Antibodies reactive with C-terminus of the second conserved region of HIV-1gp120 as possible prognostic marker and therapeutic agent for HIV disease
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2004
Authors
Veljković, Nevena V.Branch, DR
Metlaš, Radmila
Prljić, Jelena
Manfredi, R
Stringer, WW
Veljković, Veljko
Article (Published version)
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It has been reported that antibodies reactive with peptide RSANFTDNAKTIIVQLNQSVEIN (peptide NTM) derived from the C-terminus of the second conserved domain of HIV-1 envelope glycoprotein gp120 could represent an important factor in control of the HIV disease. In order to check this notion we (i) tested reactivity with peptide NTM serum samples collected from 310 consecutive HIV-1 infected patients with a CD4(+) lymphocyte count ranging from 10 to 800/muL and (ii) performed the longitudinal study that included 107 sera samples collected from 29 HIV patients. Results of these studies demonstrated correlation between presence of anti-NTM antibodies in sera of HIV patients and disease progression measured by the CD4(+) cell count. Based on these findings we proposed the anti-NTM antibodies as useful prognostic marker for HIV disease. (C) 2004 Elsevier B.V. All rights reserved.
Keywords:
antibodies / serum samples / HIV patientsSource:
Journal of Clinical Virology, 2004, 31, S39-S44
DOI: 10.1016/j.jcv.2004.09.012
ISSN: 1386-6532
PubMed: 15567092
WoS: 000225826700006
Scopus: 2-s2.0-9644307937
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VinčaTY - JOUR AU - Veljković, Nevena V. AU - Branch, DR AU - Metlaš, Radmila AU - Prljić, Jelena AU - Manfredi, R AU - Stringer, WW AU - Veljković, Veljko PY - 2004 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2837 AB - It has been reported that antibodies reactive with peptide RSANFTDNAKTIIVQLNQSVEIN (peptide NTM) derived from the C-terminus of the second conserved domain of HIV-1 envelope glycoprotein gp120 could represent an important factor in control of the HIV disease. In order to check this notion we (i) tested reactivity with peptide NTM serum samples collected from 310 consecutive HIV-1 infected patients with a CD4(+) lymphocyte count ranging from 10 to 800/muL and (ii) performed the longitudinal study that included 107 sera samples collected from 29 HIV patients. Results of these studies demonstrated correlation between presence of anti-NTM antibodies in sera of HIV patients and disease progression measured by the CD4(+) cell count. Based on these findings we proposed the anti-NTM antibodies as useful prognostic marker for HIV disease. (C) 2004 Elsevier B.V. All rights reserved. T2 - Journal of Clinical Virology T1 - Antibodies reactive with C-terminus of the second conserved region of HIV-1gp120 as possible prognostic marker and therapeutic agent for HIV disease VL - 31 SP - S39 EP - S44 DO - 10.1016/j.jcv.2004.09.012 ER -
@article{ author = "Veljković, Nevena V. and Branch, DR and Metlaš, Radmila and Prljić, Jelena and Manfredi, R and Stringer, WW and Veljković, Veljko", year = "2004", abstract = "It has been reported that antibodies reactive with peptide RSANFTDNAKTIIVQLNQSVEIN (peptide NTM) derived from the C-terminus of the second conserved domain of HIV-1 envelope glycoprotein gp120 could represent an important factor in control of the HIV disease. In order to check this notion we (i) tested reactivity with peptide NTM serum samples collected from 310 consecutive HIV-1 infected patients with a CD4(+) lymphocyte count ranging from 10 to 800/muL and (ii) performed the longitudinal study that included 107 sera samples collected from 29 HIV patients. Results of these studies demonstrated correlation between presence of anti-NTM antibodies in sera of HIV patients and disease progression measured by the CD4(+) cell count. Based on these findings we proposed the anti-NTM antibodies as useful prognostic marker for HIV disease. (C) 2004 Elsevier B.V. All rights reserved.", journal = "Journal of Clinical Virology", title = "Antibodies reactive with C-terminus of the second conserved region of HIV-1gp120 as possible prognostic marker and therapeutic agent for HIV disease", volume = "31", pages = "S39-S44", doi = "10.1016/j.jcv.2004.09.012" }
Veljković, N. V., Branch, D., Metlaš, R., Prljić, J., Manfredi, R., Stringer, W.,& Veljković, V.. (2004). Antibodies reactive with C-terminus of the second conserved region of HIV-1gp120 as possible prognostic marker and therapeutic agent for HIV disease. in Journal of Clinical Virology, 31, S39-S44. https://doi.org/10.1016/j.jcv.2004.09.012
Veljković NV, Branch D, Metlaš R, Prljić J, Manfredi R, Stringer W, Veljković V. Antibodies reactive with C-terminus of the second conserved region of HIV-1gp120 as possible prognostic marker and therapeutic agent for HIV disease. in Journal of Clinical Virology. 2004;31:S39-S44. doi:10.1016/j.jcv.2004.09.012 .
Veljković, Nevena V., Branch, DR, Metlaš, Radmila, Prljić, Jelena, Manfredi, R, Stringer, WW, Veljković, Veljko, "Antibodies reactive with C-terminus of the second conserved region of HIV-1gp120 as possible prognostic marker and therapeutic agent for HIV disease" in Journal of Clinical Virology, 31 (2004):S39-S44, https://doi.org/10.1016/j.jcv.2004.09.012 . .