Sequence Variability At the Internal Ribosome Entry Site of the Hcv Genome in Relation to Therapy Outcome
Нема приказа
Аутори
Jovanović-Ćupić, Snežana P.Simonovic-Babic, Jasmina
Blagojevic, Jelena
Božić, Milena
Ješić, Rada
Nozic, D.
Stamenković, Gorana
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт
Different types of interferon are widely used to treat hepatitis C virus (HCV) infection. Results obtained in vitro suggest that interferon inhibits internal ribosome entry site (IRES)-mediated translation of the HCV genome. To elucidate the possible effect of the nucleotide sequence of IRES on therapy outcome, we compared HCV isolates from patients with sustained response and non-response to interferon/ribavirin combination therapy. In 56 analyzed HCV isolates, nucleotide changes appeared strictly in the stem-loop IIIb region, the stem part from 243 nt to 248 nt, and the polypyrimidine-II region. The natural sequence variability of IRES in isolates of genotype 3a was significantly higher than in isolates of genotype 1b (p LT 0.05). The average number of nucleotide changes in genotype 3a correlated with response to therapy (p LT 0.05).
Кључне речи:
Hepatitis C virus / interferon / internal ribosome entry site / genotypes 1b and 3aИзвор:
Archives of Biological Sciences, 2009, 61, 2, 205-212Финансирање / пројекти:
- Ministry of Science and Environmental Protection of the Republic of Serbia [1430 10, 143011]
Колекције
Институција/група
VinčaTY - JOUR AU - Jovanović-Ćupić, Snežana P. AU - Simonovic-Babic, Jasmina AU - Blagojevic, Jelena AU - Božić, Milena AU - Ješić, Rada AU - Nozic, D. AU - Stamenković, Gorana PY - 2009 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3752 AB - Different types of interferon are widely used to treat hepatitis C virus (HCV) infection. Results obtained in vitro suggest that interferon inhibits internal ribosome entry site (IRES)-mediated translation of the HCV genome. To elucidate the possible effect of the nucleotide sequence of IRES on therapy outcome, we compared HCV isolates from patients with sustained response and non-response to interferon/ribavirin combination therapy. In 56 analyzed HCV isolates, nucleotide changes appeared strictly in the stem-loop IIIb region, the stem part from 243 nt to 248 nt, and the polypyrimidine-II region. The natural sequence variability of IRES in isolates of genotype 3a was significantly higher than in isolates of genotype 1b (p LT 0.05). The average number of nucleotide changes in genotype 3a correlated with response to therapy (p LT 0.05). T2 - Archives of Biological Sciences T1 - Sequence Variability At the Internal Ribosome Entry Site of the Hcv Genome in Relation to Therapy Outcome VL - 61 IS - 2 SP - 205 EP - 212 DO - 10.2298/ABS0901205J ER -
@article{ author = "Jovanović-Ćupić, Snežana P. and Simonovic-Babic, Jasmina and Blagojevic, Jelena and Božić, Milena and Ješić, Rada and Nozic, D. and Stamenković, Gorana", year = "2009", abstract = "Different types of interferon are widely used to treat hepatitis C virus (HCV) infection. Results obtained in vitro suggest that interferon inhibits internal ribosome entry site (IRES)-mediated translation of the HCV genome. To elucidate the possible effect of the nucleotide sequence of IRES on therapy outcome, we compared HCV isolates from patients with sustained response and non-response to interferon/ribavirin combination therapy. In 56 analyzed HCV isolates, nucleotide changes appeared strictly in the stem-loop IIIb region, the stem part from 243 nt to 248 nt, and the polypyrimidine-II region. The natural sequence variability of IRES in isolates of genotype 3a was significantly higher than in isolates of genotype 1b (p LT 0.05). The average number of nucleotide changes in genotype 3a correlated with response to therapy (p LT 0.05).", journal = "Archives of Biological Sciences", title = "Sequence Variability At the Internal Ribosome Entry Site of the Hcv Genome in Relation to Therapy Outcome", volume = "61", number = "2", pages = "205-212", doi = "10.2298/ABS0901205J" }
Jovanović-Ćupić, S. P., Simonovic-Babic, J., Blagojevic, J., Božić, M., Ješić, R., Nozic, D.,& Stamenković, G.. (2009). Sequence Variability At the Internal Ribosome Entry Site of the Hcv Genome in Relation to Therapy Outcome. in Archives of Biological Sciences, 61(2), 205-212. https://doi.org/10.2298/ABS0901205J
Jovanović-Ćupić SP, Simonovic-Babic J, Blagojevic J, Božić M, Ješić R, Nozic D, Stamenković G. Sequence Variability At the Internal Ribosome Entry Site of the Hcv Genome in Relation to Therapy Outcome. in Archives of Biological Sciences. 2009;61(2):205-212. doi:10.2298/ABS0901205J .
Jovanović-Ćupić, Snežana P., Simonovic-Babic, Jasmina, Blagojevic, Jelena, Božić, Milena, Ješić, Rada, Nozic, D., Stamenković, Gorana, "Sequence Variability At the Internal Ribosome Entry Site of the Hcv Genome in Relation to Therapy Outcome" in Archives of Biological Sciences, 61, no. 2 (2009):205-212, https://doi.org/10.2298/ABS0901205J . .