Calcium messages in flagella are faster than messenger particles
Само за регистроване кориснике
2023
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Calcium is one of the most versatile messengers for intracellular signaling. In the case of cilia and flagella calcium has the central role in transfer of communications between extracellular stimuli and intracellular formation of frequency modulated signal and their deciphering by target proteins. In this paper, the diffusion of fluorescently or otherwise tagged and un-tagged Ca2+ particles is analyzed by solving the system of pertaining reaction–diffusion equations. We used Fourier transform tools to get asymptotic eigenfunctions for tagged (un-tagged) free and buffered Ca2+ ions. We made some numerical estimations for diffusion coefficients corroborating the fact that messages diffuse faster than Ca2+ messengers. From the best of our knowledge, this is the first time that Ca2+ signaling in living cells is biophysically elaborated within the framework of model presented here. We suggest the experimental assay on the basis of radioactive Ca2+ as tagged probe.
Кључне речи:
Ca ions / Calcium signaling / Microtubule / Reaction-diffusion equationИзвор:
Biosystems, 2023, 232, 105003-Финансирање / пројекти:
- Serbian Academy of Sciences and Arts [personal grant No. Φ134]
- Department of Fundamental Sciences at the Faculty of Technical Sciences at the University of Novi Sad [project ‘‘Application of Fundamental Disciplines in Technical and Information Sciences’’]
DOI: 10.1016/j.biosystems.2023.105003
ISSN: 0303-2647
PubMed: 37625514
Scopus: 2-s2.0-85168853511
Институција/група
VinčaTY - JOUR AU - Satarić, Miljko V. AU - Nemeš, Tomas AU - Zdravković, Slobodan PY - 2023 UR - https://vinar.vin.bg.ac.rs/handle/123456789/11445 AB - Calcium is one of the most versatile messengers for intracellular signaling. In the case of cilia and flagella calcium has the central role in transfer of communications between extracellular stimuli and intracellular formation of frequency modulated signal and their deciphering by target proteins. In this paper, the diffusion of fluorescently or otherwise tagged and un-tagged Ca2+ particles is analyzed by solving the system of pertaining reaction–diffusion equations. We used Fourier transform tools to get asymptotic eigenfunctions for tagged (un-tagged) free and buffered Ca2+ ions. We made some numerical estimations for diffusion coefficients corroborating the fact that messages diffuse faster than Ca2+ messengers. From the best of our knowledge, this is the first time that Ca2+ signaling in living cells is biophysically elaborated within the framework of model presented here. We suggest the experimental assay on the basis of radioactive Ca2+ as tagged probe. T2 - Biosystems T1 - Calcium messages in flagella are faster than messenger particles VL - 232 SP - 105003 DO - 10.1016/j.biosystems.2023.105003 ER -
@article{ author = "Satarić, Miljko V. and Nemeš, Tomas and Zdravković, Slobodan", year = "2023", abstract = "Calcium is one of the most versatile messengers for intracellular signaling. In the case of cilia and flagella calcium has the central role in transfer of communications between extracellular stimuli and intracellular formation of frequency modulated signal and their deciphering by target proteins. In this paper, the diffusion of fluorescently or otherwise tagged and un-tagged Ca2+ particles is analyzed by solving the system of pertaining reaction–diffusion equations. We used Fourier transform tools to get asymptotic eigenfunctions for tagged (un-tagged) free and buffered Ca2+ ions. We made some numerical estimations for diffusion coefficients corroborating the fact that messages diffuse faster than Ca2+ messengers. From the best of our knowledge, this is the first time that Ca2+ signaling in living cells is biophysically elaborated within the framework of model presented here. We suggest the experimental assay on the basis of radioactive Ca2+ as tagged probe.", journal = "Biosystems", title = "Calcium messages in flagella are faster than messenger particles", volume = "232", pages = "105003", doi = "10.1016/j.biosystems.2023.105003" }
Satarić, M. V., Nemeš, T.,& Zdravković, S.. (2023). Calcium messages in flagella are faster than messenger particles. in Biosystems, 232, 105003. https://doi.org/10.1016/j.biosystems.2023.105003
Satarić MV, Nemeš T, Zdravković S. Calcium messages in flagella are faster than messenger particles. in Biosystems. 2023;232:105003. doi:10.1016/j.biosystems.2023.105003 .
Satarić, Miljko V., Nemeš, Tomas, Zdravković, Slobodan, "Calcium messages in flagella are faster than messenger particles" in Biosystems, 232 (2023):105003, https://doi.org/10.1016/j.biosystems.2023.105003 . .