Estradiol In Vivo Induces Changes in Cardiomyocytes Size in Obese Rats
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2015
Autori
Obradović, Milan M.Sudar, Emina
Zafirović, Sonja
Stanimirović, Julijana
Labudović-Borović, Milica
Isenović, Esma R.
Članak u časopisu (Objavljena verzija)
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We studied the in vivo effects of estradiol on size and biochemical parameters of cardiomyocytes in pathophysiological conditions such as obesity and insulin resistance. Male Wistar rats were normally fed (controls, n = 7) or fed with high-fat diet (obese, n = 14). Half of the obese rats (obese + estradiol, n = 7) were treated with a single dose of estradiol (40 g/kg, intraperitoneally) and 24 hours after treatment all the rats were killed. Estradiol in vivo in obese rats resulted in a significant increase in protein kinase B (Akt) activation (P LT .05) and decrease in heart mass (P LT .05), ratio of the heart mass/body mass (P LT .05), transverse diameters of cardiomyocytes (P LT .001), concentration of serum high-sensitivity C-reactive protein (P LT .001), and total cholesterol (P LT .01) compared with obese nontreated rats. Our results suggest that estradiol in obese/IR rats affects the size of cardiomyocytes and its actions lead in vivo to a reduction in obesity-induced cardiac hyp...ertrophy, via Akt.
Ključne reči:
estradiol / cardiac hypertrophy / obesity / IRIzvor:
Angiology, 2015, 66, 1, 25-35Finansiranje / projekti:
- Hormonska regulacija ekspresije i aktivnosti azot oksid sintaze i natrijum-kalijumove pumpe u eksperimentalnim modelima insulinske rezistencije, dijabetesa i kardiovaskularnih poremećaja (RS-MESTD-Basic Research (BR or ON)-173033)
DOI: 10.1177/0003319713514477
ISSN: 0003-3197; 1940-1574
PubMed: 24327768
WoS: 000346181900003
Scopus: 2-s2.0-84927172355
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Obradović, Milan M. AU - Sudar, Emina AU - Zafirović, Sonja AU - Stanimirović, Julijana AU - Labudović-Borović, Milica AU - Isenović, Esma R. PY - 2015 UR - https://vinar.vin.bg.ac.rs/handle/123456789/286 AB - We studied the in vivo effects of estradiol on size and biochemical parameters of cardiomyocytes in pathophysiological conditions such as obesity and insulin resistance. Male Wistar rats were normally fed (controls, n = 7) or fed with high-fat diet (obese, n = 14). Half of the obese rats (obese + estradiol, n = 7) were treated with a single dose of estradiol (40 g/kg, intraperitoneally) and 24 hours after treatment all the rats were killed. Estradiol in vivo in obese rats resulted in a significant increase in protein kinase B (Akt) activation (P LT .05) and decrease in heart mass (P LT .05), ratio of the heart mass/body mass (P LT .05), transverse diameters of cardiomyocytes (P LT .001), concentration of serum high-sensitivity C-reactive protein (P LT .001), and total cholesterol (P LT .01) compared with obese nontreated rats. Our results suggest that estradiol in obese/IR rats affects the size of cardiomyocytes and its actions lead in vivo to a reduction in obesity-induced cardiac hypertrophy, via Akt. T2 - Angiology T1 - Estradiol In Vivo Induces Changes in Cardiomyocytes Size in Obese Rats VL - 66 IS - 1 SP - 25 EP - 35 DO - 10.1177/0003319713514477 ER -
@article{ author = "Obradović, Milan M. and Sudar, Emina and Zafirović, Sonja and Stanimirović, Julijana and Labudović-Borović, Milica and Isenović, Esma R.", year = "2015", abstract = "We studied the in vivo effects of estradiol on size and biochemical parameters of cardiomyocytes in pathophysiological conditions such as obesity and insulin resistance. Male Wistar rats were normally fed (controls, n = 7) or fed with high-fat diet (obese, n = 14). Half of the obese rats (obese + estradiol, n = 7) were treated with a single dose of estradiol (40 g/kg, intraperitoneally) and 24 hours after treatment all the rats were killed. Estradiol in vivo in obese rats resulted in a significant increase in protein kinase B (Akt) activation (P LT .05) and decrease in heart mass (P LT .05), ratio of the heart mass/body mass (P LT .05), transverse diameters of cardiomyocytes (P LT .001), concentration of serum high-sensitivity C-reactive protein (P LT .001), and total cholesterol (P LT .01) compared with obese nontreated rats. Our results suggest that estradiol in obese/IR rats affects the size of cardiomyocytes and its actions lead in vivo to a reduction in obesity-induced cardiac hypertrophy, via Akt.", journal = "Angiology", title = "Estradiol In Vivo Induces Changes in Cardiomyocytes Size in Obese Rats", volume = "66", number = "1", pages = "25-35", doi = "10.1177/0003319713514477" }
Obradović, M. M., Sudar, E., Zafirović, S., Stanimirović, J., Labudović-Borović, M.,& Isenović, E. R.. (2015). Estradiol In Vivo Induces Changes in Cardiomyocytes Size in Obese Rats. in Angiology, 66(1), 25-35. https://doi.org/10.1177/0003319713514477
Obradović MM, Sudar E, Zafirović S, Stanimirović J, Labudović-Borović M, Isenović ER. Estradiol In Vivo Induces Changes in Cardiomyocytes Size in Obese Rats. in Angiology. 2015;66(1):25-35. doi:10.1177/0003319713514477 .
Obradović, Milan M., Sudar, Emina, Zafirović, Sonja, Stanimirović, Julijana, Labudović-Borović, Milica, Isenović, Esma R., "Estradiol In Vivo Induces Changes in Cardiomyocytes Size in Obese Rats" in Angiology, 66, no. 1 (2015):25-35, https://doi.org/10.1177/0003319713514477 . .