Antidepressant Action on Mitochondrial Dysfunction in Psychiatric Disorders
Само за регистроване кориснике
2016
Приказ (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Mitochondria are cell organelles crucial to the production of cellular energy. Several lines of evidence have indicated that mitochondrial dysfunction could be related to the pathophysiology of CNS diseases including bipolar disorder, major depressive disorder, and schizophrenia. These changes include impaired energy metabolism in the brain, co-morbidity with mitochondrial diseases, the effects of psychotropics on mitochondrial function, increased mitochondrial DNA (mtDNA) deletion in the brain, and association with mtDNA polymorphisms. Additionally, psychotropic drug treatments can alter energy metabolism and may affect mitochondrial processes. This review focuses on recent findings regarding the effects of antidepressants on mitochondrial processes in psychiatric disorders. Drug Dev Res 77 : 400-406, 2016. (c) 2016 Wiley Periodicals, Inc.
Кључне речи:
mitochondria / psychiatric disorders / antidepressants / intracellular signaling / brain energy metabolismИзвор:
Drug Development Research, 2016, 77, 7, 400-406Финансирање / пројекти:
DOI: 10.1002/ddr.21332
ISSN: 0272-4391; 1098-2299
PubMed: 27539538
WoS: 000387856500009
Scopus: 2-s2.0-84994577874
Институција/група
VinčaTY - JOUR AU - Adžić, Miroslav AU - Brkić, Željka AU - Bulajić, Sonja AU - Mitić, Miloš AU - Radojčić, Marija PY - 2016 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1304 AB - Mitochondria are cell organelles crucial to the production of cellular energy. Several lines of evidence have indicated that mitochondrial dysfunction could be related to the pathophysiology of CNS diseases including bipolar disorder, major depressive disorder, and schizophrenia. These changes include impaired energy metabolism in the brain, co-morbidity with mitochondrial diseases, the effects of psychotropics on mitochondrial function, increased mitochondrial DNA (mtDNA) deletion in the brain, and association with mtDNA polymorphisms. Additionally, psychotropic drug treatments can alter energy metabolism and may affect mitochondrial processes. This review focuses on recent findings regarding the effects of antidepressants on mitochondrial processes in psychiatric disorders. Drug Dev Res 77 : 400-406, 2016. (c) 2016 Wiley Periodicals, Inc. T2 - Drug Development Research T1 - Antidepressant Action on Mitochondrial Dysfunction in Psychiatric Disorders VL - 77 IS - 7 SP - 400 EP - 406 DO - 10.1002/ddr.21332 ER -
@article{ author = "Adžić, Miroslav and Brkić, Željka and Bulajić, Sonja and Mitić, Miloš and Radojčić, Marija", year = "2016", abstract = "Mitochondria are cell organelles crucial to the production of cellular energy. Several lines of evidence have indicated that mitochondrial dysfunction could be related to the pathophysiology of CNS diseases including bipolar disorder, major depressive disorder, and schizophrenia. These changes include impaired energy metabolism in the brain, co-morbidity with mitochondrial diseases, the effects of psychotropics on mitochondrial function, increased mitochondrial DNA (mtDNA) deletion in the brain, and association with mtDNA polymorphisms. Additionally, psychotropic drug treatments can alter energy metabolism and may affect mitochondrial processes. This review focuses on recent findings regarding the effects of antidepressants on mitochondrial processes in psychiatric disorders. Drug Dev Res 77 : 400-406, 2016. (c) 2016 Wiley Periodicals, Inc.", journal = "Drug Development Research", title = "Antidepressant Action on Mitochondrial Dysfunction in Psychiatric Disorders", volume = "77", number = "7", pages = "400-406", doi = "10.1002/ddr.21332" }
Adžić, M., Brkić, Ž., Bulajić, S., Mitić, M.,& Radojčić, M.. (2016). Antidepressant Action on Mitochondrial Dysfunction in Psychiatric Disorders. in Drug Development Research, 77(7), 400-406. https://doi.org/10.1002/ddr.21332
Adžić M, Brkić Ž, Bulajić S, Mitić M, Radojčić M. Antidepressant Action on Mitochondrial Dysfunction in Psychiatric Disorders. in Drug Development Research. 2016;77(7):400-406. doi:10.1002/ddr.21332 .
Adžić, Miroslav, Brkić, Željka, Bulajić, Sonja, Mitić, Miloš, Radojčić, Marija, "Antidepressant Action on Mitochondrial Dysfunction in Psychiatric Disorders" in Drug Development Research, 77, no. 7 (2016):400-406, https://doi.org/10.1002/ddr.21332 . .