Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress
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2016
Authors
Pejić, SnežanaStojiljković, Vesna
Todorović, Ana
Gavrilović, Ljubica
Pavlović, Ivan
Popović, Nataša M.
Pajović, Snežana B.
Article (Published version)
,
© Institute of Systematics and Evolution of Animals, PAS, Kraków, 2016.
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The study deals with manganese superoxide dismutase, copper, zinc superoxide dismutase, and catalase activities in brain cortex of Wistar rats exposed to acute stress (immobilization or cold for 2 h), chronic stress (long-term isolation or long-term forced swimming for 21 days), or to combined chronic/acute stress. We observed that i) single episodes of acute stress by immobilization increased activity of both superoxide dismutases; ii) both types of chronic stresses significantly elevated activities of all examined enzymes; iii) chronic social isolation was a much stronger stressor than physical stress by swimming; iv) in animals pre-exposed to chronic isolation, additional stress by immobilization or cold significantly decreased previously elevated activities of all enzymes, while after chronic swimming, acute immobilization lowered only catalase activity. The obtained results indicate that stress conditions most probably altered the cell redox equilibrium, thus influencing the antio...xidant response in brain cortex. Further investigation of neuronal prooxidant/antioxidant cellular conditions is needed to improve the prevention and treatment of various stress induced diseases.
Keywords:
Antioxidant enzymes / reactive oxygen species / acute stress / chronic stress / brain cortexSource:
Folia Biologica (Krakow), 2016, 64, 3, 189-195Funding / projects:
- Cellular and molecular basis of malignant and cardiovascular diseases-clinical implications (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41027)
- Acute coronary syndrome: investigation of vulnerability (plaque, blood and myocardium), optimal treatment and determination of the factors for the prognosis (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41022)
DOI: 10.3409/fb64_3.189
ISSN: 0015-5497; 1734-9168
PubMed: 29847079
WoS: 000387737300006
Scopus: 2-s2.0-85006048069
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VinčaTY - JOUR AU - Pejić, Snežana AU - Stojiljković, Vesna AU - Todorović, Ana AU - Gavrilović, Ljubica AU - Pavlović, Ivan AU - Popović, Nataša M. AU - Pajović, Snežana B. PY - 2016 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1301 AB - The study deals with manganese superoxide dismutase, copper, zinc superoxide dismutase, and catalase activities in brain cortex of Wistar rats exposed to acute stress (immobilization or cold for 2 h), chronic stress (long-term isolation or long-term forced swimming for 21 days), or to combined chronic/acute stress. We observed that i) single episodes of acute stress by immobilization increased activity of both superoxide dismutases; ii) both types of chronic stresses significantly elevated activities of all examined enzymes; iii) chronic social isolation was a much stronger stressor than physical stress by swimming; iv) in animals pre-exposed to chronic isolation, additional stress by immobilization or cold significantly decreased previously elevated activities of all enzymes, while after chronic swimming, acute immobilization lowered only catalase activity. The obtained results indicate that stress conditions most probably altered the cell redox equilibrium, thus influencing the antioxidant response in brain cortex. Further investigation of neuronal prooxidant/antioxidant cellular conditions is needed to improve the prevention and treatment of various stress induced diseases. T2 - Folia Biologica (Krakow) T1 - Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress VL - 64 IS - 3 SP - 189 EP - 195 DO - 10.3409/fb64_3.189 ER -
@article{ author = "Pejić, Snežana and Stojiljković, Vesna and Todorović, Ana and Gavrilović, Ljubica and Pavlović, Ivan and Popović, Nataša M. and Pajović, Snežana B.", year = "2016", abstract = "The study deals with manganese superoxide dismutase, copper, zinc superoxide dismutase, and catalase activities in brain cortex of Wistar rats exposed to acute stress (immobilization or cold for 2 h), chronic stress (long-term isolation or long-term forced swimming for 21 days), or to combined chronic/acute stress. We observed that i) single episodes of acute stress by immobilization increased activity of both superoxide dismutases; ii) both types of chronic stresses significantly elevated activities of all examined enzymes; iii) chronic social isolation was a much stronger stressor than physical stress by swimming; iv) in animals pre-exposed to chronic isolation, additional stress by immobilization or cold significantly decreased previously elevated activities of all enzymes, while after chronic swimming, acute immobilization lowered only catalase activity. The obtained results indicate that stress conditions most probably altered the cell redox equilibrium, thus influencing the antioxidant response in brain cortex. Further investigation of neuronal prooxidant/antioxidant cellular conditions is needed to improve the prevention and treatment of various stress induced diseases.", journal = "Folia Biologica (Krakow)", title = "Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress", volume = "64", number = "3", pages = "189-195", doi = "10.3409/fb64_3.189" }
Pejić, S., Stojiljković, V., Todorović, A., Gavrilović, L., Pavlović, I., Popović, N. M.,& Pajović, S. B.. (2016). Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress. in Folia Biologica (Krakow), 64(3), 189-195. https://doi.org/10.3409/fb64_3.189
Pejić S, Stojiljković V, Todorović A, Gavrilović L, Pavlović I, Popović NM, Pajović SB. Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress. in Folia Biologica (Krakow). 2016;64(3):189-195. doi:10.3409/fb64_3.189 .
Pejić, Snežana, Stojiljković, Vesna, Todorović, Ana, Gavrilović, Ljubica, Pavlović, Ivan, Popović, Nataša M., Pajović, Snežana B., "Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress" in Folia Biologica (Krakow), 64, no. 3 (2016):189-195, https://doi.org/10.3409/fb64_3.189 . .