Development of photo-sensitive nanocomposite system for controlled metallo-drug delivery in skin cancer therapy
Authors
Nešić, Maja D.Stepić, Milutin
Korićanac, Lela
Radoičić, Marija
Šaponjić, Zoran
Popović, Iva
Petković, Marijana
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There has been a growing demand for development and improvement of cancer treatment in order to overcome disadvantages and limitations of traditional chemotherapy such as resistance, toxicity, and activity against a small number of tumor types. Photodynamic therapy is a rapidly developing cancer treatment that utilizes the combination of photoactive drug and/or carrier and light as an external stimulus to destroy tumors, achieve a maximum concentration of the drug on tumor site, reduce side effects of drug onto the healthy tissue, enable dosage control, and more effective treatment which could improve outcome of therapy [1]. We investigated possibility to use ТiО2 nanoparticles as a carrier for potential antitumor drug [Ru(II)(dcbpy)2Cl2], cis-dichlorobis (2, 2'-bipyridyl-4, 4'-dicarboxylicacid) ruthenium(II). Nanocomposite system has been formed by binding of ruthenium complex to the ТiО2 nanoparticles. Components of the system are selected according to their preferences, such as bioc...ompatibility, photo activity, and easy surface modification for ТiО2, and less toxicity, significant activity against cancer metastases, and activity on tumors that were resistant to a variety of standard chemotherapeutic agents for Ru-complexes. Both components of the system are also photoactive, therefore potential for system manipulation and use in photodinamic therapy has been investigated by irradiation with UV and visible light. Additionally, the feasibility of using this system as a light-triggered drug delivery system was shown on amelanotic melanoma cancer line. The experimental results revealed a potential of nanocomposite system for long-term constant release of complex which is suitable for clinical practice. The further investigation of nanocomposite system indicated that it exhibited UV and red light susceptible drug release behavior [2]. More precisely, the system demonstrated slower complex release upon visible and increased release rate upon UV light illumination which was also in good correlation with the light–dependent cytotoxicity of the system demonstrated on amelanotic melanoma cancer line. The melanoma cancer cell death is enhanced by UV and reduced by red light in the presence of investigated nanocomposite system [3]. All obtained results suggested that nanocomposite system may have a potential use as a light sensitive drug delivery system in photodynamic therapy which could significantly contribute to development of more efficient and less invasive therapy of melanoma which is highly aggressive and deadliest form of skin cancer.
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PHOTONICA2019 : 7th International School and Conference on Photonics & Machine Learning with Photonics Symposium : Book of abstracts, 2019, 39-39Publisher:
- Belgrade : Vinča Institute of Nuclear Sciences, University of Belgrade
Note:
- VII International School and Conference on Photonics : PHOTONICA2019 : Abstracts of Tutorial, Keynote, Invited Lectures, Progress Reports and Contributed Papers; August 26-30; Belgrade
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VinčaTY - CONF AU - Nešić, Maja D. AU - Stepić, Milutin AU - Korićanac, Lela AU - Radoičić, Marija AU - Šaponjić, Zoran AU - Popović, Iva AU - Petković, Marijana PY - 2019 UR - https://vinar.vin.bg.ac.rs/handle/123456789/11891 AB - There has been a growing demand for development and improvement of cancer treatment in order to overcome disadvantages and limitations of traditional chemotherapy such as resistance, toxicity, and activity against a small number of tumor types. Photodynamic therapy is a rapidly developing cancer treatment that utilizes the combination of photoactive drug and/or carrier and light as an external stimulus to destroy tumors, achieve a maximum concentration of the drug on tumor site, reduce side effects of drug onto the healthy tissue, enable dosage control, and more effective treatment which could improve outcome of therapy [1]. We investigated possibility to use ТiО2 nanoparticles as a carrier for potential antitumor drug [Ru(II)(dcbpy)2Cl2], cis-dichlorobis (2, 2'-bipyridyl-4, 4'-dicarboxylicacid) ruthenium(II). Nanocomposite system has been formed by binding of ruthenium complex to the ТiО2 nanoparticles. Components of the system are selected according to their preferences, such as biocompatibility, photo activity, and easy surface modification for ТiО2, and less toxicity, significant activity against cancer metastases, and activity on tumors that were resistant to a variety of standard chemotherapeutic agents for Ru-complexes. Both components of the system are also photoactive, therefore potential for system manipulation and use in photodinamic therapy has been investigated by irradiation with UV and visible light. Additionally, the feasibility of using this system as a light-triggered drug delivery system was shown on amelanotic melanoma cancer line. The experimental results revealed a potential of nanocomposite system for long-term constant release of complex which is suitable for clinical practice. The further investigation of nanocomposite system indicated that it exhibited UV and red light susceptible drug release behavior [2]. More precisely, the system demonstrated slower complex release upon visible and increased release rate upon UV light illumination which was also in good correlation with the light–dependent cytotoxicity of the system demonstrated on amelanotic melanoma cancer line. The melanoma cancer cell death is enhanced by UV and reduced by red light in the presence of investigated nanocomposite system [3]. All obtained results suggested that nanocomposite system may have a potential use as a light sensitive drug delivery system in photodynamic therapy which could significantly contribute to development of more efficient and less invasive therapy of melanoma which is highly aggressive and deadliest form of skin cancer. PB - Belgrade : Vinča Institute of Nuclear Sciences, University of Belgrade C3 - PHOTONICA2019 : 7th International School and Conference on Photonics & Machine Learning with Photonics Symposium : Book of abstracts T1 - Development of photo-sensitive nanocomposite system for controlled metallo-drug delivery in skin cancer therapy SP - 39 EP - 39 UR - https://hdl.handle.net/21.15107/rcub_vinar_11891 ER -
@conference{ author = "Nešić, Maja D. and Stepić, Milutin and Korićanac, Lela and Radoičić, Marija and Šaponjić, Zoran and Popović, Iva and Petković, Marijana", year = "2019", abstract = "There has been a growing demand for development and improvement of cancer treatment in order to overcome disadvantages and limitations of traditional chemotherapy such as resistance, toxicity, and activity against a small number of tumor types. Photodynamic therapy is a rapidly developing cancer treatment that utilizes the combination of photoactive drug and/or carrier and light as an external stimulus to destroy tumors, achieve a maximum concentration of the drug on tumor site, reduce side effects of drug onto the healthy tissue, enable dosage control, and more effective treatment which could improve outcome of therapy [1]. We investigated possibility to use ТiО2 nanoparticles as a carrier for potential antitumor drug [Ru(II)(dcbpy)2Cl2], cis-dichlorobis (2, 2'-bipyridyl-4, 4'-dicarboxylicacid) ruthenium(II). Nanocomposite system has been formed by binding of ruthenium complex to the ТiО2 nanoparticles. Components of the system are selected according to their preferences, such as biocompatibility, photo activity, and easy surface modification for ТiО2, and less toxicity, significant activity against cancer metastases, and activity on tumors that were resistant to a variety of standard chemotherapeutic agents for Ru-complexes. Both components of the system are also photoactive, therefore potential for system manipulation and use in photodinamic therapy has been investigated by irradiation with UV and visible light. Additionally, the feasibility of using this system as a light-triggered drug delivery system was shown on amelanotic melanoma cancer line. The experimental results revealed a potential of nanocomposite system for long-term constant release of complex which is suitable for clinical practice. The further investigation of nanocomposite system indicated that it exhibited UV and red light susceptible drug release behavior [2]. More precisely, the system demonstrated slower complex release upon visible and increased release rate upon UV light illumination which was also in good correlation with the light–dependent cytotoxicity of the system demonstrated on amelanotic melanoma cancer line. The melanoma cancer cell death is enhanced by UV and reduced by red light in the presence of investigated nanocomposite system [3]. All obtained results suggested that nanocomposite system may have a potential use as a light sensitive drug delivery system in photodynamic therapy which could significantly contribute to development of more efficient and less invasive therapy of melanoma which is highly aggressive and deadliest form of skin cancer.", publisher = "Belgrade : Vinča Institute of Nuclear Sciences, University of Belgrade", journal = "PHOTONICA2019 : 7th International School and Conference on Photonics & Machine Learning with Photonics Symposium : Book of abstracts", title = "Development of photo-sensitive nanocomposite system for controlled metallo-drug delivery in skin cancer therapy", pages = "39-39", url = "https://hdl.handle.net/21.15107/rcub_vinar_11891" }
Nešić, M. D., Stepić, M., Korićanac, L., Radoičić, M., Šaponjić, Z., Popović, I.,& Petković, M.. (2019). Development of photo-sensitive nanocomposite system for controlled metallo-drug delivery in skin cancer therapy. in PHOTONICA2019 : 7th International School and Conference on Photonics & Machine Learning with Photonics Symposium : Book of abstracts Belgrade : Vinča Institute of Nuclear Sciences, University of Belgrade., 39-39. https://hdl.handle.net/21.15107/rcub_vinar_11891
Nešić MD, Stepić M, Korićanac L, Radoičić M, Šaponjić Z, Popović I, Petković M. Development of photo-sensitive nanocomposite system for controlled metallo-drug delivery in skin cancer therapy. in PHOTONICA2019 : 7th International School and Conference on Photonics & Machine Learning with Photonics Symposium : Book of abstracts. 2019;:39-39. https://hdl.handle.net/21.15107/rcub_vinar_11891 .
Nešić, Maja D., Stepić, Milutin, Korićanac, Lela, Radoičić, Marija, Šaponjić, Zoran, Popović, Iva, Petković, Marijana, "Development of photo-sensitive nanocomposite system for controlled metallo-drug delivery in skin cancer therapy" in PHOTONICA2019 : 7th International School and Conference on Photonics & Machine Learning with Photonics Symposium : Book of abstracts (2019):39-39, https://hdl.handle.net/21.15107/rcub_vinar_11891 .