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Acid-base equilibria of 2,4-diiodo-6-methylphenylearbamoylmethyl iminodiacetic acid and its labeling with technetium-99m
dc.creator | Brborić, Jasmina | |
dc.creator | Jovanović, Moma S. | |
dc.creator | Popovic, G | |
dc.creator | Kapetanovic, V | |
dc.creator | Vladimirov, Sote | |
dc.date.accessioned | 2018-03-01T19:45:58Z | |
dc.date.available | 2018-03-01T19:45:58Z | |
dc.date.issued | 2006 | |
dc.identifier.issn | 0352-5139 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/2981 | |
dc.description.abstract | The acid-base equilibria of a novel hepatobiliary imaging agent, 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid (DIIODIDA) were studied. The potentiometrically determined acidity constants of the second carboxylic group, amino and amide groups were pK(2) = 2.52 +/- 0.02; pK(3) = 5.86 +/- 0.06 and pK(4) = 10.9 +/- 0.1. The determinations were performed at 25 degrees C and an ionic strength of 0.1 mol/dm(3) (NaCl). The acidity constants (pK(1) = 1.3 +/- 0.4) corresponding to the first carboxylic group was determined indirectly, on the basis of equilibrium constants obtained in a heterogeneous system, at 25 degrees C and an ionic strength 1 mol/dm(3) (HCl, NaCl). DIIODIDA was labeled with teclinctiurn-99m, and the influence of pH on the yield of labeling was investigated. It was found that labeling within the pH range from 5.5 to 6.5 provided a radiopharmaceutical of high radiochemical purity ( GT 98%). | en |
dc.rights | openAccess | en |
dc.source | Journal of the Serbian Chemical Society | en |
dc.subject | iminodiacetic acid analogues | en |
dc.subject | acidity constants | en |
dc.subject | hepatobiliary agent | en |
dc.subject | technetium-99m | en |
dc.title | Acid-base equilibria of 2,4-diiodo-6-methylphenylearbamoylmethyl iminodiacetic acid and its labeling with technetium-99m | en |
dc.type | article | en |
dcterms.abstract | Брбориц, ЈС; Јовановиц, МС; Капетановиц, В; Владимиров, С; Поповиц, Г; | |
dc.citation.volume | 71 | |
dc.citation.issue | 1 | |
dc.citation.spage | 55 | |
dc.citation.epage | 65 | |
dc.identifier.wos | 000235562500006 | |
dc.identifier.doi | 10.2298/JSC0601055B | |
dc.citation.rank | M23 | |
dc.identifier.scopus | 2-s2.0-33644966489 | |
dc.identifier.fulltext | https://vinar.vin.bg.ac.rs//bitstream/id/12357/2977.pdf |