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Cytotoxic and Antimicrobial Activity of Dehydrozingerone based Cyclopropyl Derivatives
dc.creator | Burmudžija, Adrijana Z. | |
dc.creator | Muškinja, Jovana | |
dc.creator | Kosanić, Marijana | |
dc.creator | Ranković, Branislav | |
dc.creator | Novaković, Slađana B. | |
dc.creator | Đorđević, Snežana | |
dc.creator | Stanojković, Tatjana P. | |
dc.creator | Baskić, Dejan D. | |
dc.creator | Ratković, Zoran R. | |
dc.date.accessioned | 2018-03-01T17:46:41Z | |
dc.date.available | 2018-03-01T17:46:41Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1612-1872 | |
dc.identifier.issn | 1612-1880 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/1680 | |
dc.description.abstract | A small series of 1-acetyl-2-(4-alkoxy-3-methoxyphenyl)cyclopropanes was prepared, starting from dehydrozingerone (4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-one) and its O-alkyl derivatives. Their microbiological activities toward some strains of bacteria and fungi were tested, as well as their in vitro cytotoxic activity against some cancer cell lines (HeLa, LS174 and A549). All synthesized compounds showed significant antimicrobial activity and expressed cytotoxic activity against tested carcinoma cell lines, but they showed no significant influence on normal cell line (MRC5). Butyl derivative is the most active on HeLa cells (IC50 = 8.63 m), while benzyl one is active against LS174 and A549 cell lines (IC50 = 10.17 and 12.15 m, respectively). | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172034/RS// | |
dc.rights | restrictedAccess | en |
dc.source | Chemistry and Biodiversity | en |
dc.subject | Cytotoxic activities | en |
dc.subject | Antimicrobial activities | en |
dc.subject | Dehydrozingerone | en |
dc.subject | Cyclopropyl moiety | en |
dc.subject | Crystal structure elucidation | en |
dc.title | Cytotoxic and Antimicrobial Activity of Dehydrozingerone based Cyclopropyl Derivatives | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Ранковиц, Бранислав Р.; Новаковић Слађана; Станојковиц, Татјана П.; Баскиц, Дејан Д.; Дордевиц, Снезана Б.; Косаниц, Маријана М.; Ратковиц, Зоран Р.; Мускиња, Јована М.; Бурмудзија, Aдријана З.; | |
dc.citation.volume | 14 | |
dc.citation.issue | 8 | |
dc.identifier.wos | 000407608400008 | |
dc.identifier.doi | 10.1002/cbdv.201700077 | |
dc.citation.other | Article Number: e1700077 | |
dc.citation.rank | M22 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85021654218 |
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020 - Laboratorija za teorijsku fiziku i fiziku kondenzovane materije
Department of Theoretical Physics and Condensed Matter Physics