V-79 Chinese Hamster cells irradiated with antiprotons, a study of peripheral damage due to medium and long range components of the annihilation radiation
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Аутори
Kovacevic, SandraBassler, Niels
Hartley, Oliver
Knudsen, Helge V.
Vranješ, Sanja
Garaj-Vrhovac, Vera
Holzscheiter, Michael H.
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Purpose: Radiotherapy of cancer carries a perceived risk of inducing secondary cancer and other damage due to dose delivered to normal tissue. While expectedly small, this risk must be carefully analysed for all modalities. Especially in the use of exotic particles like pions and antiprotons, which annihilate and produce a mixed radiation field when interacting with normal matter nuclei, the biological effective dose far out of field needs to be considered in evaluating this approach. We describe first biological measurements to address the concern that medium and long range annihilation products may produce a significant background dose and reverse any benefits of higher biological dose in the target area. Materials and methods: Using the Antiproton Decelerator (AD) at CERN (Conseil Europeen pour la Recherche Nucleaire) we irradiated V-79 Chinese Hamster cells embedded in gelatine using an antiproton beam with fluence ranging from 4.5 x 10(8) to 4.5 x 10(9) particles, and evaluated th...e biological effect on cells located distal to the Bragg peak using clonogenic survival and the COMET assay. Results: Both methods show a substantial biological effect on the cells in the entrance channel and the Bragg Peak area, but any damage is reduced to levels well below the effect in the entrance channel 15 mm distal to the Bragg peak for even the highest particle fluence used. Conclusions: The annihilation radiation generated by antiprotons stopping in biological targets causes an increase of the penumbra of the beam but the effect rapidly decreases with distance from the target volume. No major increase in the biological effect is found in the far field outside of the primary beam.
Кључне речи:
antiprotons / comet assay / clonogenic assay / DNA damageИзвор:
International Journal of Radiation Biology, 2009, 85, 12, 1148-1156Финансирање / пројекти:
- The Danish Cancer Society
DOI: 10.3109/09553000903242081
ISSN: 0955-3002
PubMed: 19995240
WoS: 000273115000008
Scopus: 2-s2.0-72049130279
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Институција/група
VinčaTY - JOUR AU - Kovacevic, Sandra AU - Bassler, Niels AU - Hartley, Oliver AU - Knudsen, Helge V. AU - Vranješ, Sanja AU - Garaj-Vrhovac, Vera AU - Holzscheiter, Michael H. PY - 2009 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3854 AB - Purpose: Radiotherapy of cancer carries a perceived risk of inducing secondary cancer and other damage due to dose delivered to normal tissue. While expectedly small, this risk must be carefully analysed for all modalities. Especially in the use of exotic particles like pions and antiprotons, which annihilate and produce a mixed radiation field when interacting with normal matter nuclei, the biological effective dose far out of field needs to be considered in evaluating this approach. We describe first biological measurements to address the concern that medium and long range annihilation products may produce a significant background dose and reverse any benefits of higher biological dose in the target area. Materials and methods: Using the Antiproton Decelerator (AD) at CERN (Conseil Europeen pour la Recherche Nucleaire) we irradiated V-79 Chinese Hamster cells embedded in gelatine using an antiproton beam with fluence ranging from 4.5 x 10(8) to 4.5 x 10(9) particles, and evaluated the biological effect on cells located distal to the Bragg peak using clonogenic survival and the COMET assay. Results: Both methods show a substantial biological effect on the cells in the entrance channel and the Bragg Peak area, but any damage is reduced to levels well below the effect in the entrance channel 15 mm distal to the Bragg peak for even the highest particle fluence used. Conclusions: The annihilation radiation generated by antiprotons stopping in biological targets causes an increase of the penumbra of the beam but the effect rapidly decreases with distance from the target volume. No major increase in the biological effect is found in the far field outside of the primary beam. T2 - International Journal of Radiation Biology T1 - V-79 Chinese Hamster cells irradiated with antiprotons, a study of peripheral damage due to medium and long range components of the annihilation radiation VL - 85 IS - 12 SP - 1148 EP - 1156 DO - 10.3109/09553000903242081 ER -
@article{ author = "Kovacevic, Sandra and Bassler, Niels and Hartley, Oliver and Knudsen, Helge V. and Vranješ, Sanja and Garaj-Vrhovac, Vera and Holzscheiter, Michael H.", year = "2009", abstract = "Purpose: Radiotherapy of cancer carries a perceived risk of inducing secondary cancer and other damage due to dose delivered to normal tissue. While expectedly small, this risk must be carefully analysed for all modalities. Especially in the use of exotic particles like pions and antiprotons, which annihilate and produce a mixed radiation field when interacting with normal matter nuclei, the biological effective dose far out of field needs to be considered in evaluating this approach. We describe first biological measurements to address the concern that medium and long range annihilation products may produce a significant background dose and reverse any benefits of higher biological dose in the target area. Materials and methods: Using the Antiproton Decelerator (AD) at CERN (Conseil Europeen pour la Recherche Nucleaire) we irradiated V-79 Chinese Hamster cells embedded in gelatine using an antiproton beam with fluence ranging from 4.5 x 10(8) to 4.5 x 10(9) particles, and evaluated the biological effect on cells located distal to the Bragg peak using clonogenic survival and the COMET assay. Results: Both methods show a substantial biological effect on the cells in the entrance channel and the Bragg Peak area, but any damage is reduced to levels well below the effect in the entrance channel 15 mm distal to the Bragg peak for even the highest particle fluence used. Conclusions: The annihilation radiation generated by antiprotons stopping in biological targets causes an increase of the penumbra of the beam but the effect rapidly decreases with distance from the target volume. No major increase in the biological effect is found in the far field outside of the primary beam.", journal = "International Journal of Radiation Biology", title = "V-79 Chinese Hamster cells irradiated with antiprotons, a study of peripheral damage due to medium and long range components of the annihilation radiation", volume = "85", number = "12", pages = "1148-1156", doi = "10.3109/09553000903242081" }
Kovacevic, S., Bassler, N., Hartley, O., Knudsen, H. V., Vranješ, S., Garaj-Vrhovac, V.,& Holzscheiter, M. H.. (2009). V-79 Chinese Hamster cells irradiated with antiprotons, a study of peripheral damage due to medium and long range components of the annihilation radiation. in International Journal of Radiation Biology, 85(12), 1148-1156. https://doi.org/10.3109/09553000903242081
Kovacevic S, Bassler N, Hartley O, Knudsen HV, Vranješ S, Garaj-Vrhovac V, Holzscheiter MH. V-79 Chinese Hamster cells irradiated with antiprotons, a study of peripheral damage due to medium and long range components of the annihilation radiation. in International Journal of Radiation Biology. 2009;85(12):1148-1156. doi:10.3109/09553000903242081 .
Kovacevic, Sandra, Bassler, Niels, Hartley, Oliver, Knudsen, Helge V., Vranješ, Sanja, Garaj-Vrhovac, Vera, Holzscheiter, Michael H., "V-79 Chinese Hamster cells irradiated with antiprotons, a study of peripheral damage due to medium and long range components of the annihilation radiation" in International Journal of Radiation Biology, 85, no. 12 (2009):1148-1156, https://doi.org/10.3109/09553000903242081 . .