Gas chromatography mass spectrometry study of isosorbide 5-mononitrate stability
Authorized Users Only
1996
Authors
Marinković, Valentina D.Gudžić, Branislav T.
Milojković, Smiljana S.
Nedeljković, Jovan
Čomor, Jožef J.
Article (Published version)
Metadata
Show full item recordAbstract
The stability of isosorbide 5-mononitrate (5-ISMN) was investigated at 40 degrees C under dry and wet air (75% relative humidity). The degradation products were identified and quantified by means of capillary GC-MS preceded by drying and silylation of the samples. The only degradation products identified were the two diastereoisomers of isosorbide. From the initial slope of degradation curves the maximal degradation rates were estimated to be 0.17 and 2.44% year(-1) under dry and wet conditions, respectively.
Keywords:
pharmaceutical analysis / stability studies / isosorbide / isosorbide mononitrateSource:
Journal of Chromatography A, 1996, 746, 2, 286-288
DOI: 10.1016/0021-9673(96)00296-8
ISSN: 0021-9673
WoS: A1996VQ49900016
Scopus: 2-s2.0-0030580145
Institution/Community
VinčaTY - JOUR AU - Marinković, Valentina D. AU - Gudžić, Branislav T. AU - Milojković, Smiljana S. AU - Nedeljković, Jovan AU - Čomor, Jožef J. PY - 1996 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2020 AB - The stability of isosorbide 5-mononitrate (5-ISMN) was investigated at 40 degrees C under dry and wet air (75% relative humidity). The degradation products were identified and quantified by means of capillary GC-MS preceded by drying and silylation of the samples. The only degradation products identified were the two diastereoisomers of isosorbide. From the initial slope of degradation curves the maximal degradation rates were estimated to be 0.17 and 2.44% year(-1) under dry and wet conditions, respectively. T2 - Journal of Chromatography A T1 - Gas chromatography mass spectrometry study of isosorbide 5-mononitrate stability VL - 746 IS - 2 SP - 286 EP - 288 DO - 10.1016/0021-9673(96)00296-8 ER -
@article{ author = "Marinković, Valentina D. and Gudžić, Branislav T. and Milojković, Smiljana S. and Nedeljković, Jovan and Čomor, Jožef J.", year = "1996", abstract = "The stability of isosorbide 5-mononitrate (5-ISMN) was investigated at 40 degrees C under dry and wet air (75% relative humidity). The degradation products were identified and quantified by means of capillary GC-MS preceded by drying and silylation of the samples. The only degradation products identified were the two diastereoisomers of isosorbide. From the initial slope of degradation curves the maximal degradation rates were estimated to be 0.17 and 2.44% year(-1) under dry and wet conditions, respectively.", journal = "Journal of Chromatography A", title = "Gas chromatography mass spectrometry study of isosorbide 5-mononitrate stability", volume = "746", number = "2", pages = "286-288", doi = "10.1016/0021-9673(96)00296-8" }
Marinković, V. D., Gudžić, B. T., Milojković, S. S., Nedeljković, J.,& Čomor, J. J.. (1996). Gas chromatography mass spectrometry study of isosorbide 5-mononitrate stability. in Journal of Chromatography A, 746(2), 286-288. https://doi.org/10.1016/0021-9673(96)00296-8
Marinković VD, Gudžić BT, Milojković SS, Nedeljković J, Čomor JJ. Gas chromatography mass spectrometry study of isosorbide 5-mononitrate stability. in Journal of Chromatography A. 1996;746(2):286-288. doi:10.1016/0021-9673(96)00296-8 .
Marinković, Valentina D., Gudžić, Branislav T., Milojković, Smiljana S., Nedeljković, Jovan, Čomor, Jožef J., "Gas chromatography mass spectrometry study of isosorbide 5-mononitrate stability" in Journal of Chromatography A, 746, no. 2 (1996):286-288, https://doi.org/10.1016/0021-9673(96)00296-8 . .