dc.creator | Isaković, Aleksandra J. | |
dc.creator | Marković, Zoran M. | |
dc.creator | Nikolić, Nadežda S. | |
dc.creator | Todorović-Marković, Biljana | |
dc.creator | Vranješ-Đurić, Sanja | |
dc.creator | Harhaji, Ljubica M. | |
dc.creator | Raičević, Nevena | |
dc.creator | Romčević, Nebojša Ž. | |
dc.creator | Vasiljević-Radović, Dana | |
dc.creator | Dramićanin, Miroslav | |
dc.creator | Trajković, Vladimir S. | |
dc.date.accessioned | 2018-03-01T19:54:02Z | |
dc.date.available | 2018-03-01T19:54:02Z | |
dc.date.issued | 2006 | |
dc.identifier.issn | 0142-9612 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/3076 | |
dc.description.abstract | We investigated the effect of gamma-irradiation on the cytotoxicity of pure C-60 solubilized in water by using tetrahydrofuran (THF/n-C-60 or THF/n-C-60). In contrast to THF/n-C-60, its gamma-irradiated counterpart failed to generate oxygen radicals and cause extracellular signal-regulated kinase (ERK)-dependent necrotic cell death in various types of mammalian cells. Moreover, gamma-irradiated THF/n-C-60 protected cells from the oxidative stress induced by native THF/n-C-60 or hydrogen peroxide. The observed biological effects were associated with of THF and subsequent derivatization of the n-C-60 surface. These results for the first time demonstrate gamma-irradiation-mediated changes in the physico-chemical properties of THF-prepared nanocrystalline C-60, resulting in a complete loss of its cytotoxic effect and its conversion to a cytoprotective agent. (c) 2006 Elsevier Ltd. All rights reserved. | en |
dc.rights | restrictedAccess | en |
dc.source | Biomaterials | en |
dc.subject | carbon | en |
dc.subject | nanoparticle | en |
dc.subject | gamma irradiation | en |
dc.subject | cytotoxicity | en |
dc.subject | antioxidant | en |
dc.title | Inactivation of nanocrystalline C-60 cytotoxicity by gamma-irradiation | en |
dc.type | article | en |
dcterms.abstract | Исаковиц, Aлександра; Николиц, Надезда; Хархаји, Љубица; Ромцевиц, Небојса; Марковић Зоран; Тодоровић-Марковић Биљана; Врањеш-Дјурић Сања; Раичевић Невена; Васиљевиц-Радовиц, Дана; Драмићанин Мирослав; Трајковиц, Владимир; | |
dc.citation.volume | 27 | |
dc.citation.issue | 29 | |
dc.citation.spage | 5049 | |
dc.citation.epage | 5058 | |
dc.identifier.wos | 000240167500005 | |
dc.identifier.doi | 10.1016/j.biomaterials.2006.05.047 | |
dc.citation.rank | M21a | |
dc.identifier.pmid | 16784774 | |
dc.identifier.scopus | 2-s2.0-33745272220 | |