Carvacrol-loaded premixed calcium phosphate bone cements with exceptional osteogenic and antibacterial properties to heal infected bone defects
Samo za registrovane korisnike
2024
Autori
Cui, ChenLiu, Dachuan
Xie, Xiaobin
Wang, Lijie
Lukić, Miodrag J.
Qiu, Xubin
Chen, Weicheng
Shi, Jiaxu
Hong, Youzhi
Li, Bin
Liu, Zhiwei
Chen, Song
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The healing of infected bone fractures represents a significant clinical challenge in orthopedic surgery. Calcium phosphate cements (CPCs) are attractive materials, highly applicable in bone healing due to their satisfactory biological properties and chemical similarity to bone minerals. However, manual mixing is often required before localized application of conventional CPCs, increasing the risk of infection. Moreover, their antibacterial properties are often insufficient for treating infected fractures. In this study, antimicrobial two-paste premixed CPCs loaded with carvacrol were developed. The influence of the carvacrol on the setting properties and mechanical strength of the cement was studied. In vitro studies demonstrated the biocompatibility, osteogenic potential, and broad-spectrum antimicrobial efficacy of the premixed bone cements, including effectiveness against gram-positive, gram-negative, and drug-resistant bacteria. Notably, in vivo studies revealed exceptional antimi...crobial and osteogenic properties of the carvacrol-loaded cements, confirming the promising potential of the premixed cements for the healing of infected bone defects.
Ključne reči:
Calcium phosphate / Premixed bone cement / Bone repair / CarvacrolIzvor:
Composites Part B: Engineering, 2024, 287, 111812-Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200017 (Univerzitet u Beogradu, Institut za nuklearne nauke Vinča, Beograd-Vinča) (RS-MESTD-inst-2020-200017)
- National Key R&D Program of China [2023YFB3810201]
- National Natural Science Foundation of China [32271421, 81925027]
DOI: 10.1016/j.compositesb.2024.111812
ISSN: 1359-8368
Scopus: 2-s2.0-85203198249
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Cui, Chen AU - Liu, Dachuan AU - Xie, Xiaobin AU - Wang, Lijie AU - Lukić, Miodrag J. AU - Qiu, Xubin AU - Chen, Weicheng AU - Shi, Jiaxu AU - Hong, Youzhi AU - Li, Bin AU - Liu, Zhiwei AU - Chen, Song PY - 2024 UR - https://vinar.vin.bg.ac.rs/handle/123456789/13729 AB - The healing of infected bone fractures represents a significant clinical challenge in orthopedic surgery. Calcium phosphate cements (CPCs) are attractive materials, highly applicable in bone healing due to their satisfactory biological properties and chemical similarity to bone minerals. However, manual mixing is often required before localized application of conventional CPCs, increasing the risk of infection. Moreover, their antibacterial properties are often insufficient for treating infected fractures. In this study, antimicrobial two-paste premixed CPCs loaded with carvacrol were developed. The influence of the carvacrol on the setting properties and mechanical strength of the cement was studied. In vitro studies demonstrated the biocompatibility, osteogenic potential, and broad-spectrum antimicrobial efficacy of the premixed bone cements, including effectiveness against gram-positive, gram-negative, and drug-resistant bacteria. Notably, in vivo studies revealed exceptional antimicrobial and osteogenic properties of the carvacrol-loaded cements, confirming the promising potential of the premixed cements for the healing of infected bone defects. T2 - Composites Part B: Engineering T1 - Carvacrol-loaded premixed calcium phosphate bone cements with exceptional osteogenic and antibacterial properties to heal infected bone defects VL - 287 SP - 111812 DO - 10.1016/j.compositesb.2024.111812 ER -
@article{ author = "Cui, Chen and Liu, Dachuan and Xie, Xiaobin and Wang, Lijie and Lukić, Miodrag J. and Qiu, Xubin and Chen, Weicheng and Shi, Jiaxu and Hong, Youzhi and Li, Bin and Liu, Zhiwei and Chen, Song", year = "2024", abstract = "The healing of infected bone fractures represents a significant clinical challenge in orthopedic surgery. Calcium phosphate cements (CPCs) are attractive materials, highly applicable in bone healing due to their satisfactory biological properties and chemical similarity to bone minerals. However, manual mixing is often required before localized application of conventional CPCs, increasing the risk of infection. Moreover, their antibacterial properties are often insufficient for treating infected fractures. In this study, antimicrobial two-paste premixed CPCs loaded with carvacrol were developed. The influence of the carvacrol on the setting properties and mechanical strength of the cement was studied. In vitro studies demonstrated the biocompatibility, osteogenic potential, and broad-spectrum antimicrobial efficacy of the premixed bone cements, including effectiveness against gram-positive, gram-negative, and drug-resistant bacteria. Notably, in vivo studies revealed exceptional antimicrobial and osteogenic properties of the carvacrol-loaded cements, confirming the promising potential of the premixed cements for the healing of infected bone defects.", journal = "Composites Part B: Engineering", title = "Carvacrol-loaded premixed calcium phosphate bone cements with exceptional osteogenic and antibacterial properties to heal infected bone defects", volume = "287", pages = "111812", doi = "10.1016/j.compositesb.2024.111812" }
Cui, C., Liu, D., Xie, X., Wang, L., Lukić, M. J., Qiu, X., Chen, W., Shi, J., Hong, Y., Li, B., Liu, Z.,& Chen, S.. (2024). Carvacrol-loaded premixed calcium phosphate bone cements with exceptional osteogenic and antibacterial properties to heal infected bone defects. in Composites Part B: Engineering, 287, 111812. https://doi.org/10.1016/j.compositesb.2024.111812
Cui C, Liu D, Xie X, Wang L, Lukić MJ, Qiu X, Chen W, Shi J, Hong Y, Li B, Liu Z, Chen S. Carvacrol-loaded premixed calcium phosphate bone cements with exceptional osteogenic and antibacterial properties to heal infected bone defects. in Composites Part B: Engineering. 2024;287:111812. doi:10.1016/j.compositesb.2024.111812 .
Cui, Chen, Liu, Dachuan, Xie, Xiaobin, Wang, Lijie, Lukić, Miodrag J., Qiu, Xubin, Chen, Weicheng, Shi, Jiaxu, Hong, Youzhi, Li, Bin, Liu, Zhiwei, Chen, Song, "Carvacrol-loaded premixed calcium phosphate bone cements with exceptional osteogenic and antibacterial properties to heal infected bone defects" in Composites Part B: Engineering, 287 (2024):111812, https://doi.org/10.1016/j.compositesb.2024.111812 . .