The effect of ovarian hormones on antioxidant enzyme activities in the brain of male rats
Abstract
The brain is widely responsive to gonadal hormones. The functional significance of ovarian hormones in the brain is evident from biochemical studies indicating that estradiol or progesterone treatment of testectomized rats produces changes of antioxidant enzyme activities. The effect of estradiol benzoate (EB) and progesterone (P) in the control of antioxidant (AO) enzyme activities was studied in the brain of adult male Wistar rats. The activities of catalase (CAT), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST) and glutathione reductase (GR) were measured in appropriate subcellular fractions, prepared from brains of animals belonging to various experimental groups. These groups were designed with the intention to follow changes in enzyme activities 2 h or 24 h after systemic administration of 5 mug EB or 2 mg P to testectomized (TX) animals. The obtained results show that both EB and P increase CAT activity, whereas EB decreases GSH-Px, GST and GR activities. These ...findings clearly show the modulatory role of EB and P in the control of enzymes responsible for the protection of rat nerve cells against oxidative damage caused by free oxygen radicals.
Keywords:
brain / antioxidant enzymes / estradiol / progesterone / ratsSource:
Physiological Research, 2003, 52, 2, 189-194Collections
Institution/Community
VinčaTY - JOUR AU - Pajović, Snežana B. AU - Saičić, Zorica S. AU - Spasić, Mihajlo AU - Petrović, Vojislav M. PY - 2003 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2628 AB - The brain is widely responsive to gonadal hormones. The functional significance of ovarian hormones in the brain is evident from biochemical studies indicating that estradiol or progesterone treatment of testectomized rats produces changes of antioxidant enzyme activities. The effect of estradiol benzoate (EB) and progesterone (P) in the control of antioxidant (AO) enzyme activities was studied in the brain of adult male Wistar rats. The activities of catalase (CAT), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST) and glutathione reductase (GR) were measured in appropriate subcellular fractions, prepared from brains of animals belonging to various experimental groups. These groups were designed with the intention to follow changes in enzyme activities 2 h or 24 h after systemic administration of 5 mug EB or 2 mg P to testectomized (TX) animals. The obtained results show that both EB and P increase CAT activity, whereas EB decreases GSH-Px, GST and GR activities. These findings clearly show the modulatory role of EB and P in the control of enzymes responsible for the protection of rat nerve cells against oxidative damage caused by free oxygen radicals. T2 - Physiological Research T1 - The effect of ovarian hormones on antioxidant enzyme activities in the brain of male rats VL - 52 IS - 2 SP - 189 EP - 194 UR - https://hdl.handle.net/21.15107/rcub_vinar_2628 ER -
@article{ author = "Pajović, Snežana B. and Saičić, Zorica S. and Spasić, Mihajlo and Petrović, Vojislav M.", year = "2003", abstract = "The brain is widely responsive to gonadal hormones. The functional significance of ovarian hormones in the brain is evident from biochemical studies indicating that estradiol or progesterone treatment of testectomized rats produces changes of antioxidant enzyme activities. The effect of estradiol benzoate (EB) and progesterone (P) in the control of antioxidant (AO) enzyme activities was studied in the brain of adult male Wistar rats. The activities of catalase (CAT), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST) and glutathione reductase (GR) were measured in appropriate subcellular fractions, prepared from brains of animals belonging to various experimental groups. These groups were designed with the intention to follow changes in enzyme activities 2 h or 24 h after systemic administration of 5 mug EB or 2 mg P to testectomized (TX) animals. The obtained results show that both EB and P increase CAT activity, whereas EB decreases GSH-Px, GST and GR activities. These findings clearly show the modulatory role of EB and P in the control of enzymes responsible for the protection of rat nerve cells against oxidative damage caused by free oxygen radicals.", journal = "Physiological Research", title = "The effect of ovarian hormones on antioxidant enzyme activities in the brain of male rats", volume = "52", number = "2", pages = "189-194", url = "https://hdl.handle.net/21.15107/rcub_vinar_2628" }
Pajović, S. B., Saičić, Z. S., Spasić, M.,& Petrović, V. M.. (2003). The effect of ovarian hormones on antioxidant enzyme activities in the brain of male rats. in Physiological Research, 52(2), 189-194. https://hdl.handle.net/21.15107/rcub_vinar_2628
Pajović SB, Saičić ZS, Spasić M, Petrović VM. The effect of ovarian hormones on antioxidant enzyme activities in the brain of male rats. in Physiological Research. 2003;52(2):189-194. https://hdl.handle.net/21.15107/rcub_vinar_2628 .
Pajović, Snežana B., Saičić, Zorica S., Spasić, Mihajlo, Petrović, Vojislav M., "The effect of ovarian hormones on antioxidant enzyme activities in the brain of male rats" in Physiological Research, 52, no. 2 (2003):189-194, https://hdl.handle.net/21.15107/rcub_vinar_2628 .