Characterization of conserved properties of hemagglutinin of H5N1 and human influenza viruses: possible consequences for therapy and infection control
2009
Autori
Veljković, VeljkoVeljković, Nevena V.
Muller, Claude P.
Mueller, Sybille
Glišić, Sanja
Perović, Vladimir R.
Koehler, Heinz
Članak u časopisu
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Background: Epidemics caused by highly pathogenic avian influenza virus (HPAIV) are a continuing threat to human health and to the worlds economy. The development of approaches, which help to understand the significance of structural changes resulting from the alarming mutational propensity for human-to-human transmission of HPAIV, is of particularly interest. Here we compare informational and structural properties of the hemagglutinin (HA) of H5N1 virus and human influenza virus subtypes, which are important for the receptor/virus interaction. Results: Presented results revealed that HA proteins encode highly conserved information that differ between influenza virus subtypes H5N1, H1N1, H3N2, H7N7 and defined an HA domain which may modulate interaction with receptor. We also found that about one third of H5N1 viruses which are isolated during the 2006/07 influenza outbreak in Egypt possibly evolve towards receptor usage similar to that of seasonal H1N1. Conclusion: The presented resul...ts may help to better understand the interaction of influenza virus with its receptor(s) and to identify new therapeutic targets for drug development.
Izvor:
BMC Structural Biology, 2009, 9Finansiranje / projekti:
- Ministry of Science and Technological Development of the Republic of Serbia [143001]
DOI: 10.1186/1472-6807-9-21
ISSN: 1471-2237
PubMed: 19351406
WoS: 000265931300001
Scopus: 2-s2.0-65549155359
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Veljković, Veljko AU - Veljković, Nevena V. AU - Muller, Claude P. AU - Mueller, Sybille AU - Glišić, Sanja AU - Perović, Vladimir R. AU - Koehler, Heinz PY - 2009 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3695 AB - Background: Epidemics caused by highly pathogenic avian influenza virus (HPAIV) are a continuing threat to human health and to the worlds economy. The development of approaches, which help to understand the significance of structural changes resulting from the alarming mutational propensity for human-to-human transmission of HPAIV, is of particularly interest. Here we compare informational and structural properties of the hemagglutinin (HA) of H5N1 virus and human influenza virus subtypes, which are important for the receptor/virus interaction. Results: Presented results revealed that HA proteins encode highly conserved information that differ between influenza virus subtypes H5N1, H1N1, H3N2, H7N7 and defined an HA domain which may modulate interaction with receptor. We also found that about one third of H5N1 viruses which are isolated during the 2006/07 influenza outbreak in Egypt possibly evolve towards receptor usage similar to that of seasonal H1N1. Conclusion: The presented results may help to better understand the interaction of influenza virus with its receptor(s) and to identify new therapeutic targets for drug development. T2 - BMC Structural Biology T1 - Characterization of conserved properties of hemagglutinin of H5N1 and human influenza viruses: possible consequences for therapy and infection control VL - 9 DO - 10.1186/1472-6807-9-21 ER -
@article{ author = "Veljković, Veljko and Veljković, Nevena V. and Muller, Claude P. and Mueller, Sybille and Glišić, Sanja and Perović, Vladimir R. and Koehler, Heinz", year = "2009", abstract = "Background: Epidemics caused by highly pathogenic avian influenza virus (HPAIV) are a continuing threat to human health and to the worlds economy. The development of approaches, which help to understand the significance of structural changes resulting from the alarming mutational propensity for human-to-human transmission of HPAIV, is of particularly interest. Here we compare informational and structural properties of the hemagglutinin (HA) of H5N1 virus and human influenza virus subtypes, which are important for the receptor/virus interaction. Results: Presented results revealed that HA proteins encode highly conserved information that differ between influenza virus subtypes H5N1, H1N1, H3N2, H7N7 and defined an HA domain which may modulate interaction with receptor. We also found that about one third of H5N1 viruses which are isolated during the 2006/07 influenza outbreak in Egypt possibly evolve towards receptor usage similar to that of seasonal H1N1. Conclusion: The presented results may help to better understand the interaction of influenza virus with its receptor(s) and to identify new therapeutic targets for drug development.", journal = "BMC Structural Biology", title = "Characterization of conserved properties of hemagglutinin of H5N1 and human influenza viruses: possible consequences for therapy and infection control", volume = "9", doi = "10.1186/1472-6807-9-21" }
Veljković, V., Veljković, N. V., Muller, C. P., Mueller, S., Glišić, S., Perović, V. R.,& Koehler, H.. (2009). Characterization of conserved properties of hemagglutinin of H5N1 and human influenza viruses: possible consequences for therapy and infection control. in BMC Structural Biology, 9. https://doi.org/10.1186/1472-6807-9-21
Veljković V, Veljković NV, Muller CP, Mueller S, Glišić S, Perović VR, Koehler H. Characterization of conserved properties of hemagglutinin of H5N1 and human influenza viruses: possible consequences for therapy and infection control. in BMC Structural Biology. 2009;9. doi:10.1186/1472-6807-9-21 .
Veljković, Veljko, Veljković, Nevena V., Muller, Claude P., Mueller, Sybille, Glišić, Sanja, Perović, Vladimir R., Koehler, Heinz, "Characterization of conserved properties of hemagglutinin of H5N1 and human influenza viruses: possible consequences for therapy and infection control" in BMC Structural Biology, 9 (2009), https://doi.org/10.1186/1472-6807-9-21 . .