The mechanism of cell-damaging reactive oxygen generation by colloidal fullerenes
Nema prikaza
Autori
Marković, Zoran M.Todorović-Marković, Biljana
Kleut, Duška
Nikolić, Nadežda S.
Vranješ-Đurić, Sanja
Misirkić, Maja
Vucicevic, Ljubica
Janjetović, Kristina D.
Isaković, Aleksandra J.
Harhaji, Ljubica M.
Babić-Stojić, Branka S.
Dramićanin, Miroslav
Trajković, Vladimir S.
Članak u časopisu
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Because of the ability to induce cell death in certain conditions, the fullerenes (C-60) are potential anticancer and toxic agents. The colloidal suspension of crystalline C-60 (nano-C-60, nC(60)) is extremely toxic, but the mechanisms of its cytotoxicity are not completely understood. By combining experimental analysis and mathematical modelling, we investigate the requirements for the reactive oxygen species (ROS)-mediated cytotoxicity of different nC(60) suspensions, prepared by solvent exchange method in tetrahydrofuran (THF/nC(60)) and ethanol (EtOH/nC(60)), or by extended mixing in water (aqu/nC(60)). With regard to their capacity to generate ROS and cause mitochondrial depolarization followed by necrotic cell death, the nC(60) suspensions are ranked in the following order: THF/nC(60) GT EtOH/nC(60) GT aqu/nC(60). Mathematical modelling of singlet oxygen (O-1(2)) generation indicates that the O-1(2)-quenching power (THF/nC(60) LT EtOH/nC(60) LT aqU/nC(60)) of the solvent intercal...ated in the fullerene crystals determines their ability to produce ROS and cause cell damage. These data could. have important implications for toxicology and biomedical application of colloidal fullerenes. (C) 2007 Elsevier Ltd. All rights reserved.
Ključne reči:
carbon / nanoparticle / cytotoxicity / free radical / modellingIzvor:
Biomaterials, 2007, 28, 36, 5437-5448
DOI: 10.1016/j.biomaterials.2007.09.002
ISSN: 0142-9612
PubMed: 17884160
WoS: 000251359000005
Scopus: 2-s2.0-35348935601
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Marković, Zoran M. AU - Todorović-Marković, Biljana AU - Kleut, Duška AU - Nikolić, Nadežda S. AU - Vranješ-Đurić, Sanja AU - Misirkić, Maja AU - Vucicevic, Ljubica AU - Janjetović, Kristina D. AU - Isaković, Aleksandra J. AU - Harhaji, Ljubica M. AU - Babić-Stojić, Branka S. AU - Dramićanin, Miroslav AU - Trajković, Vladimir S. PY - 2007 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3322 AB - Because of the ability to induce cell death in certain conditions, the fullerenes (C-60) are potential anticancer and toxic agents. The colloidal suspension of crystalline C-60 (nano-C-60, nC(60)) is extremely toxic, but the mechanisms of its cytotoxicity are not completely understood. By combining experimental analysis and mathematical modelling, we investigate the requirements for the reactive oxygen species (ROS)-mediated cytotoxicity of different nC(60) suspensions, prepared by solvent exchange method in tetrahydrofuran (THF/nC(60)) and ethanol (EtOH/nC(60)), or by extended mixing in water (aqu/nC(60)). With regard to their capacity to generate ROS and cause mitochondrial depolarization followed by necrotic cell death, the nC(60) suspensions are ranked in the following order: THF/nC(60) GT EtOH/nC(60) GT aqu/nC(60). Mathematical modelling of singlet oxygen (O-1(2)) generation indicates that the O-1(2)-quenching power (THF/nC(60) LT EtOH/nC(60) LT aqU/nC(60)) of the solvent intercalated in the fullerene crystals determines their ability to produce ROS and cause cell damage. These data could. have important implications for toxicology and biomedical application of colloidal fullerenes. (C) 2007 Elsevier Ltd. All rights reserved. T2 - Biomaterials T1 - The mechanism of cell-damaging reactive oxygen generation by colloidal fullerenes VL - 28 IS - 36 SP - 5437 EP - 5448 DO - 10.1016/j.biomaterials.2007.09.002 ER -
@article{ author = "Marković, Zoran M. and Todorović-Marković, Biljana and Kleut, Duška and Nikolić, Nadežda S. and Vranješ-Đurić, Sanja and Misirkić, Maja and Vucicevic, Ljubica and Janjetović, Kristina D. and Isaković, Aleksandra J. and Harhaji, Ljubica M. and Babić-Stojić, Branka S. and Dramićanin, Miroslav and Trajković, Vladimir S.", year = "2007", abstract = "Because of the ability to induce cell death in certain conditions, the fullerenes (C-60) are potential anticancer and toxic agents. The colloidal suspension of crystalline C-60 (nano-C-60, nC(60)) is extremely toxic, but the mechanisms of its cytotoxicity are not completely understood. By combining experimental analysis and mathematical modelling, we investigate the requirements for the reactive oxygen species (ROS)-mediated cytotoxicity of different nC(60) suspensions, prepared by solvent exchange method in tetrahydrofuran (THF/nC(60)) and ethanol (EtOH/nC(60)), or by extended mixing in water (aqu/nC(60)). With regard to their capacity to generate ROS and cause mitochondrial depolarization followed by necrotic cell death, the nC(60) suspensions are ranked in the following order: THF/nC(60) GT EtOH/nC(60) GT aqu/nC(60). Mathematical modelling of singlet oxygen (O-1(2)) generation indicates that the O-1(2)-quenching power (THF/nC(60) LT EtOH/nC(60) LT aqU/nC(60)) of the solvent intercalated in the fullerene crystals determines their ability to produce ROS and cause cell damage. These data could. have important implications for toxicology and biomedical application of colloidal fullerenes. (C) 2007 Elsevier Ltd. All rights reserved.", journal = "Biomaterials", title = "The mechanism of cell-damaging reactive oxygen generation by colloidal fullerenes", volume = "28", number = "36", pages = "5437-5448", doi = "10.1016/j.biomaterials.2007.09.002" }
Marković, Z. M., Todorović-Marković, B., Kleut, D., Nikolić, N. S., Vranješ-Đurić, S., Misirkić, M., Vucicevic, L., Janjetović, K. D., Isaković, A. J., Harhaji, L. M., Babić-Stojić, B. S., Dramićanin, M.,& Trajković, V. S.. (2007). The mechanism of cell-damaging reactive oxygen generation by colloidal fullerenes. in Biomaterials, 28(36), 5437-5448. https://doi.org/10.1016/j.biomaterials.2007.09.002
Marković ZM, Todorović-Marković B, Kleut D, Nikolić NS, Vranješ-Đurić S, Misirkić M, Vucicevic L, Janjetović KD, Isaković AJ, Harhaji LM, Babić-Stojić BS, Dramićanin M, Trajković VS. The mechanism of cell-damaging reactive oxygen generation by colloidal fullerenes. in Biomaterials. 2007;28(36):5437-5448. doi:10.1016/j.biomaterials.2007.09.002 .
Marković, Zoran M., Todorović-Marković, Biljana, Kleut, Duška, Nikolić, Nadežda S., Vranješ-Đurić, Sanja, Misirkić, Maja, Vucicevic, Ljubica, Janjetović, Kristina D., Isaković, Aleksandra J., Harhaji, Ljubica M., Babić-Stojić, Branka S., Dramićanin, Miroslav, Trajković, Vladimir S., "The mechanism of cell-damaging reactive oxygen generation by colloidal fullerenes" in Biomaterials, 28, no. 36 (2007):5437-5448, https://doi.org/10.1016/j.biomaterials.2007.09.002 . .