Endothelial NOS G894T and MMP-3 5A/6A gene polymorphisms and hypertension in Serbian population
Апстракт
The incidence of hypertension is increasing and it is more common in man than in women. Up to date, MMP-3 5A/6A polymorphism has been associated with artery stiffening and elevated blood pressure, whereas results considering association of endothelial NOS (eNOS) G894T polymorphism with hypertension are controversial. The aim of our study was to analyze the possible association of eNOS G894T and MMP-3 5A/6A gene polymorphisms with hypertension in Serbian population. Study sample consisted of 172 hypertensive and 200 normotensive subjects divided by gender. Both female and male group was truncated according to age. All subjects were genotyped for MMP-3 5A/6A and eNOS G894T polymorphism. There was a significantly higher (P LT 0.05) prevalence of 5A/5A genotype in hypertensive females compared to normotensive ones (19.30% vs. 10.84%) even more pronounced in group GT = 50 years, according to its recessive effect. In young males ( LT 40 years), we found 3.7-fold increased risk for hypertensi...on associated with allele 6A (P LT 0.01), and 8.1-fold with genotype 6A/6A (P=0.01) according to recessive model. We found no association of eNOS G894T polymorphism with hypertension. These results indicate that there were gender-and age-specific differences in association of MMP-3 5A/6A polymorphism with hyperin Serbian population.
Кључне речи:
gender-specific association / endothelial nitric oxide synthase / matrix metalloproteinaseИзвор:
Journal of Clinical Laboratory Analysis, 2005, 19, 6, 241-246
DOI: 10.1002/jcla.20085
ISSN: 0887-8013
PubMed: 16302209
WoS: 000233701100003
Scopus: 2-s2.0-28444460716
Колекције
Институција/група
VinčaTY - JOUR AU - Đurić, Tamara AU - Živković, Maja AU - Stanković, Aleksandra AU - Mečanin, Sanja AU - Alavantić, Dragan PY - 2005 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2949 AB - The incidence of hypertension is increasing and it is more common in man than in women. Up to date, MMP-3 5A/6A polymorphism has been associated with artery stiffening and elevated blood pressure, whereas results considering association of endothelial NOS (eNOS) G894T polymorphism with hypertension are controversial. The aim of our study was to analyze the possible association of eNOS G894T and MMP-3 5A/6A gene polymorphisms with hypertension in Serbian population. Study sample consisted of 172 hypertensive and 200 normotensive subjects divided by gender. Both female and male group was truncated according to age. All subjects were genotyped for MMP-3 5A/6A and eNOS G894T polymorphism. There was a significantly higher (P LT 0.05) prevalence of 5A/5A genotype in hypertensive females compared to normotensive ones (19.30% vs. 10.84%) even more pronounced in group GT = 50 years, according to its recessive effect. In young males ( LT 40 years), we found 3.7-fold increased risk for hypertension associated with allele 6A (P LT 0.01), and 8.1-fold with genotype 6A/6A (P=0.01) according to recessive model. We found no association of eNOS G894T polymorphism with hypertension. These results indicate that there were gender-and age-specific differences in association of MMP-3 5A/6A polymorphism with hyperin Serbian population. T2 - Journal of Clinical Laboratory Analysis T1 - Endothelial NOS G894T and MMP-3 5A/6A gene polymorphisms and hypertension in Serbian population VL - 19 IS - 6 SP - 241 EP - 246 DO - 10.1002/jcla.20085 ER -
@article{ author = "Đurić, Tamara and Živković, Maja and Stanković, Aleksandra and Mečanin, Sanja and Alavantić, Dragan", year = "2005", abstract = "The incidence of hypertension is increasing and it is more common in man than in women. Up to date, MMP-3 5A/6A polymorphism has been associated with artery stiffening and elevated blood pressure, whereas results considering association of endothelial NOS (eNOS) G894T polymorphism with hypertension are controversial. The aim of our study was to analyze the possible association of eNOS G894T and MMP-3 5A/6A gene polymorphisms with hypertension in Serbian population. Study sample consisted of 172 hypertensive and 200 normotensive subjects divided by gender. Both female and male group was truncated according to age. All subjects were genotyped for MMP-3 5A/6A and eNOS G894T polymorphism. There was a significantly higher (P LT 0.05) prevalence of 5A/5A genotype in hypertensive females compared to normotensive ones (19.30% vs. 10.84%) even more pronounced in group GT = 50 years, according to its recessive effect. In young males ( LT 40 years), we found 3.7-fold increased risk for hypertension associated with allele 6A (P LT 0.01), and 8.1-fold with genotype 6A/6A (P=0.01) according to recessive model. We found no association of eNOS G894T polymorphism with hypertension. These results indicate that there were gender-and age-specific differences in association of MMP-3 5A/6A polymorphism with hyperin Serbian population.", journal = "Journal of Clinical Laboratory Analysis", title = "Endothelial NOS G894T and MMP-3 5A/6A gene polymorphisms and hypertension in Serbian population", volume = "19", number = "6", pages = "241-246", doi = "10.1002/jcla.20085" }
Đurić, T., Živković, M., Stanković, A., Mečanin, S.,& Alavantić, D.. (2005). Endothelial NOS G894T and MMP-3 5A/6A gene polymorphisms and hypertension in Serbian population. in Journal of Clinical Laboratory Analysis, 19(6), 241-246. https://doi.org/10.1002/jcla.20085
Đurić T, Živković M, Stanković A, Mečanin S, Alavantić D. Endothelial NOS G894T and MMP-3 5A/6A gene polymorphisms and hypertension in Serbian population. in Journal of Clinical Laboratory Analysis. 2005;19(6):241-246. doi:10.1002/jcla.20085 .
Đurić, Tamara, Živković, Maja, Stanković, Aleksandra, Mečanin, Sanja, Alavantić, Dragan, "Endothelial NOS G894T and MMP-3 5A/6A gene polymorphisms and hypertension in Serbian population" in Journal of Clinical Laboratory Analysis, 19, no. 6 (2005):241-246, https://doi.org/10.1002/jcla.20085 . .