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Preparation and biodistribution of radiolabeled fullerene C-60 nanocrystals
dc.creator | Nikolić, Nadežda S. | |
dc.creator | Vranješ-Đurić, Sanja | |
dc.creator | Janković, Drina | |
dc.creator | Dokic, Divna | |
dc.creator | Mirković, Marija D. | |
dc.creator | Bibić, Nataša M. | |
dc.creator | Trajković, Vladimir S. | |
dc.date.accessioned | 2018-03-01T20:54:24Z | |
dc.date.available | 2018-03-01T20:54:24Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 0957-4484 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/3777 | |
dc.description.abstract | The present study describes for the first time a procedure for the radiolabeling of fullerene (C-60) nanocrystals (nanoC(60)) with Na I-125, as well as the biodistribution of radiolabeled nanoC(60) (I-125-nanoC(60)). The solvent exchange method with tetrahydrofuran was used to make colloidal water suspensions of radiolabeled nanoC(60) particles. The radiolabeling procedure with the addition of Na I-125 to tetrahydrofuran during dissolution of C-60 gave a higher radiochemical yield of radiolabeled nanoC(60) particles in comparison to the second option, in which Na I-125 was added after C-60 was dissolved. Using photon correlation spectroscopy and transmission electron microscopy, I-125-nanoC(60) particles were found to have a crystalline structure and a mean diameter of 200-250 nm. The I-125-nanoC(60) had a particularly high affinity for human serum albumin, displaying 95% binding efficiency after 1 h. Biodistribution studies of I-125-nanoC(60) in rats indicated significant differences in tissue accumulation of I-125-nanoC(60) and the radioactive tracer Na I-125. The higher accumulation of radiolabeled nanoC(60) was observed in liver and spleen, while accumulation in thyroid, stomach, lungs and intestines was significantly lower in comparison to Na I-125. In addition to being useful for testing the biological distribution of nanoC(60), the described radiolabeling procedure might have possible applications in cancer radiotherapy. | en |
dc.relation | Ministry of Science and Technology of the Republic of Serbia [145073, 169009] | |
dc.rights | restrictedAccess | en |
dc.source | Nanotechnology | en |
dc.title | Preparation and biodistribution of radiolabeled fullerene C-60 nanocrystals | en |
dc.type | article | en |
dcterms.abstract | Николиц, Надезда; Бибиц, Натаса; Трајковиц, Владимир; Докиц, Дивна; Врањеш-Дјурић Сања; Јанковић Дрина; Мирковић Марија; | |
dc.citation.volume | 20 | |
dc.citation.issue | 38 | |
dc.identifier.wos | 000269356900002 | |
dc.identifier.doi | 10.1088/0957-4484/20/38/385102 | |
dc.citation.other | Article Number: 385102 | |
dc.citation.rank | M21a | |
dc.identifier.pmid | 19713574 | |
dc.identifier.scopus | 2-s2.0-70349084624 |
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