Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages
Abstract
Oxidative stress is considered to be implicated in the pathophysiology of breast cancers. In this study we investigated the level of oxidative stress and antioxidant (AO) status in the blood of breast cancer patients of different ages. The level of lipid hydroperoxides (LP) was measured in blood plasma and the activities of copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) enzymes, as well as the level of total glutathione (GSH) and CuZnSOD protein were measured in blood cells of breast cancer patients and age-matched healthy subjects. Our results showed that breast carcinoma is related to increase of lipid peroxidation in plasma with concomitant decrease of AO defense capacity in blood cells, which becomes more pronounced during aging of the patients. Suppression of CuZnSOD activity related to breast cancer is most likely caused by decreased de novo synthesis of this enzyme. Similar patterns of suppression in CuZn...SOD and CAT activities related to aging were recorded both in controls and patients. Age-related decrease in CuZnSOD activity seems not to be caused by altered protein levels of this enzyme. Suppression of AO enzymes associated with breast cancer and aging is most likely the cause of increased levels of reactive oxygen species (ROS). Our results indicate significant role of oxidative-induced injury in the breast carcinogenesis, particularly during the later stages of aging. Overall, Our data Support the importance of endogenous AOs in the etiology of breast cancer across all levels of predicted risk. Copyright (C) 2008 John Wiley and Sons, Ltd.
Keywords:
lipid peroxidation / antioxidants / breast cancer / agingSource:
Cell Biochemistry and Function, 2008, 26, 6, 723-730Funding / projects:
- Ministry of Science and Environmental Protection of the Republic of Serbia [143035 B, 143044 B]
DOI: 10.1002/cbf.1499
ISSN: 0263-6484; 1099-0844
PubMed: 18636415
WoS: 000259290800010
Scopus: 2-s2.0-52649111206
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Institution/Community
VinčaTY - JOUR AU - Kasapović, Jelena AU - Pejić, Snežana AU - Todorović, Ana AU - Stojiljković, Vesna AU - Pajović, Snežana B. PY - 2008 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3524 AB - Oxidative stress is considered to be implicated in the pathophysiology of breast cancers. In this study we investigated the level of oxidative stress and antioxidant (AO) status in the blood of breast cancer patients of different ages. The level of lipid hydroperoxides (LP) was measured in blood plasma and the activities of copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) enzymes, as well as the level of total glutathione (GSH) and CuZnSOD protein were measured in blood cells of breast cancer patients and age-matched healthy subjects. Our results showed that breast carcinoma is related to increase of lipid peroxidation in plasma with concomitant decrease of AO defense capacity in blood cells, which becomes more pronounced during aging of the patients. Suppression of CuZnSOD activity related to breast cancer is most likely caused by decreased de novo synthesis of this enzyme. Similar patterns of suppression in CuZnSOD and CAT activities related to aging were recorded both in controls and patients. Age-related decrease in CuZnSOD activity seems not to be caused by altered protein levels of this enzyme. Suppression of AO enzymes associated with breast cancer and aging is most likely the cause of increased levels of reactive oxygen species (ROS). Our results indicate significant role of oxidative-induced injury in the breast carcinogenesis, particularly during the later stages of aging. Overall, Our data Support the importance of endogenous AOs in the etiology of breast cancer across all levels of predicted risk. Copyright (C) 2008 John Wiley and Sons, Ltd. T2 - Cell Biochemistry and Function T1 - Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages VL - 26 IS - 6 SP - 723 EP - 730 DO - 10.1002/cbf.1499 ER -
@article{ author = "Kasapović, Jelena and Pejić, Snežana and Todorović, Ana and Stojiljković, Vesna and Pajović, Snežana B.", year = "2008", abstract = "Oxidative stress is considered to be implicated in the pathophysiology of breast cancers. In this study we investigated the level of oxidative stress and antioxidant (AO) status in the blood of breast cancer patients of different ages. The level of lipid hydroperoxides (LP) was measured in blood plasma and the activities of copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) enzymes, as well as the level of total glutathione (GSH) and CuZnSOD protein were measured in blood cells of breast cancer patients and age-matched healthy subjects. Our results showed that breast carcinoma is related to increase of lipid peroxidation in plasma with concomitant decrease of AO defense capacity in blood cells, which becomes more pronounced during aging of the patients. Suppression of CuZnSOD activity related to breast cancer is most likely caused by decreased de novo synthesis of this enzyme. Similar patterns of suppression in CuZnSOD and CAT activities related to aging were recorded both in controls and patients. Age-related decrease in CuZnSOD activity seems not to be caused by altered protein levels of this enzyme. Suppression of AO enzymes associated with breast cancer and aging is most likely the cause of increased levels of reactive oxygen species (ROS). Our results indicate significant role of oxidative-induced injury in the breast carcinogenesis, particularly during the later stages of aging. Overall, Our data Support the importance of endogenous AOs in the etiology of breast cancer across all levels of predicted risk. Copyright (C) 2008 John Wiley and Sons, Ltd.", journal = "Cell Biochemistry and Function", title = "Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages", volume = "26", number = "6", pages = "723-730", doi = "10.1002/cbf.1499" }
Kasapović, J., Pejić, S., Todorović, A., Stojiljković, V.,& Pajović, S. B.. (2008). Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages. in Cell Biochemistry and Function, 26(6), 723-730. https://doi.org/10.1002/cbf.1499
Kasapović J, Pejić S, Todorović A, Stojiljković V, Pajović SB. Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages. in Cell Biochemistry and Function. 2008;26(6):723-730. doi:10.1002/cbf.1499 .
Kasapović, Jelena, Pejić, Snežana, Todorović, Ana, Stojiljković, Vesna, Pajović, Snežana B., "Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages" in Cell Biochemistry and Function, 26, no. 6 (2008):723-730, https://doi.org/10.1002/cbf.1499 . .