The presence of antibodies recognizing a peptide derived from the second conserved region of HIV-1 gp120 correlates with non-progressive HIV infection
Само за регистроване кориснике
2007
Аутори
Đorđević, AnaVeljković, Milena
Antoni, Sascha
Sakarellos-Daitsiotis, Maria
Krikorian, Dimitrios
Zevgiti, Stella
Dietrich, Ursula
Veljković, Nevena V.
Branch, Donald R.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The C-terminus of the second conserved region of HIV-1 gp120 represents a functionally important domain, as it encompasses amino acids directly involved in the binding to the CD4 receptor and in post-receptor binding events. Previous studies have suggested that antibodies with specific affinity to a 23 amino acids-long NTM polypeptide, derived from this HIV-1 gp120 domain, may be involved in the control of HIV disease progression. In the current work, we searched for NTM-recognizing antibodies in specific cohorts of HIV-1 infected individuals, including long-term non-progressors (LTNP) and progressors. For this purpose, we employed a previously defined bioinformatics criterion for design of an NTM peptide mimetic to select an octapeptide, NTMs (FTDNAKTI), which is more suitable for use in a solid-state enzyme-linked immunosorbent assay (ELISA). Our results show that NTMs-reactive antibodies are significantly more prevalent (p LT 0.01) in LTNP as compared to progressors and healthy cont...rol subjects, indicating their association with non-progressive infection. The presence of antibodies recognizing the second conserved region of the HIV-1 gp120 derived peptide, NTMs, in LTNP sera suggest that these antibodies could be of considerable interest for development of anti-HIV immune-based therapies and vaccines.
Кључне речи:
HIV long-term nonprogressors / C2 region of HIV-1 gp 120 / anti-NTM / NTM octapeptideИзвор:
Current HIV Research, 2007, 5, 5, 443-448Финансирање / пројекти:
- Идентификација и карактеризација ћелијских кофактора ХИВ-а и њихова могућа примена у превентиви и терапији (RS-MESTD-MPN2006-2010-143001)
DOI: 10.2174/157016207781662470
ISSN: 1570-162X
PubMed: 17896963
WoS: 000249955400001
Scopus: 2-s2.0-35348821222
Колекције
Институција/група
VinčaTY - JOUR AU - Đorđević, Ana AU - Veljković, Milena AU - Antoni, Sascha AU - Sakarellos-Daitsiotis, Maria AU - Krikorian, Dimitrios AU - Zevgiti, Stella AU - Dietrich, Ursula AU - Veljković, Nevena V. AU - Branch, Donald R. PY - 2007 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3295 AB - The C-terminus of the second conserved region of HIV-1 gp120 represents a functionally important domain, as it encompasses amino acids directly involved in the binding to the CD4 receptor and in post-receptor binding events. Previous studies have suggested that antibodies with specific affinity to a 23 amino acids-long NTM polypeptide, derived from this HIV-1 gp120 domain, may be involved in the control of HIV disease progression. In the current work, we searched for NTM-recognizing antibodies in specific cohorts of HIV-1 infected individuals, including long-term non-progressors (LTNP) and progressors. For this purpose, we employed a previously defined bioinformatics criterion for design of an NTM peptide mimetic to select an octapeptide, NTMs (FTDNAKTI), which is more suitable for use in a solid-state enzyme-linked immunosorbent assay (ELISA). Our results show that NTMs-reactive antibodies are significantly more prevalent (p LT 0.01) in LTNP as compared to progressors and healthy control subjects, indicating their association with non-progressive infection. The presence of antibodies recognizing the second conserved region of the HIV-1 gp120 derived peptide, NTMs, in LTNP sera suggest that these antibodies could be of considerable interest for development of anti-HIV immune-based therapies and vaccines. T2 - Current HIV Research T1 - The presence of antibodies recognizing a peptide derived from the second conserved region of HIV-1 gp120 correlates with non-progressive HIV infection VL - 5 IS - 5 SP - 443 EP - 448 DO - 10.2174/157016207781662470 ER -
@article{ author = "Đorđević, Ana and Veljković, Milena and Antoni, Sascha and Sakarellos-Daitsiotis, Maria and Krikorian, Dimitrios and Zevgiti, Stella and Dietrich, Ursula and Veljković, Nevena V. and Branch, Donald R.", year = "2007", abstract = "The C-terminus of the second conserved region of HIV-1 gp120 represents a functionally important domain, as it encompasses amino acids directly involved in the binding to the CD4 receptor and in post-receptor binding events. Previous studies have suggested that antibodies with specific affinity to a 23 amino acids-long NTM polypeptide, derived from this HIV-1 gp120 domain, may be involved in the control of HIV disease progression. In the current work, we searched for NTM-recognizing antibodies in specific cohorts of HIV-1 infected individuals, including long-term non-progressors (LTNP) and progressors. For this purpose, we employed a previously defined bioinformatics criterion for design of an NTM peptide mimetic to select an octapeptide, NTMs (FTDNAKTI), which is more suitable for use in a solid-state enzyme-linked immunosorbent assay (ELISA). Our results show that NTMs-reactive antibodies are significantly more prevalent (p LT 0.01) in LTNP as compared to progressors and healthy control subjects, indicating their association with non-progressive infection. The presence of antibodies recognizing the second conserved region of the HIV-1 gp120 derived peptide, NTMs, in LTNP sera suggest that these antibodies could be of considerable interest for development of anti-HIV immune-based therapies and vaccines.", journal = "Current HIV Research", title = "The presence of antibodies recognizing a peptide derived from the second conserved region of HIV-1 gp120 correlates with non-progressive HIV infection", volume = "5", number = "5", pages = "443-448", doi = "10.2174/157016207781662470" }
Đorđević, A., Veljković, M., Antoni, S., Sakarellos-Daitsiotis, M., Krikorian, D., Zevgiti, S., Dietrich, U., Veljković, N. V.,& Branch, D. R.. (2007). The presence of antibodies recognizing a peptide derived from the second conserved region of HIV-1 gp120 correlates with non-progressive HIV infection. in Current HIV Research, 5(5), 443-448. https://doi.org/10.2174/157016207781662470
Đorđević A, Veljković M, Antoni S, Sakarellos-Daitsiotis M, Krikorian D, Zevgiti S, Dietrich U, Veljković NV, Branch DR. The presence of antibodies recognizing a peptide derived from the second conserved region of HIV-1 gp120 correlates with non-progressive HIV infection. in Current HIV Research. 2007;5(5):443-448. doi:10.2174/157016207781662470 .
Đorđević, Ana, Veljković, Milena, Antoni, Sascha, Sakarellos-Daitsiotis, Maria, Krikorian, Dimitrios, Zevgiti, Stella, Dietrich, Ursula, Veljković, Nevena V., Branch, Donald R., "The presence of antibodies recognizing a peptide derived from the second conserved region of HIV-1 gp120 correlates with non-progressive HIV infection" in Current HIV Research, 5, no. 5 (2007):443-448, https://doi.org/10.2174/157016207781662470 . .