Different behavioral effects of maprotiline and fluxilan in rats
Abstract
Serotonin and noradrenaline are involved in the mechanisms of action of most antidepressant drugs. We examined the effects of chronic treatment with maprotiline, a selective inhibitor of noradrenaline reuptake, and fluxilan, a selective inhibitor of serotonin reuptake, on the behavior of unstressed controls and chronic unpredictable mild stress (CUMS) model rats in the forced swim test (FST) and elevated plus maze test. Both selective reuptake inhibitors resulted in a significant reduction of time spent in immobility. Climbing was significantly increased in maprotiline- and swimming was exclusively elicited in the fluxilan-treated unstressed control and CUMS rats. Maprotiline-treated animals displayed decreased anxiety and fluxilan-treated rats enhanced anxiety. The obtained results suggest that central noradrenergic and serotonergic systems might be affected differently during FST. The results also demonstrate that the anxiogenic effects of chronic fluxilan treatment are similar to th...ose reported by many other studies. These differences observed for the effects of fluxilan in relation to those reported for maprotiline and probably due to the different pharmacological profiles of these drugs.
Keywords:
behavior / rats / antidepressants / monoamine reuptake inhibitorsSource:
Archives of Biological Sciences, 2008, 60, 1, 33-39Funding / projects:
- Signalni putevi delovanja steroidnih hormona i uticaj endogenih i egzogenih faktora na modulaciju procesa u ćelijama sisara (RS-MESTD-MPN2006-2010-143044)
DOI: 10.2298/ABS0801033S
ISSN: 0354-4664
WoS: 000254813700006
Scopus: 2-s2.0-53549090423
Collections
Institution/Community
VinčaTY - JOUR AU - Spasojević, Nataša AU - Gavrilović, Ljubica AU - Dronjak, Slađana PY - 2008 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3407 AB - Serotonin and noradrenaline are involved in the mechanisms of action of most antidepressant drugs. We examined the effects of chronic treatment with maprotiline, a selective inhibitor of noradrenaline reuptake, and fluxilan, a selective inhibitor of serotonin reuptake, on the behavior of unstressed controls and chronic unpredictable mild stress (CUMS) model rats in the forced swim test (FST) and elevated plus maze test. Both selective reuptake inhibitors resulted in a significant reduction of time spent in immobility. Climbing was significantly increased in maprotiline- and swimming was exclusively elicited in the fluxilan-treated unstressed control and CUMS rats. Maprotiline-treated animals displayed decreased anxiety and fluxilan-treated rats enhanced anxiety. The obtained results suggest that central noradrenergic and serotonergic systems might be affected differently during FST. The results also demonstrate that the anxiogenic effects of chronic fluxilan treatment are similar to those reported by many other studies. These differences observed for the effects of fluxilan in relation to those reported for maprotiline and probably due to the different pharmacological profiles of these drugs. T2 - Archives of Biological Sciences T1 - Different behavioral effects of maprotiline and fluxilan in rats VL - 60 IS - 1 SP - 33 EP - 39 DO - 10.2298/ABS0801033S ER -
@article{ author = "Spasojević, Nataša and Gavrilović, Ljubica and Dronjak, Slađana", year = "2008", abstract = "Serotonin and noradrenaline are involved in the mechanisms of action of most antidepressant drugs. We examined the effects of chronic treatment with maprotiline, a selective inhibitor of noradrenaline reuptake, and fluxilan, a selective inhibitor of serotonin reuptake, on the behavior of unstressed controls and chronic unpredictable mild stress (CUMS) model rats in the forced swim test (FST) and elevated plus maze test. Both selective reuptake inhibitors resulted in a significant reduction of time spent in immobility. Climbing was significantly increased in maprotiline- and swimming was exclusively elicited in the fluxilan-treated unstressed control and CUMS rats. Maprotiline-treated animals displayed decreased anxiety and fluxilan-treated rats enhanced anxiety. The obtained results suggest that central noradrenergic and serotonergic systems might be affected differently during FST. The results also demonstrate that the anxiogenic effects of chronic fluxilan treatment are similar to those reported by many other studies. These differences observed for the effects of fluxilan in relation to those reported for maprotiline and probably due to the different pharmacological profiles of these drugs.", journal = "Archives of Biological Sciences", title = "Different behavioral effects of maprotiline and fluxilan in rats", volume = "60", number = "1", pages = "33-39", doi = "10.2298/ABS0801033S" }
Spasojević, N., Gavrilović, L.,& Dronjak, S.. (2008). Different behavioral effects of maprotiline and fluxilan in rats. in Archives of Biological Sciences, 60(1), 33-39. https://doi.org/10.2298/ABS0801033S
Spasojević N, Gavrilović L, Dronjak S. Different behavioral effects of maprotiline and fluxilan in rats. in Archives of Biological Sciences. 2008;60(1):33-39. doi:10.2298/ABS0801033S .
Spasojević, Nataša, Gavrilović, Ljubica, Dronjak, Slađana, "Different behavioral effects of maprotiline and fluxilan in rats" in Archives of Biological Sciences, 60, no. 1 (2008):33-39, https://doi.org/10.2298/ABS0801033S . .