Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination
Apstrakt
A simple and fast method for determination of two phenothiazine drugs, chlorpromazine (CPZ) and thioridazine (TDZ), at the boron-doped diamond electrode (BDDE) was proposed. Oxidation peaks on potentials higher than 1 V were used for quantitation of investigated phenothiazines due to better selectivity over common interfering compounds in urine. Differential pulse voltammetry was applied for trace determination of CPZ and TDZ, in Britton-Robinson buffer solution at optimal pH. Under optimized DPV conditions a linear analytical curve was obtained from 1.0x10(-7) to 4.0x10(-5) M with a detection limit of 0.3x10(-7) M (for CPZ) and in the concentration range of 2x10(-7) M to 4.0x10(-5) M, with a detection limit of 1.2x10(-7)M (for TDZ). The applicability of the method was proved by determination of CPZ and TDZ by proposed procedures in spiked urine samples. The electrochemical behavior of those two important tranquilizers in different solvents was described, exploring the possibility of s...imultaneous determination.
Ključne reči:
voltammetric method / chlorpromazine / thioridazine / boron-doped diamond electrode / human urineIzvor:
International Journal of Electrochemical Science, 2017, 12, 5, 3709-3720Finansiranje / projekti:
- Višeskalno strukturiranje polimernih nanokompozita i funkcionalnih materijala primenom različitih prekursora (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45022)
- Primena unapređenih oksidacionih procesa i nanostrukturisanih oksidnih materijala za uklanjanje zagađivača iz životne sredine, razvoj i optimizacija instrumentalnih tehnika za praćenje efikasnosti (RS-MESTD-Basic Research (BR or ON)-172030)
- Strengthening of the MagBioVin Research and Innovation Team for Development of Novel Approaches for Tumour Therapy based on Nanostructured Materials (EU-FP7-621375)
DOI: 10.20964/2017.05.34
ISSN: 1452-3981
WoS: 000402485100013
Scopus: 2-s2.0-85019613952
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Petković, Branka B. AU - Kuzmanović, D. AU - Dimitrijević, T. AU - Krstić, Milena P. AU - Stanković, Dalibor M. PY - 2017 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1596 AB - A simple and fast method for determination of two phenothiazine drugs, chlorpromazine (CPZ) and thioridazine (TDZ), at the boron-doped diamond electrode (BDDE) was proposed. Oxidation peaks on potentials higher than 1 V were used for quantitation of investigated phenothiazines due to better selectivity over common interfering compounds in urine. Differential pulse voltammetry was applied for trace determination of CPZ and TDZ, in Britton-Robinson buffer solution at optimal pH. Under optimized DPV conditions a linear analytical curve was obtained from 1.0x10(-7) to 4.0x10(-5) M with a detection limit of 0.3x10(-7) M (for CPZ) and in the concentration range of 2x10(-7) M to 4.0x10(-5) M, with a detection limit of 1.2x10(-7)M (for TDZ). The applicability of the method was proved by determination of CPZ and TDZ by proposed procedures in spiked urine samples. The electrochemical behavior of those two important tranquilizers in different solvents was described, exploring the possibility of simultaneous determination. T2 - International Journal of Electrochemical Science T1 - Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination VL - 12 IS - 5 SP - 3709 EP - 3720 DO - 10.20964/2017.05.34 ER -
@article{ author = "Petković, Branka B. and Kuzmanović, D. and Dimitrijević, T. and Krstić, Milena P. and Stanković, Dalibor M.", year = "2017", abstract = "A simple and fast method for determination of two phenothiazine drugs, chlorpromazine (CPZ) and thioridazine (TDZ), at the boron-doped diamond electrode (BDDE) was proposed. Oxidation peaks on potentials higher than 1 V were used for quantitation of investigated phenothiazines due to better selectivity over common interfering compounds in urine. Differential pulse voltammetry was applied for trace determination of CPZ and TDZ, in Britton-Robinson buffer solution at optimal pH. Under optimized DPV conditions a linear analytical curve was obtained from 1.0x10(-7) to 4.0x10(-5) M with a detection limit of 0.3x10(-7) M (for CPZ) and in the concentration range of 2x10(-7) M to 4.0x10(-5) M, with a detection limit of 1.2x10(-7)M (for TDZ). The applicability of the method was proved by determination of CPZ and TDZ by proposed procedures in spiked urine samples. The electrochemical behavior of those two important tranquilizers in different solvents was described, exploring the possibility of simultaneous determination.", journal = "International Journal of Electrochemical Science", title = "Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination", volume = "12", number = "5", pages = "3709-3720", doi = "10.20964/2017.05.34" }
Petković, B. B., Kuzmanović, D., Dimitrijević, T., Krstić, M. P.,& Stanković, D. M.. (2017). Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination. in International Journal of Electrochemical Science, 12(5), 3709-3720. https://doi.org/10.20964/2017.05.34
Petković BB, Kuzmanović D, Dimitrijević T, Krstić MP, Stanković DM. Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination. in International Journal of Electrochemical Science. 2017;12(5):3709-3720. doi:10.20964/2017.05.34 .
Petković, Branka B., Kuzmanović, D., Dimitrijević, T., Krstić, Milena P., Stanković, Dalibor M., "Novel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determination" in International Journal of Electrochemical Science, 12, no. 5 (2017):3709-3720, https://doi.org/10.20964/2017.05.34 . .