QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries
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Sokka, TuulikkiKautiainen, Hannu
Toloza, Sergio
Makinen, Heidi
Verstappen, Suzan M. M.
Hetland, Merete Lund
Naranjo, Antonio
Baecklund, Eva
Herborn, Gertraud
Rau, Rolf
Cazzato, Massimiliano
Gossec, Laure
Skakic, Vlado
Gogus, Feride
Sierakowski, Stanislaw
Bresnihan, Barry
Taylor, Peter
McClinton, Catherine
Pincus, Theodore
the QUEST-RA Grp
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Objective: To conduct a cross- sectional review of non- selected consecutive outpatients with rheumatoid arthritis ( RA) as part of standard clinical care in 15 countries for an overview of the characteristics of patients with RA. Methods: The review included current disease activity using data from clinical assessment and a patient self-report questionnaire, which was translated into each language. Data on demographic, disease and treatment- related variables were collected and analysed using descriptive statistics. Variation in disease activity on DAS28 ( disease activity score on 28- joint count) within and between countries was graphically analysed. A median regression model was applied to analyse differences in disease activity between countries. Results: Between January 2005 and October 2006, the QUEST- RA ( Quantitative Patient Questionnaires in Standard Monitoring of Patients with Rheumatoid Arthritis) project included 4363 patients from 48 sites in 15 countries; 78% were femal...e,. GT 90% Caucasian, mean age was 57 years and mean disease duration was 11.5 years. More than 80% of patients had been treated with methotrexate in all but three countries. Overall, patients had an active disease with a median DAS28 of 4.0, with a significant variation between countries ( p LT 0.001). Among 42 sites with GT 50 patients included, low disease activity of DAS28 LT = 3.2 was found in the majority of patients in seven sites in five countries; in eight sites in five other countries, GT 50% of patients had high disease activity of DAS28 GT 5.1. Conclusions: This international multicentre cross- sectional database provides an overview of clinical status and treatments of patients with RA in standard clinical care in 2005 - 6 including countries that are infrequently involved in clinical research projects.
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Annals of the Rheumatic Diseases, 2007, 66, 11, 1491-1496
DOI: 10.1136/ard.2006.069252
ISSN: 0003-4967
PubMed: 17412740
WoS: 000250147900015
Scopus: 2-s2.0-34347388745
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VinčaTY - JOUR AU - Sokka, Tuulikki AU - Kautiainen, Hannu AU - Toloza, Sergio AU - Makinen, Heidi AU - Verstappen, Suzan M. M. AU - Hetland, Merete Lund AU - Naranjo, Antonio AU - Baecklund, Eva AU - Herborn, Gertraud AU - Rau, Rolf AU - Cazzato, Massimiliano AU - Gossec, Laure AU - Skakic, Vlado AU - Gogus, Feride AU - Sierakowski, Stanislaw AU - Bresnihan, Barry AU - Taylor, Peter AU - McClinton, Catherine AU - Pincus, Theodore AU - the QUEST-RA Grp PY - 2007 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3303 AB - Objective: To conduct a cross- sectional review of non- selected consecutive outpatients with rheumatoid arthritis ( RA) as part of standard clinical care in 15 countries for an overview of the characteristics of patients with RA. Methods: The review included current disease activity using data from clinical assessment and a patient self-report questionnaire, which was translated into each language. Data on demographic, disease and treatment- related variables were collected and analysed using descriptive statistics. Variation in disease activity on DAS28 ( disease activity score on 28- joint count) within and between countries was graphically analysed. A median regression model was applied to analyse differences in disease activity between countries. Results: Between January 2005 and October 2006, the QUEST- RA ( Quantitative Patient Questionnaires in Standard Monitoring of Patients with Rheumatoid Arthritis) project included 4363 patients from 48 sites in 15 countries; 78% were female,. GT 90% Caucasian, mean age was 57 years and mean disease duration was 11.5 years. More than 80% of patients had been treated with methotrexate in all but three countries. Overall, patients had an active disease with a median DAS28 of 4.0, with a significant variation between countries ( p LT 0.001). Among 42 sites with GT 50 patients included, low disease activity of DAS28 LT = 3.2 was found in the majority of patients in seven sites in five countries; in eight sites in five other countries, GT 50% of patients had high disease activity of DAS28 GT 5.1. Conclusions: This international multicentre cross- sectional database provides an overview of clinical status and treatments of patients with RA in standard clinical care in 2005 - 6 including countries that are infrequently involved in clinical research projects. T2 - Annals of the Rheumatic Diseases T1 - QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries VL - 66 IS - 11 SP - 1491 EP - 1496 DO - 10.1136/ard.2006.069252 ER -
@article{ author = "Sokka, Tuulikki and Kautiainen, Hannu and Toloza, Sergio and Makinen, Heidi and Verstappen, Suzan M. M. and Hetland, Merete Lund and Naranjo, Antonio and Baecklund, Eva and Herborn, Gertraud and Rau, Rolf and Cazzato, Massimiliano and Gossec, Laure and Skakic, Vlado and Gogus, Feride and Sierakowski, Stanislaw and Bresnihan, Barry and Taylor, Peter and McClinton, Catherine and Pincus, Theodore and the QUEST-RA Grp", year = "2007", abstract = "Objective: To conduct a cross- sectional review of non- selected consecutive outpatients with rheumatoid arthritis ( RA) as part of standard clinical care in 15 countries for an overview of the characteristics of patients with RA. Methods: The review included current disease activity using data from clinical assessment and a patient self-report questionnaire, which was translated into each language. Data on demographic, disease and treatment- related variables were collected and analysed using descriptive statistics. Variation in disease activity on DAS28 ( disease activity score on 28- joint count) within and between countries was graphically analysed. A median regression model was applied to analyse differences in disease activity between countries. Results: Between January 2005 and October 2006, the QUEST- RA ( Quantitative Patient Questionnaires in Standard Monitoring of Patients with Rheumatoid Arthritis) project included 4363 patients from 48 sites in 15 countries; 78% were female,. GT 90% Caucasian, mean age was 57 years and mean disease duration was 11.5 years. More than 80% of patients had been treated with methotrexate in all but three countries. Overall, patients had an active disease with a median DAS28 of 4.0, with a significant variation between countries ( p LT 0.001). Among 42 sites with GT 50 patients included, low disease activity of DAS28 LT = 3.2 was found in the majority of patients in seven sites in five countries; in eight sites in five other countries, GT 50% of patients had high disease activity of DAS28 GT 5.1. Conclusions: This international multicentre cross- sectional database provides an overview of clinical status and treatments of patients with RA in standard clinical care in 2005 - 6 including countries that are infrequently involved in clinical research projects.", journal = "Annals of the Rheumatic Diseases", title = "QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries", volume = "66", number = "11", pages = "1491-1496", doi = "10.1136/ard.2006.069252" }
Sokka, T., Kautiainen, H., Toloza, S., Makinen, H., Verstappen, S. M. M., Hetland, M. L., Naranjo, A., Baecklund, E., Herborn, G., Rau, R., Cazzato, M., Gossec, L., Skakic, V., Gogus, F., Sierakowski, S., Bresnihan, B., Taylor, P., McClinton, C., Pincus, T.,& the QUEST-RA Grp. (2007). QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries. in Annals of the Rheumatic Diseases, 66(11), 1491-1496. https://doi.org/10.1136/ard.2006.069252
Sokka T, Kautiainen H, Toloza S, Makinen H, Verstappen SMM, Hetland ML, Naranjo A, Baecklund E, Herborn G, Rau R, Cazzato M, Gossec L, Skakic V, Gogus F, Sierakowski S, Bresnihan B, Taylor P, McClinton C, Pincus T, the QUEST-RA Grp. QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries. in Annals of the Rheumatic Diseases. 2007;66(11):1491-1496. doi:10.1136/ard.2006.069252 .
Sokka, Tuulikki, Kautiainen, Hannu, Toloza, Sergio, Makinen, Heidi, Verstappen, Suzan M. M., Hetland, Merete Lund, Naranjo, Antonio, Baecklund, Eva, Herborn, Gertraud, Rau, Rolf, Cazzato, Massimiliano, Gossec, Laure, Skakic, Vlado, Gogus, Feride, Sierakowski, Stanislaw, Bresnihan, Barry, Taylor, Peter, McClinton, Catherine, Pincus, Theodore, the QUEST-RA Grp, "QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries" in Annals of the Rheumatic Diseases, 66, no. 11 (2007):1491-1496, https://doi.org/10.1136/ard.2006.069252 . .