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Biomedical potential of the reactive oxygen species generation and quenching by fullerenes (C-60)
dc.creator | Marković, Zoran M. | |
dc.creator | Trajković, Vladimir S. | |
dc.date.accessioned | 2018-03-01T20:30:34Z | |
dc.date.available | 2018-03-01T20:30:34Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0142-9612 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/3504 | |
dc.description.abstract | Fullerene (C-60), a third carbon allotrope, is a classical engineered material with the potential application in biomedicine. One of the biologically most relevant features of C-60 is the ability to quench various free radicals, behaving as a free radical sponge. Conversely, photosensitization of C-60 leads to its transition to a long-lived triplet excited state and the subsequent energy or electron transfer to molecular oxygen, yielding highly reactive singlet oxygen (O-1(2)) or superoxide anion (O-2(center dot-)), respectively. These reactive oxygen species (ROS) react with a wide range of biological targets and are known to be involved in both cellular signaling and cell damage. Therefore, the dual property of fullerenes to either quench or generate cell-damaging ROS could be potentially exploited for their development as cytoprotective or cytotoxic anticancer/antimicrobial agents. However, the attempts to that effect have been hampered by the extremely low water solubility of C-60, and by the fact that solubilization procedures profoundly influence the ROS-generating/quenching properties of C-60, either through chemical modification or through formation of complex nanoscale particles with different photophysical properties. We here analyze the mechanisms and biological consequences of ROS generation/quenching by C-60, focusing on the influence that different physico-chemical alterations exert on its ROS-related biological behavior. (c) 2008 Elsevier Ltd. All rights reserved. | en |
dc.rights | restrictedAccess | en |
dc.source | Biomaterials | en |
dc.subject | carbon | en |
dc.subject | nanoparticle | en |
dc.subject | antioxidant | en |
dc.subject | cytotoxicity | en |
dc.title | Biomedical potential of the reactive oxygen species generation and quenching by fullerenes (C-60) | en |
dc.type | review | en |
dcterms.abstract | Трајковиц, Владимир; Марковић Зоран; | |
dc.citation.volume | 29 | |
dc.citation.issue | 26 | |
dc.citation.spage | 3561 | |
dc.citation.epage | 3573 | |
dc.identifier.wos | 000258357000009 | |
dc.identifier.doi | 10.1016/j.biomaterials.2008.05.005 | |
dc.citation.rank | M21a | |
dc.identifier.pmid | 18534675 | |
dc.identifier.scopus | 2-s2.0-46249084082 |
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