Cytotoxicity of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-ethyl derivative of thiosalicylic acid
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2016
Authors
Nikolić, Miloš V.Mijajlović, Marina Ž.
Jevtić, Verica V.
Ratković, Zoran R.
Novaković, Slađana B.
Bogdanović, Goran A.
Milovanović, Jelena
Arsenijević, Aleksandar
Stojanović, Bojana
Trifunović, Srećko R.
Radić, Gordana P.
Article (Published version)
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Show full item recordAbstract
The spectroscopically predicted structure of the obtained copper(II)-complex with S-ethyl derivative of thiosalicylic acid was confirmed by X-ray structural study and compared to previously reported crystal structure of the Cu complex with S-methyl derivative. Single crystals suitable for X-ray measurements were obtained by slow crystallization from a water solution. Cytotoxic effects of S-alkyl (R = benzyl (L1), methyl (12), ethyl (L3), propyl (IA) and butyl (L5)) derivatives of thiosalicylic acid and the corresponding binuclear copper(II)-complexes on murine colon carcinoma cell lines, 026 and CT26.CL25 and human colon carcinoma cell line HCT-116 were reported here. The analysis of cancer cell viability showed that all the tested complexes had low cytotoxic effect on murine colon carcinoma cell lines, but several times higher cytotoxicity on normal human colon carcinoma cells. (C) 2016 Elsevier B.V. All rights reserved.
Keywords:
Binuclear copper(II)-complexes / Crystal structure / CytotoxicitySource:
Journal of Molecular Structure, 2016, 1116, 264-271Publisher:
- Elsevier
Funding / projects:
- Synthesis, modeling, physicochemical and biological properties of organic compounds and related metal complexes (RS-MESTD-Basic Research (BR or ON)-172016)
- Novel Electrochemical and Chemical Methods in Synthesis of Organic Compounds of Interest for Medicine and Material Chemistry (RS-MESTD-Basic Research (BR or ON)-172034)
- Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology (RS-MESTD-Basic Research (BR or ON)-172035)
- Faculty of Medical Sciences [MP 2014/01]
DOI: 10.1016/j.molstruc.2016.03.058
ISSN: 0022-2860; 1872-8014
WoS: 000375740200031
Scopus: 2-s2.0-84961661678
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VinčaTY - JOUR AU - Nikolić, Miloš V. AU - Mijajlović, Marina Ž. AU - Jevtić, Verica V. AU - Ratković, Zoran R. AU - Novaković, Slađana B. AU - Bogdanović, Goran A. AU - Milovanović, Jelena AU - Arsenijević, Aleksandar AU - Stojanović, Bojana AU - Trifunović, Srećko R. AU - Radić, Gordana P. PY - 2016 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1068 AB - The spectroscopically predicted structure of the obtained copper(II)-complex with S-ethyl derivative of thiosalicylic acid was confirmed by X-ray structural study and compared to previously reported crystal structure of the Cu complex with S-methyl derivative. Single crystals suitable for X-ray measurements were obtained by slow crystallization from a water solution. Cytotoxic effects of S-alkyl (R = benzyl (L1), methyl (12), ethyl (L3), propyl (IA) and butyl (L5)) derivatives of thiosalicylic acid and the corresponding binuclear copper(II)-complexes on murine colon carcinoma cell lines, 026 and CT26.CL25 and human colon carcinoma cell line HCT-116 were reported here. The analysis of cancer cell viability showed that all the tested complexes had low cytotoxic effect on murine colon carcinoma cell lines, but several times higher cytotoxicity on normal human colon carcinoma cells. (C) 2016 Elsevier B.V. All rights reserved. PB - Elsevier T2 - Journal of Molecular Structure T1 - Cytotoxicity of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-ethyl derivative of thiosalicylic acid VL - 1116 SP - 264 EP - 271 DO - 10.1016/j.molstruc.2016.03.058 ER -
@article{ author = "Nikolić, Miloš V. and Mijajlović, Marina Ž. and Jevtić, Verica V. and Ratković, Zoran R. and Novaković, Slađana B. and Bogdanović, Goran A. and Milovanović, Jelena and Arsenijević, Aleksandar and Stojanović, Bojana and Trifunović, Srećko R. and Radić, Gordana P.", year = "2016", abstract = "The spectroscopically predicted structure of the obtained copper(II)-complex with S-ethyl derivative of thiosalicylic acid was confirmed by X-ray structural study and compared to previously reported crystal structure of the Cu complex with S-methyl derivative. Single crystals suitable for X-ray measurements were obtained by slow crystallization from a water solution. Cytotoxic effects of S-alkyl (R = benzyl (L1), methyl (12), ethyl (L3), propyl (IA) and butyl (L5)) derivatives of thiosalicylic acid and the corresponding binuclear copper(II)-complexes on murine colon carcinoma cell lines, 026 and CT26.CL25 and human colon carcinoma cell line HCT-116 were reported here. The analysis of cancer cell viability showed that all the tested complexes had low cytotoxic effect on murine colon carcinoma cell lines, but several times higher cytotoxicity on normal human colon carcinoma cells. (C) 2016 Elsevier B.V. All rights reserved.", publisher = "Elsevier", journal = "Journal of Molecular Structure", title = "Cytotoxicity of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-ethyl derivative of thiosalicylic acid", volume = "1116", pages = "264-271", doi = "10.1016/j.molstruc.2016.03.058" }
Nikolić, M. V., Mijajlović, M. Ž., Jevtić, V. V., Ratković, Z. R., Novaković, S. B., Bogdanović, G. A., Milovanović, J., Arsenijević, A., Stojanović, B., Trifunović, S. R.,& Radić, G. P.. (2016). Cytotoxicity of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-ethyl derivative of thiosalicylic acid. in Journal of Molecular Structure Elsevier., 1116, 264-271. https://doi.org/10.1016/j.molstruc.2016.03.058
Nikolić MV, Mijajlović MŽ, Jevtić VV, Ratković ZR, Novaković SB, Bogdanović GA, Milovanović J, Arsenijević A, Stojanović B, Trifunović SR, Radić GP. Cytotoxicity of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-ethyl derivative of thiosalicylic acid. in Journal of Molecular Structure. 2016;1116:264-271. doi:10.1016/j.molstruc.2016.03.058 .
Nikolić, Miloš V., Mijajlović, Marina Ž., Jevtić, Verica V., Ratković, Zoran R., Novaković, Slađana B., Bogdanović, Goran A., Milovanović, Jelena, Arsenijević, Aleksandar, Stojanović, Bojana, Trifunović, Srećko R., Radić, Gordana P., "Cytotoxicity of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-ethyl derivative of thiosalicylic acid" in Journal of Molecular Structure, 1116 (2016):264-271, https://doi.org/10.1016/j.molstruc.2016.03.058 . .