Correlations of CDKN1A and ADAM17 expression with a change of left ventricular remodeling echocardiographic parameters in PBMC of patients six months after the first myocardial infarction
2023
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Конференцијски прилог (Објављена верзија)
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Introduction: Myocardial infarction (MI) and consequential ischemia with cardiomyocyte loss are followed by left ventricular (LV) remodeling. LV remodeling is crucial process for cardiac function preservation, although when prolonged it can become maladaptive and lead to impaired systolic function and further cardiovascular complications. Echocardiographic parameters are used as a measure of LV structure and function. ADAM17 (a disintegrin and metalloprotease domain) and CDKN1A (cyclindependent kinase inhibitor 1A) have shown regulating role in DNA repair, inflammation, remodeling and fibrosis. The aim of this preliminary study was to investigate the potential effect of CDKN1 and ADAM17 mRNA in post MI heart remodeling. Methods: Sixty four patients with the first MI were prospectively followed-up 6 months after MI. Change (Δ) of echocardiographic parameters within 6 months was calculated as a difference between the value at 6-month follow-up and value at admission. Relative gene expres...sion was detected using the TaqMan® technology. Statistical analyses were done by Statistica 8 software. Results: We have observed correlation between CDKN1A mRNA expression and change of LV enddiastolic diameter (ΔLVEDD, R=0.3, p=0.01) and LV end-systolic diameter (ΔLVESD, R=0.3, p=0.02), but not with LV ejection fraction and stroke volume. ADAM17 expression was not in correlation with analyzed parameters of LV remodeling. However, CDKN1A and ADAM17 mRNA expression in PBMC six months after MI were positively correlated (R=0.6, p<0.001). Conclusion: Preliminary resultssuggest that CDKN1 has a role in post MI LV remodeling, correlating with changes in echocardiographic parameters of LV structure. The validation on a larger sample size is required.
Кључне речи:
myocardial infarction / LV remodeling / CDKN1A / ADAM17 / gene expressionИзвор:
CoMBoS2 – the Second Congress of Molecular Biologists of Serbia : Book of abstracts, 2023, 53-53Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)
Напомена:
- The Second Congress of Molecular Biologists of Serbia; October 6-8, Belgrade, 2023.
Колекције
Институција/група
VinčaTY - CONF AU - Kuveljić, Jovana AU - Životić, Ivan AU - Dekleva, Milica AU - Živković, Maja AU - Đurić, Tamara PY - 2023 UR - https://vinar.vin.bg.ac.rs/handle/123456789/12648 AB - Introduction: Myocardial infarction (MI) and consequential ischemia with cardiomyocyte loss are followed by left ventricular (LV) remodeling. LV remodeling is crucial process for cardiac function preservation, although when prolonged it can become maladaptive and lead to impaired systolic function and further cardiovascular complications. Echocardiographic parameters are used as a measure of LV structure and function. ADAM17 (a disintegrin and metalloprotease domain) and CDKN1A (cyclindependent kinase inhibitor 1A) have shown regulating role in DNA repair, inflammation, remodeling and fibrosis. The aim of this preliminary study was to investigate the potential effect of CDKN1 and ADAM17 mRNA in post MI heart remodeling. Methods: Sixty four patients with the first MI were prospectively followed-up 6 months after MI. Change (Δ) of echocardiographic parameters within 6 months was calculated as a difference between the value at 6-month follow-up and value at admission. Relative gene expression was detected using the TaqMan® technology. Statistical analyses were done by Statistica 8 software. Results: We have observed correlation between CDKN1A mRNA expression and change of LV enddiastolic diameter (ΔLVEDD, R=0.3, p=0.01) and LV end-systolic diameter (ΔLVESD, R=0.3, p=0.02), but not with LV ejection fraction and stroke volume. ADAM17 expression was not in correlation with analyzed parameters of LV remodeling. However, CDKN1A and ADAM17 mRNA expression in PBMC six months after MI were positively correlated (R=0.6, p<0.001). Conclusion: Preliminary resultssuggest that CDKN1 has a role in post MI LV remodeling, correlating with changes in echocardiographic parameters of LV structure. The validation on a larger sample size is required. C3 - CoMBoS2 – the Second Congress of Molecular Biologists of Serbia : Book of abstracts T1 - Correlations of CDKN1A and ADAM17 expression with a change of left ventricular remodeling echocardiographic parameters in PBMC of patients six months after the first myocardial infarction SP - 53 EP - 53 UR - https://hdl.handle.net/21.15107/rcub_vinar_12648 ER -
@conference{ author = "Kuveljić, Jovana and Životić, Ivan and Dekleva, Milica and Živković, Maja and Đurić, Tamara", year = "2023", abstract = "Introduction: Myocardial infarction (MI) and consequential ischemia with cardiomyocyte loss are followed by left ventricular (LV) remodeling. LV remodeling is crucial process for cardiac function preservation, although when prolonged it can become maladaptive and lead to impaired systolic function and further cardiovascular complications. Echocardiographic parameters are used as a measure of LV structure and function. ADAM17 (a disintegrin and metalloprotease domain) and CDKN1A (cyclindependent kinase inhibitor 1A) have shown regulating role in DNA repair, inflammation, remodeling and fibrosis. The aim of this preliminary study was to investigate the potential effect of CDKN1 and ADAM17 mRNA in post MI heart remodeling. Methods: Sixty four patients with the first MI were prospectively followed-up 6 months after MI. Change (Δ) of echocardiographic parameters within 6 months was calculated as a difference between the value at 6-month follow-up and value at admission. Relative gene expression was detected using the TaqMan® technology. Statistical analyses were done by Statistica 8 software. Results: We have observed correlation between CDKN1A mRNA expression and change of LV enddiastolic diameter (ΔLVEDD, R=0.3, p=0.01) and LV end-systolic diameter (ΔLVESD, R=0.3, p=0.02), but not with LV ejection fraction and stroke volume. ADAM17 expression was not in correlation with analyzed parameters of LV remodeling. However, CDKN1A and ADAM17 mRNA expression in PBMC six months after MI were positively correlated (R=0.6, p<0.001). Conclusion: Preliminary resultssuggest that CDKN1 has a role in post MI LV remodeling, correlating with changes in echocardiographic parameters of LV structure. The validation on a larger sample size is required.", journal = "CoMBoS2 – the Second Congress of Molecular Biologists of Serbia : Book of abstracts", title = "Correlations of CDKN1A and ADAM17 expression with a change of left ventricular remodeling echocardiographic parameters in PBMC of patients six months after the first myocardial infarction", pages = "53-53", url = "https://hdl.handle.net/21.15107/rcub_vinar_12648" }
Kuveljić, J., Životić, I., Dekleva, M., Živković, M.,& Đurić, T.. (2023). Correlations of CDKN1A and ADAM17 expression with a change of left ventricular remodeling echocardiographic parameters in PBMC of patients six months after the first myocardial infarction. in CoMBoS2 – the Second Congress of Molecular Biologists of Serbia : Book of abstracts, 53-53. https://hdl.handle.net/21.15107/rcub_vinar_12648
Kuveljić J, Životić I, Dekleva M, Živković M, Đurić T. Correlations of CDKN1A and ADAM17 expression with a change of left ventricular remodeling echocardiographic parameters in PBMC of patients six months after the first myocardial infarction. in CoMBoS2 – the Second Congress of Molecular Biologists of Serbia : Book of abstracts. 2023;:53-53. https://hdl.handle.net/21.15107/rcub_vinar_12648 .
Kuveljić, Jovana, Životić, Ivan, Dekleva, Milica, Živković, Maja, Đurić, Tamara, "Correlations of CDKN1A and ADAM17 expression with a change of left ventricular remodeling echocardiographic parameters in PBMC of patients six months after the first myocardial infarction" in CoMBoS2 – the Second Congress of Molecular Biologists of Serbia : Book of abstracts (2023):53-53, https://hdl.handle.net/21.15107/rcub_vinar_12648 .