Determination of Enalapril in Pharmaceuticals using Electrochemical Sensing with Amperometric Detection
Apstrakt
In this work a new electrochemical method will be presented for the determination of enalapril in pharmaceutical tablets using unmodified screen printed electrode (SPE). The studies were done using amperommetric detection. Enalapril provides well defined, ovalshape oxidation peak at +1.05 V (vs. Ag/AgCl, 3.0 M KCl) in Britton-Robinson buffer solution (BRBS) at pH 5.0. After optimization of the experimental conditions, the influence of most common interferent compounds was tested. Under optimized experimental conditions, the signals were linearly proportional to the concentration of enalapril in the range from 2.5 to 90 mu M with a detection limit of 0.9 mu M. Repeatability of ten replicate measurements of 5 mu M enalapril was estimated to be 1.5%. Proposed method was successfully applied for the determination of the total amount of enalapril content in pharmaceutical preparations. Nevertheless, proposed method could be beneficial for the quick quantifications of enalapril in drugs usin...g unmodified SPE electrode without any further treatment.
Ključne reči:
Enalapril / Pharmaceutical tablets / Screen printed electrode / AmperometryIzvor:
Analytical and Bioanalytical Electrochemistry, 2017, 9, 8, 1000-1007Finansiranje / projekti:
- Primena unapređenih oksidacionih procesa i nanostrukturisanih oksidnih materijala za uklanjanje zagađivača iz životne sredine, razvoj i optimizacija instrumentalnih tehnika za praćenje efikasnosti (RS-MESTD-Basic Research (BR or ON)-172030)
- HigherKOS Stipendien program in Austria
- Strengthening of the MagBioVin Research and Innovation Team for Development of Novel Approaches for Tumour Therapy based on Nanostructured Materials (EU-FP7-621375)
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Mehmeti, Eda AU - Stanković, Dalibor M. AU - Kalcher, Kurt PY - 2017 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1892 AB - In this work a new electrochemical method will be presented for the determination of enalapril in pharmaceutical tablets using unmodified screen printed electrode (SPE). The studies were done using amperommetric detection. Enalapril provides well defined, ovalshape oxidation peak at +1.05 V (vs. Ag/AgCl, 3.0 M KCl) in Britton-Robinson buffer solution (BRBS) at pH 5.0. After optimization of the experimental conditions, the influence of most common interferent compounds was tested. Under optimized experimental conditions, the signals were linearly proportional to the concentration of enalapril in the range from 2.5 to 90 mu M with a detection limit of 0.9 mu M. Repeatability of ten replicate measurements of 5 mu M enalapril was estimated to be 1.5%. Proposed method was successfully applied for the determination of the total amount of enalapril content in pharmaceutical preparations. Nevertheless, proposed method could be beneficial for the quick quantifications of enalapril in drugs using unmodified SPE electrode without any further treatment. T2 - Analytical and Bioanalytical Electrochemistry T1 - Determination of Enalapril in Pharmaceuticals using Electrochemical Sensing with Amperometric Detection VL - 9 IS - 8 SP - 1000 EP - 1007 UR - https://hdl.handle.net/21.15107/rcub_vinar_1892 ER -
@article{ author = "Mehmeti, Eda and Stanković, Dalibor M. and Kalcher, Kurt", year = "2017", abstract = "In this work a new electrochemical method will be presented for the determination of enalapril in pharmaceutical tablets using unmodified screen printed electrode (SPE). The studies were done using amperommetric detection. Enalapril provides well defined, ovalshape oxidation peak at +1.05 V (vs. Ag/AgCl, 3.0 M KCl) in Britton-Robinson buffer solution (BRBS) at pH 5.0. After optimization of the experimental conditions, the influence of most common interferent compounds was tested. Under optimized experimental conditions, the signals were linearly proportional to the concentration of enalapril in the range from 2.5 to 90 mu M with a detection limit of 0.9 mu M. Repeatability of ten replicate measurements of 5 mu M enalapril was estimated to be 1.5%. Proposed method was successfully applied for the determination of the total amount of enalapril content in pharmaceutical preparations. Nevertheless, proposed method could be beneficial for the quick quantifications of enalapril in drugs using unmodified SPE electrode without any further treatment.", journal = "Analytical and Bioanalytical Electrochemistry", title = "Determination of Enalapril in Pharmaceuticals using Electrochemical Sensing with Amperometric Detection", volume = "9", number = "8", pages = "1000-1007", url = "https://hdl.handle.net/21.15107/rcub_vinar_1892" }
Mehmeti, E., Stanković, D. M.,& Kalcher, K.. (2017). Determination of Enalapril in Pharmaceuticals using Electrochemical Sensing with Amperometric Detection. in Analytical and Bioanalytical Electrochemistry, 9(8), 1000-1007. https://hdl.handle.net/21.15107/rcub_vinar_1892
Mehmeti E, Stanković DM, Kalcher K. Determination of Enalapril in Pharmaceuticals using Electrochemical Sensing with Amperometric Detection. in Analytical and Bioanalytical Electrochemistry. 2017;9(8):1000-1007. https://hdl.handle.net/21.15107/rcub_vinar_1892 .
Mehmeti, Eda, Stanković, Dalibor M., Kalcher, Kurt, "Determination of Enalapril in Pharmaceuticals using Electrochemical Sensing with Amperometric Detection" in Analytical and Bioanalytical Electrochemistry, 9, no. 8 (2017):1000-1007, https://hdl.handle.net/21.15107/rcub_vinar_1892 .