Statistical evaluation of the quality control results of Tc-99m(Sn)-DPD
Апстракт
The results of the quality control of Tc-99m-DPD produced during five consequtive years are statistically evaluated. Radiochemical purity of the kit determined in 75 batches was 98.3+/-1.3%. TLC on silica gel with the mixture of acetone and methanole (1:1, v/v) was used to determine the content of free pertechnetate. The labeled complex and Tc-99m-hydrolyzate was separated by using ascending paper (Schleicher and Schull) chromatography and 1N NaCl as the mobile phase. Reliable results were obtained showing that the content of the impurities Tc-99m-pertechnetate and Tc-99m-hydrolyzate is 1.7+/-1.3% and 3.4+/-2.1%, respectively. The biodistribution depends on the quantity of DPD. For the animal experiments its content should be 70-80 mu g/kg b.w. The experiments revealed that the mean value of bone distribution was 8.8+/-1.9%/g and in muscles 0.043+/-0.042%/g. The uptake in liver and kidneys was below 3%, i.e., 0.65+/-0.29 and 1.71+/-0.68%/organ, respectively. The bone/muscle ratio shoul...d be at least 160. The analysis shows that the obtained values are arranged around their, statistically allowed, mean values.
Извор:
Journal of Radioanalytical and Nuclear Chemistry, 2000, 243, 3, 669-671
DOI: 10.1023/A:1010614101992
ISSN: 0236-5731
WoS: 000088410200012
Scopus: 2-s2.0-0343627891
Колекције
Институција/група
VinčaTY - JOUR AU - Maksin, Tatjana N. AU - Vučina, Jurij L. AU - Đokić, Divna Đ. AU - Janković, Drina PY - 2000 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2363 AB - The results of the quality control of Tc-99m-DPD produced during five consequtive years are statistically evaluated. Radiochemical purity of the kit determined in 75 batches was 98.3+/-1.3%. TLC on silica gel with the mixture of acetone and methanole (1:1, v/v) was used to determine the content of free pertechnetate. The labeled complex and Tc-99m-hydrolyzate was separated by using ascending paper (Schleicher and Schull) chromatography and 1N NaCl as the mobile phase. Reliable results were obtained showing that the content of the impurities Tc-99m-pertechnetate and Tc-99m-hydrolyzate is 1.7+/-1.3% and 3.4+/-2.1%, respectively. The biodistribution depends on the quantity of DPD. For the animal experiments its content should be 70-80 mu g/kg b.w. The experiments revealed that the mean value of bone distribution was 8.8+/-1.9%/g and in muscles 0.043+/-0.042%/g. The uptake in liver and kidneys was below 3%, i.e., 0.65+/-0.29 and 1.71+/-0.68%/organ, respectively. The bone/muscle ratio should be at least 160. The analysis shows that the obtained values are arranged around their, statistically allowed, mean values. T2 - Journal of Radioanalytical and Nuclear Chemistry T1 - Statistical evaluation of the quality control results of Tc-99m(Sn)-DPD VL - 243 IS - 3 SP - 669 EP - 671 DO - 10.1023/A:1010614101992 ER -
@article{ author = "Maksin, Tatjana N. and Vučina, Jurij L. and Đokić, Divna Đ. and Janković, Drina", year = "2000", abstract = "The results of the quality control of Tc-99m-DPD produced during five consequtive years are statistically evaluated. Radiochemical purity of the kit determined in 75 batches was 98.3+/-1.3%. TLC on silica gel with the mixture of acetone and methanole (1:1, v/v) was used to determine the content of free pertechnetate. The labeled complex and Tc-99m-hydrolyzate was separated by using ascending paper (Schleicher and Schull) chromatography and 1N NaCl as the mobile phase. Reliable results were obtained showing that the content of the impurities Tc-99m-pertechnetate and Tc-99m-hydrolyzate is 1.7+/-1.3% and 3.4+/-2.1%, respectively. The biodistribution depends on the quantity of DPD. For the animal experiments its content should be 70-80 mu g/kg b.w. The experiments revealed that the mean value of bone distribution was 8.8+/-1.9%/g and in muscles 0.043+/-0.042%/g. The uptake in liver and kidneys was below 3%, i.e., 0.65+/-0.29 and 1.71+/-0.68%/organ, respectively. The bone/muscle ratio should be at least 160. The analysis shows that the obtained values are arranged around their, statistically allowed, mean values.", journal = "Journal of Radioanalytical and Nuclear Chemistry", title = "Statistical evaluation of the quality control results of Tc-99m(Sn)-DPD", volume = "243", number = "3", pages = "669-671", doi = "10.1023/A:1010614101992" }
Maksin, T. N., Vučina, J. L., Đokić, D. Đ.,& Janković, D.. (2000). Statistical evaluation of the quality control results of Tc-99m(Sn)-DPD. in Journal of Radioanalytical and Nuclear Chemistry, 243(3), 669-671. https://doi.org/10.1023/A:1010614101992
Maksin TN, Vučina JL, Đokić DĐ, Janković D. Statistical evaluation of the quality control results of Tc-99m(Sn)-DPD. in Journal of Radioanalytical and Nuclear Chemistry. 2000;243(3):669-671. doi:10.1023/A:1010614101992 .
Maksin, Tatjana N., Vučina, Jurij L., Đokić, Divna Đ., Janković, Drina, "Statistical evaluation of the quality control results of Tc-99m(Sn)-DPD" in Journal of Radioanalytical and Nuclear Chemistry, 243, no. 3 (2000):669-671, https://doi.org/10.1023/A:1010614101992 . .