Synthesis, characterisation and antimicrobial activity of bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine and its complexes with Co-III, Ni-II, Cu-II and Zn-II
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Hollo, BertaMagyari, Jozsef
Ivkovic-Radovanovic, Vukosava
Vučković, Gordana
Tomić, Zoran D.
Szilagyi, Imre Miklos
Pokol, Gyorgy
Szecsenyi, Katalin Meszaros
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Four new complex compounds of bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine (Hz(2)DAP) ligand with Ni-II, Co-III, Cu-II and Zn-II metal centres were synthesised and characterised by single-crystal X-ray diffraction and IR spectral data. The antimicrobial activity of Hz(2)DAP and the obtained complexes [Co(Hz(2)DAP-H)Cl-2]center dot MeOH, [Ni(Hz(2)DAP-H)]Cl center dot MeOH, [Cu(Hz(2)DAP-H)Cl] and [Zn(Hz(2)DAP-2H)]center dot H2O were tested in vitro against selected Gram(-) and Gram(+) bacterial strains and fungi. The antimicrobial activity of the ligand is negligible, while its complexes with Ni-II, Co-III and Cu-II show considerable activity against Escherichia coli, Staphylococcus aureus and Micrococcus lysodeikticus. On the contrary, [Zn(Hz(2)DAP-2H)]center dot H2O promotes the growth of Candida albicans, while its antibacterial activity is negligible. On the basis of thermal data and those from coupled TG/MS measurements the decomposition mechanisms were determined and evaluated.... (C) 2014 Elsevier Ltd. All rights reserved.
Keywords:
Bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine / Ni-II, Co-III, Cu-II and Zn-II complexes / Antimicrobial activity / TG/MSSource:
Polyhedron, 2014, 80, SI, 142-150Funding / projects:
- Design, synthesis, characterization and assessment of practical applications of coordination and organometallic compounds (RS-MESTD-Basic Research (BR or ON)-172014)
- Secretariat for Science and Technological Development (Autonomous Province of Vojvodina, Republic of Serbia), Domus Hungarica, Hungarian Academy of Sciences [OTKA-PD-109129]
DOI: 10.1016/j.poly.2014.03.007
ISSN: 0277-5387
WoS: 000341348300019
Scopus: 2-s2.0-84905503967
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VinčaTY - JOUR AU - Hollo, Berta AU - Magyari, Jozsef AU - Ivkovic-Radovanovic, Vukosava AU - Vučković, Gordana AU - Tomić, Zoran D. AU - Szilagyi, Imre Miklos AU - Pokol, Gyorgy AU - Szecsenyi, Katalin Meszaros PY - 2014 UR - https://vinar.vin.bg.ac.rs/handle/123456789/100 AB - Four new complex compounds of bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine (Hz(2)DAP) ligand with Ni-II, Co-III, Cu-II and Zn-II metal centres were synthesised and characterised by single-crystal X-ray diffraction and IR spectral data. The antimicrobial activity of Hz(2)DAP and the obtained complexes [Co(Hz(2)DAP-H)Cl-2]center dot MeOH, [Ni(Hz(2)DAP-H)]Cl center dot MeOH, [Cu(Hz(2)DAP-H)Cl] and [Zn(Hz(2)DAP-2H)]center dot H2O were tested in vitro against selected Gram(-) and Gram(+) bacterial strains and fungi. The antimicrobial activity of the ligand is negligible, while its complexes with Ni-II, Co-III and Cu-II show considerable activity against Escherichia coli, Staphylococcus aureus and Micrococcus lysodeikticus. On the contrary, [Zn(Hz(2)DAP-2H)]center dot H2O promotes the growth of Candida albicans, while its antibacterial activity is negligible. On the basis of thermal data and those from coupled TG/MS measurements the decomposition mechanisms were determined and evaluated. (C) 2014 Elsevier Ltd. All rights reserved. T2 - Polyhedron T1 - Synthesis, characterisation and antimicrobial activity of bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine and its complexes with Co-III, Ni-II, Cu-II and Zn-II VL - 80 IS - SI SP - 142 EP - 150 DO - 10.1016/j.poly.2014.03.007 ER -
@article{ author = "Hollo, Berta and Magyari, Jozsef and Ivkovic-Radovanovic, Vukosava and Vučković, Gordana and Tomić, Zoran D. and Szilagyi, Imre Miklos and Pokol, Gyorgy and Szecsenyi, Katalin Meszaros", year = "2014", abstract = "Four new complex compounds of bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine (Hz(2)DAP) ligand with Ni-II, Co-III, Cu-II and Zn-II metal centres were synthesised and characterised by single-crystal X-ray diffraction and IR spectral data. The antimicrobial activity of Hz(2)DAP and the obtained complexes [Co(Hz(2)DAP-H)Cl-2]center dot MeOH, [Ni(Hz(2)DAP-H)]Cl center dot MeOH, [Cu(Hz(2)DAP-H)Cl] and [Zn(Hz(2)DAP-2H)]center dot H2O were tested in vitro against selected Gram(-) and Gram(+) bacterial strains and fungi. The antimicrobial activity of the ligand is negligible, while its complexes with Ni-II, Co-III and Cu-II show considerable activity against Escherichia coli, Staphylococcus aureus and Micrococcus lysodeikticus. On the contrary, [Zn(Hz(2)DAP-2H)]center dot H2O promotes the growth of Candida albicans, while its antibacterial activity is negligible. On the basis of thermal data and those from coupled TG/MS measurements the decomposition mechanisms were determined and evaluated. (C) 2014 Elsevier Ltd. All rights reserved.", journal = "Polyhedron", title = "Synthesis, characterisation and antimicrobial activity of bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine and its complexes with Co-III, Ni-II, Cu-II and Zn-II", volume = "80", number = "SI", pages = "142-150", doi = "10.1016/j.poly.2014.03.007" }
Hollo, B., Magyari, J., Ivkovic-Radovanovic, V., Vučković, G., Tomić, Z. D., Szilagyi, I. M., Pokol, G.,& Szecsenyi, K. M.. (2014). Synthesis, characterisation and antimicrobial activity of bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine and its complexes with Co-III, Ni-II, Cu-II and Zn-II. in Polyhedron, 80(SI), 142-150. https://doi.org/10.1016/j.poly.2014.03.007
Hollo B, Magyari J, Ivkovic-Radovanovic V, Vučković G, Tomić ZD, Szilagyi IM, Pokol G, Szecsenyi KM. Synthesis, characterisation and antimicrobial activity of bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine and its complexes with Co-III, Ni-II, Cu-II and Zn-II. in Polyhedron. 2014;80(SI):142-150. doi:10.1016/j.poly.2014.03.007 .
Hollo, Berta, Magyari, Jozsef, Ivkovic-Radovanovic, Vukosava, Vučković, Gordana, Tomić, Zoran D., Szilagyi, Imre Miklos, Pokol, Gyorgy, Szecsenyi, Katalin Meszaros, "Synthesis, characterisation and antimicrobial activity of bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine and its complexes with Co-III, Ni-II, Cu-II and Zn-II" in Polyhedron, 80, no. SI (2014):142-150, https://doi.org/10.1016/j.poly.2014.03.007 . .