Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA Study
2009
Аутори
Sokka, TuulikkiToloza, Sergio
Cutolo, Maurizio
Kautiainen, Hannu
Makinen, Heidi
Gogus, Feride
Skakic, Vlado
Badsha, Humeira
Peets, Tonu
Baranauskaite, Asta
Geher, Pal
Ujfalussy, Ilona
Skopouli, Fotini N.
Mavrommati, Maria
Alten, Rieke
Pohl, Christof
Sibilia, Jean
Stancati, Andrea
Salaffi, Fausto
Romanowski, Wojciech
Zarowny-Wierzbinska, Danuta
Henrohn, Dan
Bresnihan, Barry
Minnock, Patricia
Knudsen, Lene Surland
Jacobs, Johannes W. G.
Calvo-Alen, Jaime
Lazovskis, Juris
Castelar Pinheiro, Geraldo da Rocha
Karateev, Dmitry
Andersone, Daina
Rexhepi, Sylejman
Yazici, Yusuf
Pincus, Theodore
QUEST-RA Grp
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Приказ свих података о документуАпстракт
Introduction Gender as a predictor of outcomes of rheumatoid arthritis (RA) has evoked considerable interest over the decades. Historically, there is no consensus whether RA is worse in females or males. Recent reports suggest that females are less likely than males to achieve remission. Therefore, we aimed to study possible associations of gender and disease activity, disease characteristics, and treatments of RA in a large multinational cross-sectional cohort of patients with RA called Quantitative Standard Monitoring of Patients with RA (QUEST-RA). Methods The cohort includes clinical and questionnaire data from patients who were seen in usual care, including 6,004 patients at 70 sites in 25 countries as of April 2008. Gender differences were analyzed for American College of Rheumatology Core Data Set measures of disease activity, DAS28 (disease activity score using 28 joint counts), fatigue, the presence of rheumatoid factor, nodules and erosions, and the current use of prednisone,... methotrexate, and biologic agents. Results Women had poorer scores than men in all Core Data Set measures. The mean values for females and males were swollen joint count-28 (SJC28) of 4.5 versus 3.8, tender joint count-28 of 6.9 versus 5.4, erythrocyte sedimentation rate of 30 versus 26, Health Assessment Questionnaire of 1.1 versus 0.8, visual analog scales for physician global estimate of 3.0 versus 2.5, pain of 4.3 versus 3.6, patient global status of 4.2 versus 3.7, DAS28 of 4.3 versus 3.8, and fatigue of 4.6 versus 3.7 (P LT 0.001). However, effect sizes were small-medium and smallest (0.13) for SJC28. Among patients who had no or minimal disease activity (0 to 1) on SJC28, women had statistically significantly higher mean values compared with men in all other disease activity measures (P LT 0.001) and met DAS28 remission less often than men. Rheumatoid factor was equally prevalent among genders. Men had nodules more often than women. Women had erosions more often than men, but the statistical significance was marginal. Similar proportions of females and males were taking different therapies. Conclusions In this large multinational cohort, RA disease activity measures appear to be worse in women than in men. However, most of the gender differences in RA disease activity may originate from the measures of disease activity rather than from RA disease activity itself.
Извор:
Arthritis Research and Therapy, 2009, 11, 1Финансирање / пројекти:
- Abbott Laboratories (Abbott Park, IL, USA)
DOI: 10.1186/ar2591
ISSN: 1478-6354; 1478-6362
PubMed: 19144159
WoS: 000264563000030
Scopus: 2-s2.0-60549107506
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Институција/група
VinčaTY - JOUR AU - Sokka, Tuulikki AU - Toloza, Sergio AU - Cutolo, Maurizio AU - Kautiainen, Hannu AU - Makinen, Heidi AU - Gogus, Feride AU - Skakic, Vlado AU - Badsha, Humeira AU - Peets, Tonu AU - Baranauskaite, Asta AU - Geher, Pal AU - Ujfalussy, Ilona AU - Skopouli, Fotini N. AU - Mavrommati, Maria AU - Alten, Rieke AU - Pohl, Christof AU - Sibilia, Jean AU - Stancati, Andrea AU - Salaffi, Fausto AU - Romanowski, Wojciech AU - Zarowny-Wierzbinska, Danuta AU - Henrohn, Dan AU - Bresnihan, Barry AU - Minnock, Patricia AU - Knudsen, Lene Surland AU - Jacobs, Johannes W. G. AU - Calvo-Alen, Jaime AU - Lazovskis, Juris AU - Castelar Pinheiro, Geraldo da Rocha AU - Karateev, Dmitry AU - Andersone, Daina AU - Rexhepi, Sylejman AU - Yazici, Yusuf AU - Pincus, Theodore AU - QUEST-RA Grp PY - 2009 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3660 AB - Introduction Gender as a predictor of outcomes of rheumatoid arthritis (RA) has evoked considerable interest over the decades. Historically, there is no consensus whether RA is worse in females or males. Recent reports suggest that females are less likely than males to achieve remission. Therefore, we aimed to study possible associations of gender and disease activity, disease characteristics, and treatments of RA in a large multinational cross-sectional cohort of patients with RA called Quantitative Standard Monitoring of Patients with RA (QUEST-RA). Methods The cohort includes clinical and questionnaire data from patients who were seen in usual care, including 6,004 patients at 70 sites in 25 countries as of April 2008. Gender differences were analyzed for American College of Rheumatology Core Data Set measures of disease activity, DAS28 (disease activity score using 28 joint counts), fatigue, the presence of rheumatoid factor, nodules and erosions, and the current use of prednisone, methotrexate, and biologic agents. Results Women had poorer scores than men in all Core Data Set measures. The mean values for females and males were swollen joint count-28 (SJC28) of 4.5 versus 3.8, tender joint count-28 of 6.9 versus 5.4, erythrocyte sedimentation rate of 30 versus 26, Health Assessment Questionnaire of 1.1 versus 0.8, visual analog scales for physician global estimate of 3.0 versus 2.5, pain of 4.3 versus 3.6, patient global status of 4.2 versus 3.7, DAS28 of 4.3 versus 3.8, and fatigue of 4.6 versus 3.7 (P LT 0.001). However, effect sizes were small-medium and smallest (0.13) for SJC28. Among patients who had no or minimal disease activity (0 to 1) on SJC28, women had statistically significantly higher mean values compared with men in all other disease activity measures (P LT 0.001) and met DAS28 remission less often than men. Rheumatoid factor was equally prevalent among genders. Men had nodules more often than women. Women had erosions more often than men, but the statistical significance was marginal. Similar proportions of females and males were taking different therapies. Conclusions In this large multinational cohort, RA disease activity measures appear to be worse in women than in men. However, most of the gender differences in RA disease activity may originate from the measures of disease activity rather than from RA disease activity itself. T2 - Arthritis Research and Therapy T1 - Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA Study VL - 11 IS - 1 DO - 10.1186/ar2591 ER -
@article{ author = "Sokka, Tuulikki and Toloza, Sergio and Cutolo, Maurizio and Kautiainen, Hannu and Makinen, Heidi and Gogus, Feride and Skakic, Vlado and Badsha, Humeira and Peets, Tonu and Baranauskaite, Asta and Geher, Pal and Ujfalussy, Ilona and Skopouli, Fotini N. and Mavrommati, Maria and Alten, Rieke and Pohl, Christof and Sibilia, Jean and Stancati, Andrea and Salaffi, Fausto and Romanowski, Wojciech and Zarowny-Wierzbinska, Danuta and Henrohn, Dan and Bresnihan, Barry and Minnock, Patricia and Knudsen, Lene Surland and Jacobs, Johannes W. G. and Calvo-Alen, Jaime and Lazovskis, Juris and Castelar Pinheiro, Geraldo da Rocha and Karateev, Dmitry and Andersone, Daina and Rexhepi, Sylejman and Yazici, Yusuf and Pincus, Theodore and QUEST-RA Grp", year = "2009", abstract = "Introduction Gender as a predictor of outcomes of rheumatoid arthritis (RA) has evoked considerable interest over the decades. Historically, there is no consensus whether RA is worse in females or males. Recent reports suggest that females are less likely than males to achieve remission. Therefore, we aimed to study possible associations of gender and disease activity, disease characteristics, and treatments of RA in a large multinational cross-sectional cohort of patients with RA called Quantitative Standard Monitoring of Patients with RA (QUEST-RA). Methods The cohort includes clinical and questionnaire data from patients who were seen in usual care, including 6,004 patients at 70 sites in 25 countries as of April 2008. Gender differences were analyzed for American College of Rheumatology Core Data Set measures of disease activity, DAS28 (disease activity score using 28 joint counts), fatigue, the presence of rheumatoid factor, nodules and erosions, and the current use of prednisone, methotrexate, and biologic agents. Results Women had poorer scores than men in all Core Data Set measures. The mean values for females and males were swollen joint count-28 (SJC28) of 4.5 versus 3.8, tender joint count-28 of 6.9 versus 5.4, erythrocyte sedimentation rate of 30 versus 26, Health Assessment Questionnaire of 1.1 versus 0.8, visual analog scales for physician global estimate of 3.0 versus 2.5, pain of 4.3 versus 3.6, patient global status of 4.2 versus 3.7, DAS28 of 4.3 versus 3.8, and fatigue of 4.6 versus 3.7 (P LT 0.001). However, effect sizes were small-medium and smallest (0.13) for SJC28. Among patients who had no or minimal disease activity (0 to 1) on SJC28, women had statistically significantly higher mean values compared with men in all other disease activity measures (P LT 0.001) and met DAS28 remission less often than men. Rheumatoid factor was equally prevalent among genders. Men had nodules more often than women. Women had erosions more often than men, but the statistical significance was marginal. Similar proportions of females and males were taking different therapies. Conclusions In this large multinational cohort, RA disease activity measures appear to be worse in women than in men. However, most of the gender differences in RA disease activity may originate from the measures of disease activity rather than from RA disease activity itself.", journal = "Arthritis Research and Therapy", title = "Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA Study", volume = "11", number = "1", doi = "10.1186/ar2591" }
Sokka, T., Toloza, S., Cutolo, M., Kautiainen, H., Makinen, H., Gogus, F., Skakic, V., Badsha, H., Peets, T., Baranauskaite, A., Geher, P., Ujfalussy, I., Skopouli, F. N., Mavrommati, M., Alten, R., Pohl, C., Sibilia, J., Stancati, A., Salaffi, F., Romanowski, W., Zarowny-Wierzbinska, D., Henrohn, D., Bresnihan, B., Minnock, P., Knudsen, L. S., Jacobs, J. W. G., Calvo-Alen, J., Lazovskis, J., Castelar Pinheiro, G. d. R., Karateev, D., Andersone, D., Rexhepi, S., Yazici, Y., Pincus, T.,& QUEST-RA Grp. (2009). Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA Study. in Arthritis Research and Therapy, 11(1). https://doi.org/10.1186/ar2591
Sokka T, Toloza S, Cutolo M, Kautiainen H, Makinen H, Gogus F, Skakic V, Badsha H, Peets T, Baranauskaite A, Geher P, Ujfalussy I, Skopouli FN, Mavrommati M, Alten R, Pohl C, Sibilia J, Stancati A, Salaffi F, Romanowski W, Zarowny-Wierzbinska D, Henrohn D, Bresnihan B, Minnock P, Knudsen LS, Jacobs JWG, Calvo-Alen J, Lazovskis J, Castelar Pinheiro GDR, Karateev D, Andersone D, Rexhepi S, Yazici Y, Pincus T, QUEST-RA Grp. Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA Study. in Arthritis Research and Therapy. 2009;11(1). doi:10.1186/ar2591 .
Sokka, Tuulikki, Toloza, Sergio, Cutolo, Maurizio, Kautiainen, Hannu, Makinen, Heidi, Gogus, Feride, Skakic, Vlado, Badsha, Humeira, Peets, Tonu, Baranauskaite, Asta, Geher, Pal, Ujfalussy, Ilona, Skopouli, Fotini N., Mavrommati, Maria, Alten, Rieke, Pohl, Christof, Sibilia, Jean, Stancati, Andrea, Salaffi, Fausto, Romanowski, Wojciech, Zarowny-Wierzbinska, Danuta, Henrohn, Dan, Bresnihan, Barry, Minnock, Patricia, Knudsen, Lene Surland, Jacobs, Johannes W. G., Calvo-Alen, Jaime, Lazovskis, Juris, Castelar Pinheiro, Geraldo da Rocha, Karateev, Dmitry, Andersone, Daina, Rexhepi, Sylejman, Yazici, Yusuf, Pincus, Theodore, QUEST-RA Grp, "Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA Study" in Arthritis Research and Therapy, 11, no. 1 (2009), https://doi.org/10.1186/ar2591 . .