Protective Role of Diabetes Mellitus on Abdominal Aortic Aneurysm Pathogenesis: Myth or Reality?
Abstract
An inverse association between diabetes mellitus (DM) and abdominal aortic aneurysm (AAA) risk have been reported. Apart from a lower AAA prevalence among patients with vs without DM, there are data showing that DM may exert a protective role on aneurysmal growth in patients with small AAAs, thus decreasing the risk of rupture. As atherosclerosis has almost the same risk factors as aneurysms, the decreased AAA prevalence in patients with DM may indicate that atherosclerosis is an associated feature and not a cause of the aneurysms. Alternatively, DM may be associated with factors that influence AAA formation. In this narrative review, we discuss the inverse association between DM and AAA. We also comment on underlying cellular and genetic pathophysiological mechanisms of DM, AAA and atherosclerosis. The effects of drugs, commonly prescribed in DM patients, on AAA development and growth are also considered.
Keywords:
Diabetes mellitus / abdominal aortic aneurysm / atherosclerosis / risk factorsSource:
Current Vascular Pharmacology, 2016, 14, 2, 196-200Funding / projects:
- Carotid disease in Serbia - pathologic dynamics, prevention, diagnostics and inovative therapeutic methods (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41002)
- Hormonal regulation of expression and activity of the nitric oxide synthase and sodium-potassium pump in experimental models of insulin resistance, diabetes and cardiovascular disorders (RS-MESTD-Basic Research (BR or ON)-173033)
DOI: 10.2174/1570161113666150529125127
ISSN: 1570-1611; 1875-6212
PubMed: 26022380
WoS: 000373712200010
Scopus: 2-s2.0-84958963778
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VinčaTY - JOUR AU - Radak, Đorđe J. AU - Tanasković, Slobodan AU - Katsiki, Niki AU - Isenović, Esma R. PY - 2016 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1005 AB - An inverse association between diabetes mellitus (DM) and abdominal aortic aneurysm (AAA) risk have been reported. Apart from a lower AAA prevalence among patients with vs without DM, there are data showing that DM may exert a protective role on aneurysmal growth in patients with small AAAs, thus decreasing the risk of rupture. As atherosclerosis has almost the same risk factors as aneurysms, the decreased AAA prevalence in patients with DM may indicate that atherosclerosis is an associated feature and not a cause of the aneurysms. Alternatively, DM may be associated with factors that influence AAA formation. In this narrative review, we discuss the inverse association between DM and AAA. We also comment on underlying cellular and genetic pathophysiological mechanisms of DM, AAA and atherosclerosis. The effects of drugs, commonly prescribed in DM patients, on AAA development and growth are also considered. T2 - Current Vascular Pharmacology T1 - Protective Role of Diabetes Mellitus on Abdominal Aortic Aneurysm Pathogenesis: Myth or Reality? VL - 14 IS - 2 SP - 196 EP - 200 DO - 10.2174/1570161113666150529125127 ER -
@article{ author = "Radak, Đorđe J. and Tanasković, Slobodan and Katsiki, Niki and Isenović, Esma R.", year = "2016", abstract = "An inverse association between diabetes mellitus (DM) and abdominal aortic aneurysm (AAA) risk have been reported. Apart from a lower AAA prevalence among patients with vs without DM, there are data showing that DM may exert a protective role on aneurysmal growth in patients with small AAAs, thus decreasing the risk of rupture. As atherosclerosis has almost the same risk factors as aneurysms, the decreased AAA prevalence in patients with DM may indicate that atherosclerosis is an associated feature and not a cause of the aneurysms. Alternatively, DM may be associated with factors that influence AAA formation. In this narrative review, we discuss the inverse association between DM and AAA. We also comment on underlying cellular and genetic pathophysiological mechanisms of DM, AAA and atherosclerosis. The effects of drugs, commonly prescribed in DM patients, on AAA development and growth are also considered.", journal = "Current Vascular Pharmacology", title = "Protective Role of Diabetes Mellitus on Abdominal Aortic Aneurysm Pathogenesis: Myth or Reality?", volume = "14", number = "2", pages = "196-200", doi = "10.2174/1570161113666150529125127" }
Radak, Đ. J., Tanasković, S., Katsiki, N.,& Isenović, E. R.. (2016). Protective Role of Diabetes Mellitus on Abdominal Aortic Aneurysm Pathogenesis: Myth or Reality?. in Current Vascular Pharmacology, 14(2), 196-200. https://doi.org/10.2174/1570161113666150529125127
Radak ĐJ, Tanasković S, Katsiki N, Isenović ER. Protective Role of Diabetes Mellitus on Abdominal Aortic Aneurysm Pathogenesis: Myth or Reality?. in Current Vascular Pharmacology. 2016;14(2):196-200. doi:10.2174/1570161113666150529125127 .
Radak, Đorđe J., Tanasković, Slobodan, Katsiki, Niki, Isenović, Esma R., "Protective Role of Diabetes Mellitus on Abdominal Aortic Aneurysm Pathogenesis: Myth or Reality?" in Current Vascular Pharmacology, 14, no. 2 (2016):196-200, https://doi.org/10.2174/1570161113666150529125127 . .