Swelling properties and drug release of new biocompatible POEGOPGMA hydrogels with VPTT near to the human body temperature
Abstract
Oligo (ethylene glycol) oligo (propylene glycol) methacrylates (OEGOPGMA) with diferent numbers of ethylene glycol (EG) and propylene glycol (PG) units in backbone were used for the preparation of new thermoresponsive POEGOPGMA hydrogels; EG6PG3MA and EG3PG6MA monomers were used; and three diferent POEGOPGMA hydrogels (PEG6PG3MA, PEG3PG6MA and P(EG6PG3/EG3PG6) MA copolymer with equal mol% of previous two) were fabricated from mono‑ mer–solvent (OEGOPGMA–water/ethanol) mixture by gamma radiation. Charac‑ terisation of the hydrogels was conducted by swelling, UV–Vis, scanning electron microscope, diferential scanning calorimetry and in vitro biocompatibility (cyto‑ compatibility and haemolytic activity) investigations. The modelling of drug release and difusion characteristics was tested using cephalexin drug. For the frst time, it was shown how to efectively tune the volume phase transition temperature (VPTT) values of the hydrogels by changing the ratio of more hydrophilic (EG) and mo...re hydrophobic (PG) units in (EGPG) “block” pendant chains. The obtained hydrogels revealed the great potential for diferent biomedical applications not only due to the possibility to tune VPTT in the desired way but also due to the good biocompatibil‑ ity and controlled drug delivery within the target temperature range.
Keywords:
Hydrogel / Thermoresponsive / EGPG pendant chain / VPTTSource:
Polymer Bulletin, 2021, 78, 2405-2425Funding / projects:
- Chemical and structural designing of nanomaterials for application in medicine and tissue engineering (RS-MESTD-Basic Research (BR or ON)-172026)
- Functional, Functionalized and Advanced Nanomaterials (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45005)
DOI: 10.1007/s00289-020-03217-0
ISSN: 0170-0839
WoS: 000530585100001
Scopus: 2-s2.0-85085152021
Institution/Community
VinčaTY - JOUR AU - Suljovrujić, Edin H. AU - Rogić Miladinović, Zorana AU - Krstić, Maja PY - 2021 UR - https://vinar.vin.bg.ac.rs/handle/123456789/11469 AB - Oligo (ethylene glycol) oligo (propylene glycol) methacrylates (OEGOPGMA) with diferent numbers of ethylene glycol (EG) and propylene glycol (PG) units in backbone were used for the preparation of new thermoresponsive POEGOPGMA hydrogels; EG6PG3MA and EG3PG6MA monomers were used; and three diferent POEGOPGMA hydrogels (PEG6PG3MA, PEG3PG6MA and P(EG6PG3/EG3PG6) MA copolymer with equal mol% of previous two) were fabricated from mono‑ mer–solvent (OEGOPGMA–water/ethanol) mixture by gamma radiation. Charac‑ terisation of the hydrogels was conducted by swelling, UV–Vis, scanning electron microscope, diferential scanning calorimetry and in vitro biocompatibility (cyto‑ compatibility and haemolytic activity) investigations. The modelling of drug release and difusion characteristics was tested using cephalexin drug. For the frst time, it was shown how to efectively tune the volume phase transition temperature (VPTT) values of the hydrogels by changing the ratio of more hydrophilic (EG) and more hydrophobic (PG) units in (EGPG) “block” pendant chains. The obtained hydrogels revealed the great potential for diferent biomedical applications not only due to the possibility to tune VPTT in the desired way but also due to the good biocompatibil‑ ity and controlled drug delivery within the target temperature range. T2 - Polymer Bulletin T1 - Swelling properties and drug release of new biocompatible POEGOPGMA hydrogels with VPTT near to the human body temperature VL - 78 SP - 2405 EP - 2425 DO - 10.1007/s00289-020-03217-0 ER -
@article{ author = "Suljovrujić, Edin H. and Rogić Miladinović, Zorana and Krstić, Maja", year = "2021", abstract = "Oligo (ethylene glycol) oligo (propylene glycol) methacrylates (OEGOPGMA) with diferent numbers of ethylene glycol (EG) and propylene glycol (PG) units in backbone were used for the preparation of new thermoresponsive POEGOPGMA hydrogels; EG6PG3MA and EG3PG6MA monomers were used; and three diferent POEGOPGMA hydrogels (PEG6PG3MA, PEG3PG6MA and P(EG6PG3/EG3PG6) MA copolymer with equal mol% of previous two) were fabricated from mono‑ mer–solvent (OEGOPGMA–water/ethanol) mixture by gamma radiation. Charac‑ terisation of the hydrogels was conducted by swelling, UV–Vis, scanning electron microscope, diferential scanning calorimetry and in vitro biocompatibility (cyto‑ compatibility and haemolytic activity) investigations. The modelling of drug release and difusion characteristics was tested using cephalexin drug. For the frst time, it was shown how to efectively tune the volume phase transition temperature (VPTT) values of the hydrogels by changing the ratio of more hydrophilic (EG) and more hydrophobic (PG) units in (EGPG) “block” pendant chains. The obtained hydrogels revealed the great potential for diferent biomedical applications not only due to the possibility to tune VPTT in the desired way but also due to the good biocompatibil‑ ity and controlled drug delivery within the target temperature range.", journal = "Polymer Bulletin", title = "Swelling properties and drug release of new biocompatible POEGOPGMA hydrogels with VPTT near to the human body temperature", volume = "78", pages = "2405-2425", doi = "10.1007/s00289-020-03217-0" }
Suljovrujić, E. H., Rogić Miladinović, Z.,& Krstić, M.. (2021). Swelling properties and drug release of new biocompatible POEGOPGMA hydrogels with VPTT near to the human body temperature. in Polymer Bulletin, 78, 2405-2425. https://doi.org/10.1007/s00289-020-03217-0
Suljovrujić EH, Rogić Miladinović Z, Krstić M. Swelling properties and drug release of new biocompatible POEGOPGMA hydrogels with VPTT near to the human body temperature. in Polymer Bulletin. 2021;78:2405-2425. doi:10.1007/s00289-020-03217-0 .
Suljovrujić, Edin H., Rogić Miladinović, Zorana, Krstić, Maja, "Swelling properties and drug release of new biocompatible POEGOPGMA hydrogels with VPTT near to the human body temperature" in Polymer Bulletin, 78 (2021):2405-2425, https://doi.org/10.1007/s00289-020-03217-0 . .