Dehydrozingerone based 1-acetyl-5-aryl-4,5-dihydro-1H-pyrazoles: Synthesis, characterization and anticancer activity
Само за регистроване кориснике
2016
Аутори
Ratković, Zoran R.Muškinja, Jovana
Burmudžija, Adrijana
Ranković, Branislav
Kosanić, Marijana
Bogdanović, Goran A.
Marković-Simović, Bojana
Nikolić, Aleksandar
Arsenijević, Nebojša N.
Đorđević, Snežana
Vukićević, Rastko D.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
A small series of 1-acetyl-5-aryl-4,5-dihydro-1H-pyrazoles (aryl = 4-hydroxy-3-methoxyphenyl and 4-alkoxy-3-methoxyphenyl) was prepared, starting from 4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-one, dehydrozingerone, and its alkyl derivatives. Their in vitro cytotoxic activity against some cancer cell lines was tested, showing significant anticancer activity. All the new compounds were well characterized by IR, H-1, C-13 NMR and ESI-MS spectroscopy and physical data, whereas structures of two of them were determined by single crystal X-ray analysis. (C) 2016 Elsevier B.V. All rights reserved.
Кључне речи:
Dehydrozingerone / Anticancer / Cytotoxicity / Crystal structureИзвор:
Journal of Molecular Structure, 2016, 1109, 82-88Финансирање / пројекти:
- Нове електрохемијске и хемијске методе у синтези органских једињења од интереса за медицину и хемију материјала (RS-MESTD-Basic Research (BR or ON)-172034)
- Дизајнирање, синтеза, карактеризација и процена практичне примене координационих и органометалних једињења (RS-MESTD-Basic Research (BR or ON)-172014)
- Развој инфраструктуре за приоритетна поља науке (RS-MESTD-Basic Research (BR or ON)-175103)
DOI: 10.1016/j.molstruc.2015.12.079
ISSN: 0022-2860; 1872-8014
WoS: 000378100700010
Scopus: 2-s2.0-84953455358
Колекције
Институција/група
VinčaTY - JOUR AU - Ratković, Zoran R. AU - Muškinja, Jovana AU - Burmudžija, Adrijana AU - Ranković, Branislav AU - Kosanić, Marijana AU - Bogdanović, Goran A. AU - Marković-Simović, Bojana AU - Nikolić, Aleksandar AU - Arsenijević, Nebojša N. AU - Đorđević, Snežana AU - Vukićević, Rastko D. PY - 2016 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1127 AB - A small series of 1-acetyl-5-aryl-4,5-dihydro-1H-pyrazoles (aryl = 4-hydroxy-3-methoxyphenyl and 4-alkoxy-3-methoxyphenyl) was prepared, starting from 4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-one, dehydrozingerone, and its alkyl derivatives. Their in vitro cytotoxic activity against some cancer cell lines was tested, showing significant anticancer activity. All the new compounds were well characterized by IR, H-1, C-13 NMR and ESI-MS spectroscopy and physical data, whereas structures of two of them were determined by single crystal X-ray analysis. (C) 2016 Elsevier B.V. All rights reserved. T2 - Journal of Molecular Structure T1 - Dehydrozingerone based 1-acetyl-5-aryl-4,5-dihydro-1H-pyrazoles: Synthesis, characterization and anticancer activity VL - 1109 SP - 82 EP - 88 DO - 10.1016/j.molstruc.2015.12.079 ER -
@article{ author = "Ratković, Zoran R. and Muškinja, Jovana and Burmudžija, Adrijana and Ranković, Branislav and Kosanić, Marijana and Bogdanović, Goran A. and Marković-Simović, Bojana and Nikolić, Aleksandar and Arsenijević, Nebojša N. and Đorđević, Snežana and Vukićević, Rastko D.", year = "2016", abstract = "A small series of 1-acetyl-5-aryl-4,5-dihydro-1H-pyrazoles (aryl = 4-hydroxy-3-methoxyphenyl and 4-alkoxy-3-methoxyphenyl) was prepared, starting from 4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-one, dehydrozingerone, and its alkyl derivatives. Their in vitro cytotoxic activity against some cancer cell lines was tested, showing significant anticancer activity. All the new compounds were well characterized by IR, H-1, C-13 NMR and ESI-MS spectroscopy and physical data, whereas structures of two of them were determined by single crystal X-ray analysis. (C) 2016 Elsevier B.V. All rights reserved.", journal = "Journal of Molecular Structure", title = "Dehydrozingerone based 1-acetyl-5-aryl-4,5-dihydro-1H-pyrazoles: Synthesis, characterization and anticancer activity", volume = "1109", pages = "82-88", doi = "10.1016/j.molstruc.2015.12.079" }
Ratković, Z. R., Muškinja, J., Burmudžija, A., Ranković, B., Kosanić, M., Bogdanović, G. A., Marković-Simović, B., Nikolić, A., Arsenijević, N. N., Đorđević, S.,& Vukićević, R. D.. (2016). Dehydrozingerone based 1-acetyl-5-aryl-4,5-dihydro-1H-pyrazoles: Synthesis, characterization and anticancer activity. in Journal of Molecular Structure, 1109, 82-88. https://doi.org/10.1016/j.molstruc.2015.12.079
Ratković ZR, Muškinja J, Burmudžija A, Ranković B, Kosanić M, Bogdanović GA, Marković-Simović B, Nikolić A, Arsenijević NN, Đorđević S, Vukićević RD. Dehydrozingerone based 1-acetyl-5-aryl-4,5-dihydro-1H-pyrazoles: Synthesis, characterization and anticancer activity. in Journal of Molecular Structure. 2016;1109:82-88. doi:10.1016/j.molstruc.2015.12.079 .
Ratković, Zoran R., Muškinja, Jovana, Burmudžija, Adrijana, Ranković, Branislav, Kosanić, Marijana, Bogdanović, Goran A., Marković-Simović, Bojana, Nikolić, Aleksandar, Arsenijević, Nebojša N., Đorđević, Snežana, Vukićević, Rastko D., "Dehydrozingerone based 1-acetyl-5-aryl-4,5-dihydro-1H-pyrazoles: Synthesis, characterization and anticancer activity" in Journal of Molecular Structure, 1109 (2016):82-88, https://doi.org/10.1016/j.molstruc.2015.12.079 . .