Biomedical potential of the reactive oxygen species generation and quenching by fullerenes (C-60)
Abstract
Fullerene (C-60), a third carbon allotrope, is a classical engineered material with the potential application in biomedicine. One of the biologically most relevant features of C-60 is the ability to quench various free radicals, behaving as a free radical sponge. Conversely, photosensitization of C-60 leads to its transition to a long-lived triplet excited state and the subsequent energy or electron transfer to molecular oxygen, yielding highly reactive singlet oxygen (O-1(2)) or superoxide anion (O-2(center dot-)), respectively. These reactive oxygen species (ROS) react with a wide range of biological targets and are known to be involved in both cellular signaling and cell damage. Therefore, the dual property of fullerenes to either quench or generate cell-damaging ROS could be potentially exploited for their development as cytoprotective or cytotoxic anticancer/antimicrobial agents. However, the attempts to that effect have been hampered by the extremely low water solubility of C-60,... and by the fact that solubilization procedures profoundly influence the ROS-generating/quenching properties of C-60, either through chemical modification or through formation of complex nanoscale particles with different photophysical properties. We here analyze the mechanisms and biological consequences of ROS generation/quenching by C-60, focusing on the influence that different physico-chemical alterations exert on its ROS-related biological behavior. (c) 2008 Elsevier Ltd. All rights reserved.
Keywords:
carbon / nanoparticle / antioxidant / cytotoxicitySource:
Biomaterials, 2008, 29, 26, 3561-3573
DOI: 10.1016/j.biomaterials.2008.05.005
ISSN: 0142-9612
PubMed: 18534675
WoS: 000258357000009
Scopus: 2-s2.0-46249084082
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Institution/Community
VinčaTY - JOUR AU - Marković, Zoran M. AU - Trajković, Vladimir S. PY - 2008 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3504 AB - Fullerene (C-60), a third carbon allotrope, is a classical engineered material with the potential application in biomedicine. One of the biologically most relevant features of C-60 is the ability to quench various free radicals, behaving as a free radical sponge. Conversely, photosensitization of C-60 leads to its transition to a long-lived triplet excited state and the subsequent energy or electron transfer to molecular oxygen, yielding highly reactive singlet oxygen (O-1(2)) or superoxide anion (O-2(center dot-)), respectively. These reactive oxygen species (ROS) react with a wide range of biological targets and are known to be involved in both cellular signaling and cell damage. Therefore, the dual property of fullerenes to either quench or generate cell-damaging ROS could be potentially exploited for their development as cytoprotective or cytotoxic anticancer/antimicrobial agents. However, the attempts to that effect have been hampered by the extremely low water solubility of C-60, and by the fact that solubilization procedures profoundly influence the ROS-generating/quenching properties of C-60, either through chemical modification or through formation of complex nanoscale particles with different photophysical properties. We here analyze the mechanisms and biological consequences of ROS generation/quenching by C-60, focusing on the influence that different physico-chemical alterations exert on its ROS-related biological behavior. (c) 2008 Elsevier Ltd. All rights reserved. T2 - Biomaterials T1 - Biomedical potential of the reactive oxygen species generation and quenching by fullerenes (C-60) VL - 29 IS - 26 SP - 3561 EP - 3573 DO - 10.1016/j.biomaterials.2008.05.005 ER -
@article{ author = "Marković, Zoran M. and Trajković, Vladimir S.", year = "2008", abstract = "Fullerene (C-60), a third carbon allotrope, is a classical engineered material with the potential application in biomedicine. One of the biologically most relevant features of C-60 is the ability to quench various free radicals, behaving as a free radical sponge. Conversely, photosensitization of C-60 leads to its transition to a long-lived triplet excited state and the subsequent energy or electron transfer to molecular oxygen, yielding highly reactive singlet oxygen (O-1(2)) or superoxide anion (O-2(center dot-)), respectively. These reactive oxygen species (ROS) react with a wide range of biological targets and are known to be involved in both cellular signaling and cell damage. Therefore, the dual property of fullerenes to either quench or generate cell-damaging ROS could be potentially exploited for their development as cytoprotective or cytotoxic anticancer/antimicrobial agents. However, the attempts to that effect have been hampered by the extremely low water solubility of C-60, and by the fact that solubilization procedures profoundly influence the ROS-generating/quenching properties of C-60, either through chemical modification or through formation of complex nanoscale particles with different photophysical properties. We here analyze the mechanisms and biological consequences of ROS generation/quenching by C-60, focusing on the influence that different physico-chemical alterations exert on its ROS-related biological behavior. (c) 2008 Elsevier Ltd. All rights reserved.", journal = "Biomaterials", title = "Biomedical potential of the reactive oxygen species generation and quenching by fullerenes (C-60)", volume = "29", number = "26", pages = "3561-3573", doi = "10.1016/j.biomaterials.2008.05.005" }
Marković, Z. M.,& Trajković, V. S.. (2008). Biomedical potential of the reactive oxygen species generation and quenching by fullerenes (C-60). in Biomaterials, 29(26), 3561-3573. https://doi.org/10.1016/j.biomaterials.2008.05.005
Marković ZM, Trajković VS. Biomedical potential of the reactive oxygen species generation and quenching by fullerenes (C-60). in Biomaterials. 2008;29(26):3561-3573. doi:10.1016/j.biomaterials.2008.05.005 .
Marković, Zoran M., Trajković, Vladimir S., "Biomedical potential of the reactive oxygen species generation and quenching by fullerenes (C-60)" in Biomaterials, 29, no. 26 (2008):3561-3573, https://doi.org/10.1016/j.biomaterials.2008.05.005 . .