Cardiac Adaptive Responses After Hypoxia in an Experimental Model
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Bin-Jaliah, IsmaeelAmmar, Hania I.
Mikhailidis, Dimitri P.
Dallak, Mohammed A.
Al-Hashem, Fahaid H.
Haidara, Mohamed A.
Yassin, Hanaa Z.
Bahnasi, Abeer A.
Rashed, Laila A.
Isenović, Esma R.
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The role of vascular endothelial growth factor (VEGF) and erythropoietin (EPO) in mediating hypoxic preconditioning under the acute intermittent hypoxic condition (AIH) was investigated in this study. Male Wistar rats were randomly assigned and kept in normoxic conditions, (Nx) or in AIH conditions and subjected to brief cycles hypoxia/reoxygenation. Hearts were isolated, perfused, and subjected to in vitro global ischemia followed by reperfusion. During and at the end of reperfusion, left ventricular developed pressure (LVDP); LV end diastolic pressure (LVEDP); rate pressure product (RPP); peak left ventricular pressure rise (Delta P/Delta t(max)) and heart rate (HR) were measured. Hearts subjected to AIH displayed a significant higher LVDP (P LT .001), RPP (P LT .001), and Delta P/Delta t(max) (P LT .001). Expression of VEGF and EPO were significantly increased at 3, 8, and 24 hours after AIH. Hypoxic training could provide a new approach to enhance endogenous cardioprotective mechan...isms.
Keywords:
acute intermittent hypoxia / hypoxic preconditioning / vascular endothelial growth factor / erythropoietinSource:
Angiology, 2010, 61, 2, 145-156
DOI: 10.1177/0003319709352486
ISSN: 0003-3197
PubMed: 19939823
WoS: 000274024100004
Scopus: 2-s2.0-76649129859
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VinčaTY - JOUR AU - Bin-Jaliah, Ismaeel AU - Ammar, Hania I. AU - Mikhailidis, Dimitri P. AU - Dallak, Mohammed A. AU - Al-Hashem, Fahaid H. AU - Haidara, Mohamed A. AU - Yassin, Hanaa Z. AU - Bahnasi, Abeer A. AU - Rashed, Laila A. AU - Isenović, Esma R. PY - 2010 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3883 AB - The role of vascular endothelial growth factor (VEGF) and erythropoietin (EPO) in mediating hypoxic preconditioning under the acute intermittent hypoxic condition (AIH) was investigated in this study. Male Wistar rats were randomly assigned and kept in normoxic conditions, (Nx) or in AIH conditions and subjected to brief cycles hypoxia/reoxygenation. Hearts were isolated, perfused, and subjected to in vitro global ischemia followed by reperfusion. During and at the end of reperfusion, left ventricular developed pressure (LVDP); LV end diastolic pressure (LVEDP); rate pressure product (RPP); peak left ventricular pressure rise (Delta P/Delta t(max)) and heart rate (HR) were measured. Hearts subjected to AIH displayed a significant higher LVDP (P LT .001), RPP (P LT .001), and Delta P/Delta t(max) (P LT .001). Expression of VEGF and EPO were significantly increased at 3, 8, and 24 hours after AIH. Hypoxic training could provide a new approach to enhance endogenous cardioprotective mechanisms. T2 - Angiology T1 - Cardiac Adaptive Responses After Hypoxia in an Experimental Model VL - 61 IS - 2 SP - 145 EP - 156 DO - 10.1177/0003319709352486 ER -
@article{ author = "Bin-Jaliah, Ismaeel and Ammar, Hania I. and Mikhailidis, Dimitri P. and Dallak, Mohammed A. and Al-Hashem, Fahaid H. and Haidara, Mohamed A. and Yassin, Hanaa Z. and Bahnasi, Abeer A. and Rashed, Laila A. and Isenović, Esma R.", year = "2010", abstract = "The role of vascular endothelial growth factor (VEGF) and erythropoietin (EPO) in mediating hypoxic preconditioning under the acute intermittent hypoxic condition (AIH) was investigated in this study. Male Wistar rats were randomly assigned and kept in normoxic conditions, (Nx) or in AIH conditions and subjected to brief cycles hypoxia/reoxygenation. Hearts were isolated, perfused, and subjected to in vitro global ischemia followed by reperfusion. During and at the end of reperfusion, left ventricular developed pressure (LVDP); LV end diastolic pressure (LVEDP); rate pressure product (RPP); peak left ventricular pressure rise (Delta P/Delta t(max)) and heart rate (HR) were measured. Hearts subjected to AIH displayed a significant higher LVDP (P LT .001), RPP (P LT .001), and Delta P/Delta t(max) (P LT .001). Expression of VEGF and EPO were significantly increased at 3, 8, and 24 hours after AIH. Hypoxic training could provide a new approach to enhance endogenous cardioprotective mechanisms.", journal = "Angiology", title = "Cardiac Adaptive Responses After Hypoxia in an Experimental Model", volume = "61", number = "2", pages = "145-156", doi = "10.1177/0003319709352486" }
Bin-Jaliah, I., Ammar, H. I., Mikhailidis, D. P., Dallak, M. A., Al-Hashem, F. H., Haidara, M. A., Yassin, H. Z., Bahnasi, A. A., Rashed, L. A.,& Isenović, E. R.. (2010). Cardiac Adaptive Responses After Hypoxia in an Experimental Model. in Angiology, 61(2), 145-156. https://doi.org/10.1177/0003319709352486
Bin-Jaliah I, Ammar HI, Mikhailidis DP, Dallak MA, Al-Hashem FH, Haidara MA, Yassin HZ, Bahnasi AA, Rashed LA, Isenović ER. Cardiac Adaptive Responses After Hypoxia in an Experimental Model. in Angiology. 2010;61(2):145-156. doi:10.1177/0003319709352486 .
Bin-Jaliah, Ismaeel, Ammar, Hania I., Mikhailidis, Dimitri P., Dallak, Mohammed A., Al-Hashem, Fahaid H., Haidara, Mohamed A., Yassin, Hanaa Z., Bahnasi, Abeer A., Rashed, Laila A., Isenović, Esma R., "Cardiac Adaptive Responses After Hypoxia in an Experimental Model" in Angiology, 61, no. 2 (2010):145-156, https://doi.org/10.1177/0003319709352486 . .