B.V. All rights reserved.", journal = "International Journal of Mass Spectrometry", title = "Flavonoids as matrices for MALDI-TOF mass spectrometric analysis of transition metal complexes", volume = "290", number = "1", pages = "39-46", doi = "10.1016/j.ijms.2009.12.001" }
Petković, M., Petrović, B., Savić, J., Bugarčić, Ž. D., Dimitrić-Marković, J., Momić, T.,& Vasić, V. M.. (2010). Flavonoids as matrices for MALDI-TOF mass spectrometric analysis of transition metal complexes. in International Journal of Mass Spectrometry, 290(1), 39-46. https://doi.org/10.1016/j.ijms.2009.12.001
Petković M, Petrović B, Savić J, Bugarčić ŽD, Dimitrić-Marković J, Momić T, Vasić VM. Flavonoids as matrices for MALDI-TOF mass spectrometric analysis of transition metal complexes. in International Journal of Mass Spectrometry. 2010;290(1):39-46. doi:10.1016/j.ijms.2009.12.001 .
Petković, Marijana, Petrović, Biljana, Savić, Jasmina, Bugarčić, Živadin D., Dimitrić-Marković, Jasmina, Momić, Tatjana, Vasić, Vesna M., "Flavonoids as matrices for MALDI-TOF mass spectrometric analysis of transition metal complexes" in International Journal of Mass Spectrometry, 290, no. 1 (2010):39-46, https://doi.org/10.1016/j.ijms.2009.12.001 . .