Mercury-free and modification-free electroanalytical approach towards bromazepam and alprazolam sensing: A facile and efficient assay for their quantification in pharmaceuticals using boron-doped diamond electrodes
Samo za registrovane korisnike
2017
Autori
Samiec, PetrŠvorc, Lubomir
Stanković, Dalibor M.
Vojs, Marian
Marton, Marian
Navratilova, Zuzana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The boron-doped diamond electrodes (BDDEs) with different dopant levels were applied as advanced, mercury-free and modification-free electroanalytical platforms for simple and reliable quantification of benzodiazepines, bromazepam (BZ) and alprazolam (ALZ). Cyclic voltammetric measurements revealed that the electrode reactions of both analytes were manifested by one irreversible and diffusion-controlled reduction peak at -1.10V in Britton-Robinson buffer of pH 11 for BZ using lab-made BDDE with 1000 ppm B/C ratio and -0.84V in BR buffer of pH 5 for ALZ using commercial BDDE with 1000 ppm B/C ratio. Differential pulse voltammetry was used for construction of calibration curves for BZ and ALZ, respectively, with the analytical parameters as follows: the linear dynamic ranges of 1 x 10(-6)-1 x 10(-4) and 8 x 10(-7)-1 x 10(-4) mol/L, the detection limit of 3.1 x 10(-7) and 6.4 x 10(-7) mol/L and the excellent repeatability with the relative standard deviation below 3% for both drugs. The d...eveloped methods were applied to analysis of the pharmaceutical tablets with the recoveries from 97.33 to 100.85% for BZ and from 94.14 to 101.32% for ALZ. The usage of BDDEs as advanced electrochemical sensors in drug analysis represents a facile and effective analytical approach which may replace mercury-based sensors and chemically modified electrodes in previous benzodiazepines sensing. (C) 2017 Elsevier B.V. All rights reserved.
Ključne reči:
Benzodiazepines / Boron-doped diamond electrode / Electrochemical sensor / Differential pulse voltammetry / Pharmaceutical tabletIzvor:
Sensors and Actuators B: Chemical, 2017, 245, 963-971Finansiranje / projekti:
- Primena unapređenih oksidacionih procesa i nanostrukturisanih oksidnih materijala za uklanjanje zagađivača iz životne sredine, razvoj i optimizacija instrumentalnih tehnika za praćenje efikasnosti (RS-MESTD-Basic Research (BR or ON)-172030)
- Student grant competition (University of Ostrava) [SGS07/PrF/2015]
- Student grant competition (University of Ostrava) [SGS03/PrF/2016]
- Grant Agency of the Slovak Republic [1/0489/16]
- Slovak Research and Development Agency [APVV-0365-12]
- Strengthening of the MagBioVin Research and Innovation Team for Development of Novel Approaches for Tumour Therapy based on Nanostructured Materials (EU-FP7-621375)
- STU Grant scheme
Napomena:
- Peer-reviewed version of the article (Accepted Manuscript or postprint) available at: https://vinar.vin.bg.ac.rs/handle/123456789/8853
DOI: 10.1016/j.snb.2017.02.023
ISSN: 0925-4005
WoS: 000398760700113
Scopus: 2-s2.0-85013001578
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Samiec, Petr AU - Švorc, Lubomir AU - Stanković, Dalibor M. AU - Vojs, Marian AU - Marton, Marian AU - Navratilova, Zuzana PY - 2017 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1504 AB - The boron-doped diamond electrodes (BDDEs) with different dopant levels were applied as advanced, mercury-free and modification-free electroanalytical platforms for simple and reliable quantification of benzodiazepines, bromazepam (BZ) and alprazolam (ALZ). Cyclic voltammetric measurements revealed that the electrode reactions of both analytes were manifested by one irreversible and diffusion-controlled reduction peak at -1.10V in Britton-Robinson buffer of pH 11 for BZ using lab-made BDDE with 1000 ppm B/C ratio and -0.84V in BR buffer of pH 5 for ALZ using commercial BDDE with 1000 ppm B/C ratio. Differential pulse voltammetry was used for construction of calibration curves for BZ and ALZ, respectively, with the analytical parameters as follows: the linear dynamic ranges of 1 x 10(-6)-1 x 10(-4) and 8 x 10(-7)-1 x 10(-4) mol/L, the detection limit of 3.1 x 10(-7) and 6.4 x 10(-7) mol/L and the excellent repeatability with the relative standard deviation below 3% for both drugs. The developed methods were applied to analysis of the pharmaceutical tablets with the recoveries from 97.33 to 100.85% for BZ and from 94.14 to 101.32% for ALZ. The usage of BDDEs as advanced electrochemical sensors in drug analysis represents a facile and effective analytical approach which may replace mercury-based sensors and chemically modified electrodes in previous benzodiazepines sensing. (C) 2017 Elsevier B.V. All rights reserved. T2 - Sensors and Actuators B: Chemical T1 - Mercury-free and modification-free electroanalytical approach towards bromazepam and alprazolam sensing: A facile and efficient assay for their quantification in pharmaceuticals using boron-doped diamond electrodes VL - 245 SP - 963 EP - 971 DO - 10.1016/j.snb.2017.02.023 ER -
@article{ author = "Samiec, Petr and Švorc, Lubomir and Stanković, Dalibor M. and Vojs, Marian and Marton, Marian and Navratilova, Zuzana", year = "2017", abstract = "The boron-doped diamond electrodes (BDDEs) with different dopant levels were applied as advanced, mercury-free and modification-free electroanalytical platforms for simple and reliable quantification of benzodiazepines, bromazepam (BZ) and alprazolam (ALZ). Cyclic voltammetric measurements revealed that the electrode reactions of both analytes were manifested by one irreversible and diffusion-controlled reduction peak at -1.10V in Britton-Robinson buffer of pH 11 for BZ using lab-made BDDE with 1000 ppm B/C ratio and -0.84V in BR buffer of pH 5 for ALZ using commercial BDDE with 1000 ppm B/C ratio. Differential pulse voltammetry was used for construction of calibration curves for BZ and ALZ, respectively, with the analytical parameters as follows: the linear dynamic ranges of 1 x 10(-6)-1 x 10(-4) and 8 x 10(-7)-1 x 10(-4) mol/L, the detection limit of 3.1 x 10(-7) and 6.4 x 10(-7) mol/L and the excellent repeatability with the relative standard deviation below 3% for both drugs. The developed methods were applied to analysis of the pharmaceutical tablets with the recoveries from 97.33 to 100.85% for BZ and from 94.14 to 101.32% for ALZ. The usage of BDDEs as advanced electrochemical sensors in drug analysis represents a facile and effective analytical approach which may replace mercury-based sensors and chemically modified electrodes in previous benzodiazepines sensing. (C) 2017 Elsevier B.V. All rights reserved.", journal = "Sensors and Actuators B: Chemical", title = "Mercury-free and modification-free electroanalytical approach towards bromazepam and alprazolam sensing: A facile and efficient assay for their quantification in pharmaceuticals using boron-doped diamond electrodes", volume = "245", pages = "963-971", doi = "10.1016/j.snb.2017.02.023" }
Samiec, P., Švorc, L., Stanković, D. M., Vojs, M., Marton, M.,& Navratilova, Z.. (2017). Mercury-free and modification-free electroanalytical approach towards bromazepam and alprazolam sensing: A facile and efficient assay for their quantification in pharmaceuticals using boron-doped diamond electrodes. in Sensors and Actuators B: Chemical, 245, 963-971. https://doi.org/10.1016/j.snb.2017.02.023
Samiec P, Švorc L, Stanković DM, Vojs M, Marton M, Navratilova Z. Mercury-free and modification-free electroanalytical approach towards bromazepam and alprazolam sensing: A facile and efficient assay for their quantification in pharmaceuticals using boron-doped diamond electrodes. in Sensors and Actuators B: Chemical. 2017;245:963-971. doi:10.1016/j.snb.2017.02.023 .
Samiec, Petr, Švorc, Lubomir, Stanković, Dalibor M., Vojs, Marian, Marton, Marian, Navratilova, Zuzana, "Mercury-free and modification-free electroanalytical approach towards bromazepam and alprazolam sensing: A facile and efficient assay for their quantification in pharmaceuticals using boron-doped diamond electrodes" in Sensors and Actuators B: Chemical, 245 (2017):963-971, https://doi.org/10.1016/j.snb.2017.02.023 . .