HIV-1 gp120 and immune network
Apstrakt
It has been demonstrated that the immunodominant V3 loop of HIV-1 gp120 and its flanking regions bear sequence and structural homology to the framework and complementarity-determining regions of human immunoglobulins. It has been proposed that the Ig-like domain of gp120 might encode idiotypes and in this way permit HIV-1 entry into the immune regulatory network. This notion is strongly supported by results demonstrating that the anti-V3 loop and anti-Ig antibodies of healthy individuals share complementary structure and that V3 reactive antibodies are present in HIV-negative sera. This might be the mechanism by which HIV induces immunological abnormalities, and it should be taken into consideration in AIDS vaccine development.
Ključne reči:
HIV-1 / gp120 / V3 loop / immunoglobulin / immune networkIzvor:
International Reviews of Immunology, 2004, 23, 5-6, 413-422
DOI: 10.1080/08830180490432758
ISSN: 0883-0185
PubMed: 15370273
WoS: 000223983900004
Scopus: 2-s2.0-4644221855
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Metlaš, Radmila AU - Veljković, Veljko PY - 2004 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2806 AB - It has been demonstrated that the immunodominant V3 loop of HIV-1 gp120 and its flanking regions bear sequence and structural homology to the framework and complementarity-determining regions of human immunoglobulins. It has been proposed that the Ig-like domain of gp120 might encode idiotypes and in this way permit HIV-1 entry into the immune regulatory network. This notion is strongly supported by results demonstrating that the anti-V3 loop and anti-Ig antibodies of healthy individuals share complementary structure and that V3 reactive antibodies are present in HIV-negative sera. This might be the mechanism by which HIV induces immunological abnormalities, and it should be taken into consideration in AIDS vaccine development. T2 - International Reviews of Immunology T1 - HIV-1 gp120 and immune network VL - 23 IS - 5-6 SP - 413 EP - 422 DO - 10.1080/08830180490432758 ER -
@article{ author = "Metlaš, Radmila and Veljković, Veljko", year = "2004", abstract = "It has been demonstrated that the immunodominant V3 loop of HIV-1 gp120 and its flanking regions bear sequence and structural homology to the framework and complementarity-determining regions of human immunoglobulins. It has been proposed that the Ig-like domain of gp120 might encode idiotypes and in this way permit HIV-1 entry into the immune regulatory network. This notion is strongly supported by results demonstrating that the anti-V3 loop and anti-Ig antibodies of healthy individuals share complementary structure and that V3 reactive antibodies are present in HIV-negative sera. This might be the mechanism by which HIV induces immunological abnormalities, and it should be taken into consideration in AIDS vaccine development.", journal = "International Reviews of Immunology", title = "HIV-1 gp120 and immune network", volume = "23", number = "5-6", pages = "413-422", doi = "10.1080/08830180490432758" }
Metlaš, R.,& Veljković, V.. (2004). HIV-1 gp120 and immune network. in International Reviews of Immunology, 23(5-6), 413-422. https://doi.org/10.1080/08830180490432758
Metlaš R, Veljković V. HIV-1 gp120 and immune network. in International Reviews of Immunology. 2004;23(5-6):413-422. doi:10.1080/08830180490432758 .
Metlaš, Radmila, Veljković, Veljko, "HIV-1 gp120 and immune network" in International Reviews of Immunology, 23, no. 5-6 (2004):413-422, https://doi.org/10.1080/08830180490432758 . .