Matrix metalloproteinase-9-1562 C/T gene polymorphism in Serbian patients with multiple sclerosis
Само за регистроване кориснике
2007
Аутори
Živković, MajaĐurić, Tamara
Dinčić, Evica
Raičević, Ranko
Alavantić, Dragan
Stanković, Aleksandra
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Matrix metalloproteinase-9 (MMP-9) is suggested to play a role in MS by mediating T cell migration across subendothelial basement membrane and by contribution to myelin breakdown. We studied the association of MMP-9 -1562 C/T gene polymorphisms with MS susceptibility and severity in 187 patients from Serbia. The significant decrease in T allele carriership (p=0.01), was found in female NIS patients, In addition, a trend toward lower MSSS in T allele carriers was noticed (CC, mean 5.7 +/- 2.5 vs. CT+TT, mean 4.9 +/- 2.5). Further studies in different populations are needed to resolve the potential influence of MMP-9 gene polymorphism on MS. (C) 2007 Elsevier B.V. All rights reserved.
Кључне речи:
MMP-9 / gene / polymorphism / multiple sclerosisИзвор:
Journal of Neuroimmunology, 2007, 189, 1-2, 147-150Финансирање / пројекти:
- Генетска eпидемиологија и фармакогеномика васкуларних обољења (RS-MESTD-MPN2006-2010-145023)
DOI: 10.1016/j.jneuroim.2007.06.022
ISSN: 0165-5728
PubMed: 17655938
WoS: 000250068800019
Scopus: 2-s2.0-34548542224
Колекције
Институција/група
VinčaTY - JOUR AU - Živković, Maja AU - Đurić, Tamara AU - Dinčić, Evica AU - Raičević, Ranko AU - Alavantić, Dragan AU - Stanković, Aleksandra PY - 2007 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3299 AB - Matrix metalloproteinase-9 (MMP-9) is suggested to play a role in MS by mediating T cell migration across subendothelial basement membrane and by contribution to myelin breakdown. We studied the association of MMP-9 -1562 C/T gene polymorphisms with MS susceptibility and severity in 187 patients from Serbia. The significant decrease in T allele carriership (p=0.01), was found in female NIS patients, In addition, a trend toward lower MSSS in T allele carriers was noticed (CC, mean 5.7 +/- 2.5 vs. CT+TT, mean 4.9 +/- 2.5). Further studies in different populations are needed to resolve the potential influence of MMP-9 gene polymorphism on MS. (C) 2007 Elsevier B.V. All rights reserved. T2 - Journal of Neuroimmunology T1 - Matrix metalloproteinase-9-1562 C/T gene polymorphism in Serbian patients with multiple sclerosis VL - 189 IS - 1-2 SP - 147 EP - 150 DO - 10.1016/j.jneuroim.2007.06.022 ER -
@article{ author = "Živković, Maja and Đurić, Tamara and Dinčić, Evica and Raičević, Ranko and Alavantić, Dragan and Stanković, Aleksandra", year = "2007", abstract = "Matrix metalloproteinase-9 (MMP-9) is suggested to play a role in MS by mediating T cell migration across subendothelial basement membrane and by contribution to myelin breakdown. We studied the association of MMP-9 -1562 C/T gene polymorphisms with MS susceptibility and severity in 187 patients from Serbia. The significant decrease in T allele carriership (p=0.01), was found in female NIS patients, In addition, a trend toward lower MSSS in T allele carriers was noticed (CC, mean 5.7 +/- 2.5 vs. CT+TT, mean 4.9 +/- 2.5). Further studies in different populations are needed to resolve the potential influence of MMP-9 gene polymorphism on MS. (C) 2007 Elsevier B.V. All rights reserved.", journal = "Journal of Neuroimmunology", title = "Matrix metalloproteinase-9-1562 C/T gene polymorphism in Serbian patients with multiple sclerosis", volume = "189", number = "1-2", pages = "147-150", doi = "10.1016/j.jneuroim.2007.06.022" }
Živković, M., Đurić, T., Dinčić, E., Raičević, R., Alavantić, D.,& Stanković, A.. (2007). Matrix metalloproteinase-9-1562 C/T gene polymorphism in Serbian patients with multiple sclerosis. in Journal of Neuroimmunology, 189(1-2), 147-150. https://doi.org/10.1016/j.jneuroim.2007.06.022
Živković M, Đurić T, Dinčić E, Raičević R, Alavantić D, Stanković A. Matrix metalloproteinase-9-1562 C/T gene polymorphism in Serbian patients with multiple sclerosis. in Journal of Neuroimmunology. 2007;189(1-2):147-150. doi:10.1016/j.jneuroim.2007.06.022 .
Živković, Maja, Đurić, Tamara, Dinčić, Evica, Raičević, Ranko, Alavantić, Dragan, Stanković, Aleksandra, "Matrix metalloproteinase-9-1562 C/T gene polymorphism in Serbian patients with multiple sclerosis" in Journal of Neuroimmunology, 189, no. 1-2 (2007):147-150, https://doi.org/10.1016/j.jneuroim.2007.06.022 . .