High efficiency production and purification of (86)Y based on electrochemical separation
Нема приказа
Аутори
Lukić, Dragoljub M.Tamburella, Claire
Buchegger, Franz
Beyer, Gerd-Juergen
Čomor, Jožef J.
Seimbille, Yann
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт
As an intermediate half-life positron emitter (86)Y is an attractive radioisotope for positron emission tomography (PET) studies, particularly for patient specific dosimetry planning of (90)Y-based radiotherapy procedures. It can be conveniently produced by a small-sized cyclotron via the (86)Sr(p,n)(86)Y nuclear reaction. The optimization of the electrochemical separation of (86)Y from the target material and its purification was done by modeling the whole production cycle using (90)Y. The radionuclide was isolated using four electrodes in two electrolytic steps. In the first step two Pt plate anodes and a Pt Winkler cathode were used and the electro-deposition yield was determined in constant current mode of operation. In addition, the influence of pH on the efficiency of this first step was investigated. The second electrolysis, with Winkler electrode as anode and a Pt wire as cathode, was also performed in constant current mode of operation. The kinetics of recovery of the deposite...d activity on the Pt wire was investigated in acidic solutions. The optimized electrochemical method was then applied for (86)Y separation and purification. This modified procedure was proved to be faster and simpler than the previously proposed electrochemical techniques and is more convenient for automation of the routine production of (86)Y. (C) 2008 Elsevier Ltd. All rights reserved.
Кључне речи:
(86)Y / Electrochemical separation / Production of radionuclides / Radioimmunotheraphy / PETИзвор:
Applied Radiation and Isotopes, 2009, 67, 4, 523-529Финансирање / пројекти:
- Geneva Cancer League [313], Research and Development Found of Geneva University Hospital, Ministry of Science of Serbia
DOI: 10.1016/j.apradiso.2008.12.008
ISSN: 0969-8043
PubMed: 19181533
WoS: 000264305500005
Scopus: 2-s2.0-60149112275
Колекције
Институција/група
VinčaTY - JOUR AU - Lukić, Dragoljub M. AU - Tamburella, Claire AU - Buchegger, Franz AU - Beyer, Gerd-Juergen AU - Čomor, Jožef J. AU - Seimbille, Yann PY - 2009 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3655 AB - As an intermediate half-life positron emitter (86)Y is an attractive radioisotope for positron emission tomography (PET) studies, particularly for patient specific dosimetry planning of (90)Y-based radiotherapy procedures. It can be conveniently produced by a small-sized cyclotron via the (86)Sr(p,n)(86)Y nuclear reaction. The optimization of the electrochemical separation of (86)Y from the target material and its purification was done by modeling the whole production cycle using (90)Y. The radionuclide was isolated using four electrodes in two electrolytic steps. In the first step two Pt plate anodes and a Pt Winkler cathode were used and the electro-deposition yield was determined in constant current mode of operation. In addition, the influence of pH on the efficiency of this first step was investigated. The second electrolysis, with Winkler electrode as anode and a Pt wire as cathode, was also performed in constant current mode of operation. The kinetics of recovery of the deposited activity on the Pt wire was investigated in acidic solutions. The optimized electrochemical method was then applied for (86)Y separation and purification. This modified procedure was proved to be faster and simpler than the previously proposed electrochemical techniques and is more convenient for automation of the routine production of (86)Y. (C) 2008 Elsevier Ltd. All rights reserved. T2 - Applied Radiation and Isotopes T1 - High efficiency production and purification of (86)Y based on electrochemical separation VL - 67 IS - 4 SP - 523 EP - 529 DO - 10.1016/j.apradiso.2008.12.008 ER -
@article{ author = "Lukić, Dragoljub M. and Tamburella, Claire and Buchegger, Franz and Beyer, Gerd-Juergen and Čomor, Jožef J. and Seimbille, Yann", year = "2009", abstract = "As an intermediate half-life positron emitter (86)Y is an attractive radioisotope for positron emission tomography (PET) studies, particularly for patient specific dosimetry planning of (90)Y-based radiotherapy procedures. It can be conveniently produced by a small-sized cyclotron via the (86)Sr(p,n)(86)Y nuclear reaction. The optimization of the electrochemical separation of (86)Y from the target material and its purification was done by modeling the whole production cycle using (90)Y. The radionuclide was isolated using four electrodes in two electrolytic steps. In the first step two Pt plate anodes and a Pt Winkler cathode were used and the electro-deposition yield was determined in constant current mode of operation. In addition, the influence of pH on the efficiency of this first step was investigated. The second electrolysis, with Winkler electrode as anode and a Pt wire as cathode, was also performed in constant current mode of operation. The kinetics of recovery of the deposited activity on the Pt wire was investigated in acidic solutions. The optimized electrochemical method was then applied for (86)Y separation and purification. This modified procedure was proved to be faster and simpler than the previously proposed electrochemical techniques and is more convenient for automation of the routine production of (86)Y. (C) 2008 Elsevier Ltd. All rights reserved.", journal = "Applied Radiation and Isotopes", title = "High efficiency production and purification of (86)Y based on electrochemical separation", volume = "67", number = "4", pages = "523-529", doi = "10.1016/j.apradiso.2008.12.008" }
Lukić, D. M., Tamburella, C., Buchegger, F., Beyer, G., Čomor, J. J.,& Seimbille, Y.. (2009). High efficiency production and purification of (86)Y based on electrochemical separation. in Applied Radiation and Isotopes, 67(4), 523-529. https://doi.org/10.1016/j.apradiso.2008.12.008
Lukić DM, Tamburella C, Buchegger F, Beyer G, Čomor JJ, Seimbille Y. High efficiency production and purification of (86)Y based on electrochemical separation. in Applied Radiation and Isotopes. 2009;67(4):523-529. doi:10.1016/j.apradiso.2008.12.008 .
Lukić, Dragoljub M., Tamburella, Claire, Buchegger, Franz, Beyer, Gerd-Juergen, Čomor, Jožef J., Seimbille, Yann, "High efficiency production and purification of (86)Y based on electrochemical separation" in Applied Radiation and Isotopes, 67, no. 4 (2009):523-529, https://doi.org/10.1016/j.apradiso.2008.12.008 . .