Mechanisms of redox interactions of bilirubin with copper and the effects of penicillamine
Samo za registrovane korisnike
2017
Autori
Božić, BojanaKorać, Jelena
Stanković, Dalibor M.
Stanić, Marina
Popović-Bijelić, Ana D.
Bogdanović-Pristov, Jelena
Spasojević, Ivan
Bajčetić, Milica
Članak u časopisu (Objavljena verzija)
,
© 2017 Elsevier B.V.
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Toxic effects of unconjugated bilirubin (BR) in neonatal hyperbilirubinemia have been related to redox and/or coordinate interactions with Cu2+. However, the development and mechanisms of such interactions at physiological pH have not been resolved. This study shows that BR reduces Cu2+ to Cu1+ in 1:1 stoichiometry. Apparently, BR undergoes degradation, i.e. BR and Cu2+ do not form stable complexes. The binding of Cu2+ to inorganic phosphates, liposomal phosphate groups, or to chelating drug penicillamine, impedes redox interactions with BR. Cu1+ undergoes spontaneous oxidation by O-2 resulting in hydrogen peroxide accumulation and hydroxyl radical production. In relation to this, copper and BR induced synergistic oxidative/damaging effects on erythrocytes membrane, which were alleviated by penicillamine. The production of reactive oxygen species by BR and copper represents a plausible cause of BR toxic effects and cell damage in hyperbilirubinemia. Further examination of therapeutic p...otentials of copper chelators in the treatment of severe neonatal hyperbilirubinemia is needed.
Ključne reči:
Erythrocytes / Hydrogen peroxide / Hyperbilirubinemia / Lipid peroxidation / SuperoxideIzvor:
Chemico-Biological Interactions, 2017, 278, 129-134Finansiranje / projekti:
- Molekularni mehanizmi redoks signalinga u homeostazi, adaptaciji i patologiji (RS-MESTD-Basic Research (BR or ON)-173014)
- Ispitivanja odnosa struktura-funkcija u ćelijskom zidu biljaka i izmene strukture zida enzimskim inženjeringom (RS-MESTD-Basic Research (BR or ON)-173017)
- Strengthening of the MagBioVin Research and Innovation Team for Development of Novel Approaches for Tumour Therapy based on Nanostructured Materials (EU-FP7-621375)
DOI: 10.1016/j.cbi.2017.10.022
ISSN: 0009-2797
PubMed: 29079291
WoS: 000418302000016
Scopus: 2-s2.0-85032258652
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Božić, Bojana AU - Korać, Jelena AU - Stanković, Dalibor M. AU - Stanić, Marina AU - Popović-Bijelić, Ana D. AU - Bogdanović-Pristov, Jelena AU - Spasojević, Ivan AU - Bajčetić, Milica PY - 2017 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1878 AB - Toxic effects of unconjugated bilirubin (BR) in neonatal hyperbilirubinemia have been related to redox and/or coordinate interactions with Cu2+. However, the development and mechanisms of such interactions at physiological pH have not been resolved. This study shows that BR reduces Cu2+ to Cu1+ in 1:1 stoichiometry. Apparently, BR undergoes degradation, i.e. BR and Cu2+ do not form stable complexes. The binding of Cu2+ to inorganic phosphates, liposomal phosphate groups, or to chelating drug penicillamine, impedes redox interactions with BR. Cu1+ undergoes spontaneous oxidation by O-2 resulting in hydrogen peroxide accumulation and hydroxyl radical production. In relation to this, copper and BR induced synergistic oxidative/damaging effects on erythrocytes membrane, which were alleviated by penicillamine. The production of reactive oxygen species by BR and copper represents a plausible cause of BR toxic effects and cell damage in hyperbilirubinemia. Further examination of therapeutic potentials of copper chelators in the treatment of severe neonatal hyperbilirubinemia is needed. T2 - Chemico-Biological Interactions T1 - Mechanisms of redox interactions of bilirubin with copper and the effects of penicillamine VL - 278 SP - 129 EP - 134 DO - 10.1016/j.cbi.2017.10.022 ER -
@article{ author = "Božić, Bojana and Korać, Jelena and Stanković, Dalibor M. and Stanić, Marina and Popović-Bijelić, Ana D. and Bogdanović-Pristov, Jelena and Spasojević, Ivan and Bajčetić, Milica", year = "2017", abstract = "Toxic effects of unconjugated bilirubin (BR) in neonatal hyperbilirubinemia have been related to redox and/or coordinate interactions with Cu2+. However, the development and mechanisms of such interactions at physiological pH have not been resolved. This study shows that BR reduces Cu2+ to Cu1+ in 1:1 stoichiometry. Apparently, BR undergoes degradation, i.e. BR and Cu2+ do not form stable complexes. The binding of Cu2+ to inorganic phosphates, liposomal phosphate groups, or to chelating drug penicillamine, impedes redox interactions with BR. Cu1+ undergoes spontaneous oxidation by O-2 resulting in hydrogen peroxide accumulation and hydroxyl radical production. In relation to this, copper and BR induced synergistic oxidative/damaging effects on erythrocytes membrane, which were alleviated by penicillamine. The production of reactive oxygen species by BR and copper represents a plausible cause of BR toxic effects and cell damage in hyperbilirubinemia. Further examination of therapeutic potentials of copper chelators in the treatment of severe neonatal hyperbilirubinemia is needed.", journal = "Chemico-Biological Interactions", title = "Mechanisms of redox interactions of bilirubin with copper and the effects of penicillamine", volume = "278", pages = "129-134", doi = "10.1016/j.cbi.2017.10.022" }
Božić, B., Korać, J., Stanković, D. M., Stanić, M., Popović-Bijelić, A. D., Bogdanović-Pristov, J., Spasojević, I.,& Bajčetić, M.. (2017). Mechanisms of redox interactions of bilirubin with copper and the effects of penicillamine. in Chemico-Biological Interactions, 278, 129-134. https://doi.org/10.1016/j.cbi.2017.10.022
Božić B, Korać J, Stanković DM, Stanić M, Popović-Bijelić AD, Bogdanović-Pristov J, Spasojević I, Bajčetić M. Mechanisms of redox interactions of bilirubin with copper and the effects of penicillamine. in Chemico-Biological Interactions. 2017;278:129-134. doi:10.1016/j.cbi.2017.10.022 .
Božić, Bojana, Korać, Jelena, Stanković, Dalibor M., Stanić, Marina, Popović-Bijelić, Ana D., Bogdanović-Pristov, Jelena, Spasojević, Ivan, Bajčetić, Milica, "Mechanisms of redox interactions of bilirubin with copper and the effects of penicillamine" in Chemico-Biological Interactions, 278 (2017):129-134, https://doi.org/10.1016/j.cbi.2017.10.022 . .